Lacrisert (Hydroxypropyl Cellulose Ophthalmic) - Summary

LACRISERT SUMMARY

LACRISERT ^®
(HYDROXYPROPYL CELLULOSE OPHTHALMIC INSERT)
STERILE OPHTHALMIC INSERT

LACRISERT (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye.

LACRISERT is indicated in patients with moderate to severe dry eye syndromes, including keratoconjunctivitis sicca. LACRISERT is indicated especially in patients who remain symptomatic after an adequate trial of therapy with artificial tear solutions.

LACRISERT is also indicated for patients with:

Exposure keratitis

Decreased corneal sensitivity

Recurrent corneal erosions

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NEWS HIGHLIGHTS

Published Studies Related to Lacrisert (Hydroxypropyl Cellulose Ophthalmic)

Single instillation of hydroxypropylcellulose-doxorubicin as treatment for superficial bladder carcinoma. [1994]
A single instillation of hydroxypropylcellulose (HPC)-doxorubicin (20 mg/20 ml) was performed in 20 patients with superficial bladder carcinoma. The therapeutic effect was assessed by cystoscopy at 14-30 days after the instillation, and the residual tumor tissue was resected by transurethral resection (TUR) when possible...

Preparation and characterization of novel semi-interpenetrating polymer network hydrogel microspheres of chitosan and hydroxypropyl cellulose for controlled release of chlorothiazide. [2009.02]
Novel semi-interpenetrating polymer network (IPN) hydrogel microspheres of chitosan (CS) and hydroxypropyl cellulose (HPC) were prepared by emulsion-cross-linking method using glutaraldehyde (GA) as a cross-linker. Chlorothiazide (CT), a diuretic and anti-hypertensive drug with limited water solubility, was successfully encapsulated into IPN microspheres...

Synthesis of hydroxypropylcellulose-poly(acrylic acid) particles with semi-interpenetrating polymer network structure. [2008.10]
To develop a novel type of semi-IPN particles using biocompatible materials, hydroxypropylcellulose-poly(acrylic acid) (HPC-PAA) particles with semi-interpenetrating polymer network structure and a porosity-structural surface were prepared by direct polymerization of acrylic acid monomer in the reaction system comprised of HPC and AA monomer and N,N'-methylenebisacrylamide (MBAAm).

Temperature stability and bioadhesive properties of delta9-tetrahydrocannabinol incorporated hydroxypropylcellulose polymer matrix systems. [2006.01]
The purpose of this study was to determine and compare the bioadhesive profiles of hydroxypropylcellulose (HPC) polymer matrices as a function of delta9-tetrahydrocannabinol (THC) content. In addition, the effect of processing temperature on the stability of THC and its extent of degradation to cannabinol (CBN) was investigated...

Structural characterization of thin hydroxypropylcellulose films. X-ray reflectivity studies. [2004.03.02]
Thin solid films of hydroxypropylcellulose (HPC) have been investigated using synchrotron X-ray reflectivity.

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Clinical Trials Related to Lacrisert (Hydroxypropyl Cellulose Ophthalmic)

Clinical Evaluation of T.R.U.E. TEST® Fragrance Mix and Thimerosal Allergens:Bioequivalence of PVP Formulations [Recruiting]
We are conducting an open, prospective, multi-center study to evaluate the bioequivalence of polyvinylpyrrolidone formulations of T. R.U. E. TEST fragrance mix and thimerosal allergens. Bioequivalence will be determined in 40 adult subjects, 20 per allergen, with a clinical history of contact dermatitis and a positive patch test (current or previous) to the corresponding reference petrolatum allergen ("sensitives").

Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate [Completed]

Efficacy of Cantharidin in Molluscum Contagiosum [Recruiting]
The University of North Carolina Department of Dermatology is conducting a clinical trial to evaluate a drug called cantharidin in the treatment of molluscum contagiosum. Molluscum is a common dermatologic disorder caused by a poxvirus. Molluscum typically presents with many flesh-colored bumps on the skin. It goes away on its own, though can last several months to several years. Cantharidin is a topical medicine which is applied at the clinic visit. It is well tolerated by the majority of children.

Clinical Evaluation of T.R.U.E. TEST® : Safety and Efficacy [Recruiting]
We propose an open, prospective, multi-center Phase III study to evaluate the diagnostic performance and safety of seven new T. R.U. E. Test allergens: Gold sodium thiosulfate, Hydrocortisone-17-butyrate, Bacitracin, Parthenolide, Methyldibromoglutaronitrile, Disperse blue 106, and Bronopol. Allergen performance and safety will be evaluated in adult patients with suspected contact dermatitis, and in adult patients with a known or suspected sensitization to at least one of the seven allergens.

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