LAClotion™ (ammonium lactate) lotion specially formulates 12% lactic acid, neutralized with ammonium hydroxide, as ammonium lactate to provide a lotion pH of 4.5-5.5. LAClotion™ also contains light mineral oil, glyceryl stearate, PEG-100 stearate, propylene glycol, polyoxyl 40 stearate, glycerin, magnesium aluminum silicate, laureth-4, cetyl alcohol, methyl and propyl parabens, methylcellulose, and water.
LAClotion™ is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.
Published Studies Related to Laclotion (Ammonium Lactate Topical)
A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea. [2009.12]
Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children... The liquid soap was found to be effective in patients with AD, as use of this soap in patients with stable mild to moderate AD improved the parameters studied.
A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. [2003.01]
Xerotic skin is a pattern of reaction to a variety of disorders (eg, winter xerosis, hereditary ichthyosis) with abnormalities of desquamation in common. The trial described in this article was a double-blind randomized-comparison clinical trial investigating the effect of pure lanolin versus ammonium lactate 12% cream in treating moderate to severe foot xerosis...
Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. 
BACKGROUND: Urea and ammonium lactate are used for the treatment of xerosis, with different degrees of success. This study compares the clinical effectiveness of these two agents... DISCUSSION: At day 14 of treatment, 40% urea cream was superior to 12% ammonium lactate for most of the instrumental and clinical assessments.
Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study. [1998.07]
Xerosis is defined as dehydration of skin characterized by redness, dry scaling, and fine crackling that may resemble the crackling of porcelain. The present double-blind trial was a randomized paired comparison study evaluating the keratolytic effect of 5% salicylic acid and 10% urea ointment (Kerasal) on one foot and 12% ammonium lactate lotion (Lac-Hydrin) on the other foot in mild-to-moderate xerosis...
Salicylic Acid 6% in an ammonium lactate emollient foam vehicle in the treatment of mild-to-moderate scalp psoriasis. [2011.03]
Scalp psoriasis is a common life-altering skin condition causing a great deal of distress.Salicylic acid 6% emollient foam provides a useful option in the treatment of psoriasis that is highly effective, well tolerated and acceptable to patients.
Clinical Trials Related to Laclotion (Ammonium Lactate Topical)
Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats [Completed]
Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic
lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic
stability in post-coronary artery bypass grafting(CABG) patients. Patients who were eligible
received either hypertonic lactate solution or Ringer's Lactate post-CABG in the ICU when
fluid resuscitation was needed.
Peritoneal/ Serum Lactate Ratio in Relaparotomy [Recruiting]
Laparotomy performed for both emergency of elective surgery may by complicated by
intrabdominal collection, anastomotic leakage, infarction and others. This conditions are
able to induce peritoneal inflammation. Inflamed peritoneum are able to produce excess of
lactate that we can measure by collecting fluid from peritoneal drainage.
Drainage were left in abdomen for monitoring intrabdominal condition until the passage of
stool or flatus. Minimum drainage of serum is present daily also in uncomplicated post
Serum lactate relates with increased systemic anaerobic metabolism such as SIRS, sepsis and
systemic hypoperfusion and it is easy to measure with a blood gas analysis.
We hypothesized that the increases of peritoneal/ serum lactate ratio could be an earlier,
sensible, non-invasive, and economical marker of post surgical complications. The decision
whether and when to perform a relaparotomy in secondary peritonitis is largely subjective
and based on professional experience. Actually no existing scoring system aids in this
The aim of this study is to demonstrate that this ratio could be and useful tool for the
surgeon in this decisional process.
Effect of Metformin on Lactate Metabolism [Completed]
The main objective of this study is to evaluate the influence of metformin on lactate
The main outcome is the lactate production following an exogenous lactate overload in healthy
male subjects without metformin and one week later with metformin.
The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients [Completed]
Previous clinical trials with 11. 2% Hypertonic Ringer's Lactate in post-operative CABG
subjects have shown an increase in several cardiac performance parameters, with lesser volume
of resuscitation fluid required to reach circulation volume, as compared to Sodium
Chloride. It also does not cause hyperchloremic acidosis, which is of value in treating shock
The primary objectives of this prospective, randomized, open-label trial are to evaluate the
clinical efficacy of hypertonic lactate in comparison to Ringer's lactate to maintain
hemodynamic stability in intra- and post-CABG subjects in relation to hemodynamic status and
body fluid balance, as well as to assess its safety in terms of lab parameters and occurrence
of adverse events. The secondary objectives are to evaluate comparative clinical efficacy of
the two fluids in relation to reduction in concomitant drug utilization, duration of
ventilator usage, length of stay in ICU as well as total duration of hospitalization and
neurocognitive status upto a period of 1 year post-CABG.
Safety of D-lactate Producing Probiotics [Recruiting]
In this study the investigators want to test the safety of D-lactate producing probiotics in
babies from birth to 1 month of age. Previous data demonstrated no increase in urinary
D-lactate in 4 month old infants supplemented with D-lactate producing probiotics. The
primary purpose of this study is to evaluate the influence of D-lactate producing probiotics
on D-lactate excretion in young infants during the neonatal period (days 0 - 28).