LAC-HYDRIN SUMMARY
Lac-Hydrin® (ammonium lactate) Lotion 12%
Lac-Hydrin specially formulates 12% lactic acid, neutralized with ammonium hydroxide, as ammonium lactate to provide a lotion pH of 4.4-5.5.
Lac-Hydrin Cream is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.
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NEWS HIGHLIGHTS
Published Studies Related to Lac-Hydrin (Ammonium Lactate Topical)
An evaluation of the moisturizing and anti-itch effects of a lactic acid and pramoxine hydrochloride cream. [2004.02]
An open-label, single-center, observer-blinded, controlled trial was conducted during the winter months to evaluate the moisturizing and antipruritic effects of a unique formulation of lactic acid 12% neutralized with ammonium hydroxide and pramoxine hydrochloride (HCl) 1% in 24 women with a history of dry itchy skin...
A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. [2003.01]
Xerotic skin is a pattern of reaction to a variety of disorders (eg, winter xerosis, hereditary ichthyosis) with abnormalities of desquamation in common. The trial described in this article was a double-blind randomized-comparison clinical trial investigating the effect of pure lanolin versus ammonium lactate 12% cream in treating moderate to severe foot xerosis...
A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis. [2002.03]
Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis...
Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. [2002]
BACKGROUND: Urea and ammonium lactate are used for the treatment of xerosis, with different degrees of success. This study compares the clinical effectiveness of these two agents... DISCUSSION: At day 14 of treatment, 40% urea cream was superior to 12% ammonium lactate for most of the instrumental and clinical assessments.
Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study. [1999.10]
Two emollients, ammonium lactate 12% lotion and a liposome-based moisturizing lotion, were compared in a double-blind test for efficacy in the treatment of plantar xerosis. A total of 43 out of 57 participants (75%) with bilateral plantar xerosis followed instructions completely and applied the lotions (one to each foot) twice daily for 4 weeks...
Clinical Trials Related to Lac-Hydrin (Ammonium Lactate Topical)
Comparing the Efficacy of Ultravate Ointment in Combination With Lac-Hydrin Lotion in the Treatment of Psoriasis [Recruiting]
This is an investigator-masked, randomized, parallel, clinical study comparing the efficacy
of once daily versus twice daily application of Ultravate® ointment (halobetasol propionate
0. 05% ointment) in combination with Lac-Hydrin lotion (ammonium lactate topical) in the
treatment of stable plaque psoriasis. 1) Phase 1: Patients will be treated for two weeks
with combination therapy using Ultravate® ointment with Lac-Hydrin lotion and their
psoriasis plaques will be evaluated to test efficacy of the medication. Half the subjects
will be randomized to receive treatment with once a day Ultravate® ointment and twice daily
Lac-Hydrin lotion; the other half of subjects will receive twice daily Ultravate® ointment
with twice daily Lac-Hydrin lotion. Ultravate® ointment will be discontinued following two
weeks of treatment, in compliance with its FDA indication. Phase 2: The second treatment
phase will consist of a four-week observation period. Subjects will be re-randomized to
either continue using twice daily Lac-Hydrin lotion, versus no treatment. The purpose of
this second phase of the study is to investigate whether use of Lac-Hydrin monotherapy twice
daily can minimize risk of recurrence and maximize duration of therapeutic effect. Part of
this clinical study consists of the use of patient and physician satisfaction
questionnaires. These questionnaires will include questions about the satisfaction with the
formulation of each agent, questions about compliance with treatment, etc. Such questions
could be used to demonstrate patient and physician satisfaction with each agent, with
combination therapy, and to compare patient satisfaction rates among those randomized to
once daily versus twice daily application of Ultravate® ointment. The hypothesis is that
Ultravate ointment once daily in combination with Lac-Hydrin twice daily is equal in
efficacy to Ultravate ointment twice daily in combination with Lac-Hydrin twice daily.
Lactate Metabolism Study in HIV Infected Persons [Recruiting]
Lactic acidosis is a potentially life-threatening disease associated with the treatment of
chronic HIV infection. Although acidosis is rare, hyperlactatemia is common and may have long
term consequences yet to be recognized. Lactic acidosis is a manifestation of mitochondrial
toxicity; consequences which have yet to be fully recognized and understood. In this study,
we propose to look at lactate clearance and production by two methods, in four treatment
groups, including HIV positive subjects on highly active antiretroviral therapy (HAART)
treatment regimes and without HAART regimes, with liver steatosis and without, and compared
with HIV negative controls. Supplementation with cofactors thiamine, niacin and L-carnitine,
which may have a positive effect on lactate metabolism by facilitating mitochondrial
function, will be studied as well.
Lactic Acid Levels In Hypotensive Patients Without(Standard) and With Tourniquet [Not yet recruiting]
This study seeks to determine whether the Lactic Acid blood level in a critically ill patient
must be drawn with a non-tourniquet venipuncture. The null hypothesis is that there is no
significant difference in Lactic Acid blood level in critically ill patients in a sample
taken from either with a tourniquet or a non-tourniquet veni-puncture.
Monitoring of Lactic acid level is helpful in both identifying potentially serious ill
patients as well as identifying in the ICU patients with high morbidity and mortality.
When a patient arrives to an Emergency Department and that patient is hypotensive (BP less
than or equal to 90 systolic), the nursing staff often starts an IV and if possible draws the
patient's initial blood tests off that first IV site; or if the patient has had an IV started
in the field by EMS, the nursing staff will draw blood from another site using a tourniquet.
This initial work up by the nursing staff takes 15 - 20 minutes before a physician may see the
patient. Since the present standard Lactic Acid test must be drawn either by arterial
puncture or venipuncture without a tourniquet, this test is rarely done as part of their (the
RNs) initial blood draws.
This simple impediment of needing to repeat the venipuncture without a tourniquet, especially
in patients who often have venous access difficulty, delays the identification of appropriate
patients for early and aggressive management- particularly those with sepsis.
Our hypothesis is that this requirement for a non-tourniquet blood draw is unnecessary.
Preventive Sodium Lactate and Traumatic Brain Injury [Recruiting]
The goal of this study is to evaluate the effect of preventive intravenous infusion of half
molar sodium lactate on the onset of hypertensive intracranial episodes in severe head
trauma. The investigators hypothesize that preventive intravenous administration of sodium
lactate will decrease the number of treatments required to decrease intracranial pressure
during 48 hours.
EEG, Cerebral Oximetry, and Arterial to Jugular Venous Lactate to Assess Cerebral Ischemia During Carotid Endarterectomy [Recruiting]
A highly desired result during carotid endarterectomy (CEA) is the ability to predict and
warn the surgeon if the brain is at risk of damage during the period of time that the
carotid artery is cross-clamped for surgical repair of the vessel narrowing. A number of
approaches for cerebral monitoring have been developed, including EEG, cerebral oximetry,
and measurement of arterial to jugular venous concentration differences of oxygen, glucose
or lactate. This study will utilize and compare multiple monitoring approaches for detecting
when and if the brain is at risk of injury during CEA. As such, this robust approach to
monitoring may permit a more prompt intervention to prevent or limit damage should cerebral
ischemia occur. In this study we will compare a processed EEG monitor - - the EEGo, which
uses nonlinear analysis to a bispectral (BIS) index monitor, and to the FORE-SIGHT cerebral
oximeter to assess the ability of each to identify cerebral ischemia should it occur with
carotid artery cross-clamping during CEA. These monitors will be correlated with arterial to
jugular venous lactate concentration difference, which has recently been shown to be a
sensitive indicator of hemispheric ischemia during CEA.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, LAC-Hydrin has an overall score of 5. The effectiveness score is 6 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | LAC-Hydrin review by 31 year old male patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Moderately Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Extremely dry skin |
| Dosage & duration: | | 12% (dosage frequency: twice daily) for the period of 6 months |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | It was helpful in reducing the severity on my life-long extremely dry, flaky, itchy skin. It was recommended that I be certain to apply it directly after a shower, when the skin still retains some of it's moisture from the shower itself. This is true for all lotions, but seemed particularly helpful with the Lac-hydrin. Unfortunately, though it was more helpful than many lotions I've used, the benefits did not warrant the higher price of the product. Ultimately, I've found BETTER results with the much cheaper Eucerin and even Curel moisturizing lines. |
| Side effects: | | During the 6 months during which I used the Lac-hydrin, I didn't experience any negative side-effects. I was using it during winter months, so I don't have any feedback to offer on sun-sensitivity. I didn't experience any additional skin irritation that lessened my interest in the product. I simply moved on to other products because of the price. |
| Comments: | | The Lac-hydrin was applied topically to all parts of my body (expect my face) twice daily. My dermatologist recommended that one of the applications be directly after my shower. The skin will retain moisture from the shower for a bit, and the application of the Lac-hydrin will help to keep it there. I would reapply to dry skin again before bed. |
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Page last updated: 2008-08-10
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