NEWS HIGHLIGHTS
Published Studies Related to Lac-Hydrin (Ammonium Lactate Topical)
A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea. [2009.12]
Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children... The liquid soap was found to be effective in patients with AD, as use of this soap in patients with stable mild to moderate AD improved the parameters studied.
An evaluation of the moisturizing and anti-itch effects of a lactic acid and pramoxine hydrochloride cream. [2004.02]
An open-label, single-center, observer-blinded, controlled trial was conducted during the winter months to evaluate the moisturizing and antipruritic effects of a unique formulation of lactic acid 12% neutralized with ammonium hydroxide and pramoxine hydrochloride (HCl) 1% in 24 women with a history of dry itchy skin...
A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. [2003.01]
Xerotic skin is a pattern of reaction to a variety of disorders (eg, winter xerosis, hereditary ichthyosis) with abnormalities of desquamation in common. The trial described in this article was a double-blind randomized-comparison clinical trial investigating the effect of pure lanolin versus ammonium lactate 12% cream in treating moderate to severe foot xerosis...
A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis. [2002.03]
Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis...
Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. [2002]
BACKGROUND: Urea and ammonium lactate are used for the treatment of xerosis, with different degrees of success. This study compares the clinical effectiveness of these two agents... DISCUSSION: At day 14 of treatment, 40% urea cream was superior to 12% ammonium lactate for most of the instrumental and clinical assessments.
Clinical Trials Related to Lac-Hydrin (Ammonium Lactate Topical)
Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit [Not yet recruiting]
The main objective of this study is to examine the agreement between arterial, central
venous, and peripheral venous lactate values in a population of medical Intensive Care Unit
(ICU) patients.
Peritoneal/ Serum Lactate Ratio in Relaparotomy [Recruiting]
Laparotomy performed for both emergency of elective surgery may by complicated by
intrabdominal collection, anastomotic leakage, infarction and others. This conditions are
able to induce peritoneal inflammation. Inflamed peritoneum are able to produce excess of
lactate that we can measure by collecting fluid from peritoneal drainage.
Drainage were left in abdomen for monitoring intrabdominal condition until the passage of
stool or flatus. Minimum drainage of serum is present daily also in uncomplicated post
operative period.
Serum lactate relates with increased systemic anaerobic metabolism such as SIRS, sepsis and
systemic hypoperfusion and it is easy to measure with a blood gas analysis.
We hypothesized that the increases of peritoneal/ serum lactate ratio could be an earlier,
sensible, non-invasive, and economical marker of post surgical complications. The decision
whether and when to perform a relaparotomy in secondary peritonitis is largely subjective
and based on professional experience. Actually no existing scoring system aids in this
decision.
The aim of this study is to demonstrate that this ratio could be and useful tool for the
surgeon in this decisional process.
Lactate Therapy After Traumatic Brain Injury [Recruiting]
Background: Although glucose is essential to cerebral function, abundant experimental and
clinical evidence demonstrates that endogenously released lactate, rather than glucose, is
the preferential energy substrate for the brain in conditions of stress and acute injury. In
severe Traumatic Brain Injury (TBI) patients monitored with cerebral microdialysis and brain
tissue oxygen (PbtO2), our preliminary data show that increased brain extracellular lactate
is frequently observed. Our findings indicate that elevated brain lactate more often occurs
in the absence of brain hypoxia/ischemia and is mainly the consequence of increased cerebral
glycolysis, i. e. it occurs in association with high extracellular pyruvate. These data
suggest that the primary source of elevated lactate is activated glycolysis and strongly
support the concept that endogenously released lactate can be utilized by the injured human
brain as energy substrate. They prompt further investigation to examine whether exogenous
lactate supplementation can be a valuable neuroprotective strategy after TBI. Indeed, in
animal models of brain injury, administration of exogenous lactate improves neuronal and
cognitive recovery.
Hypothesis: The investigators test the hypothesis that lactate therapy, administered during
the acute phase of TBI, might exercise neuroprotective actions by restoring brain energetics
and improving brain tissue PO2 and cerebral blood flow (CBF).
Aim of the study: The aim of this single-center study is to examine the effect of sodium
lactate infusion on cerebral extracellular metabolites, brain tissue PO2 and cerebral blood
flow, measured with CT perfusion.
Design: Prospective phase II interventional study examining the effect of a continuous 3-6
hours infusion of sodium lactate (20-40 µmol/kg/min), administered within 48 hours from TBI,
on cerebral extracellular glucose, pyruvate, glutamate, glycerol, PbtO2 and CBF. A total of
35 patients will be required to complete the study.
Trial Of Normal Saline Versus Ringer's Lactate In Paediatric Trauma Patients [Not yet recruiting]
Background: Trauma is a major cause of death in children and teenagers. When young patients
have suffered major traumatic injuries, they require intravenous (iv) fluids to keep their
blood vessels full and ensure blood flow to vital organs. Current fluid guidelines by
International Trauma Committees recommend either Normal Saline (NS) or Ringer's Lactate (RL)
as the fluid of choice for these patients. Although these solutions share some similarities
in their composition, there are also some significant differences in sodium, chloride and
lactate concentrations. Despite these differences in fluid composition, there has never been
a study comparing these two fluids in paediatric trauma patients to determine which is
optimal. In this study, the investigators aim to determine the optimal fluid choice for
trauma resuscitation of young patients.
Hypothesis: The investigators hypothesize that severely injured paediatric trauma patients
resuscitated with NS will have optimal blood sodium levels compared to patients resuscitated
with RL.
Methods: The investigators will study 50 paediatric trauma patients that will be randomized
so that half will randomly receive NS and half will receive RL as their only iv fluid for 24
hours. After 24 hours, the investigators will compare in blood the sodium level, the amount
of acid, and the concentrations of inflammation molecules in relation to those whom received
NS versus RL.
Expected Results and Significance: Maintaining optimal levels of these biochemical markers
is imperative in reducing morbidity and mortality in severely injured paediatric patients.
If significant differences are present, the investigators will be able to determine which
fluid is preferred and expect these data to complement current trauma resuscitation
guidelines.
Evaluation of Local Capillary Blood Lactate in Chronic Critical Ischemia of Lower Limb Before and After Revascularization [Not yet recruiting]
Evaluation of a new biological criterion, the local capillary blood lactates to optimize the
management of patients with chronic critical ischemia requiring revascularization fast.
Potential use in terms of capillary blood lactate as a diagnostic indicator of recurrent
ischemia in a limb revascularized.
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