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Kristalose (Lactulose) - Summary



KRISTALOSE® (LACTULOSE) is a synthetic disaccharide in the form of crystals for reconstitution prior to use for oral administration. Each 10 g of lactulose contains less than 0.3 g galactose and lactose as a total sum. The pH range is 3.0 to 7.0. Lactulose is a colonic acidifier which promotes laxation.

KRISTALOSE® (LACTULOSE) For Oral Solution is indicated for the treatment of constipation. In patients with a history of chronic constipation, lactulose therapy increases the number of bowel movements per day and the number of days on which bowel movements occur.

See all Kristalose indications & dosage >>


Media Articles Related to Kristalose (Lactulose)

Constipation: Foods to Eat, Foods to Avoid
Source: MedicineNet Constipation Specialty [2017.09.19]
Title: Constipation: Foods to Eat, Foods to Avoid
Category: MedicineNet Quiz
Created: 9/17/2015 1:55:00 PM
Last Editorial Review: 9/19/2017 7:26:06 PM

Source: MedicineNet Anal Fissure Specialty [2017.04.25]
Title: Constipation
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 4/25/2017 12:00:00 AM

Constipation (Home Remedies and Medications for Relief)
Source: MedicineNet Anal Fissure Specialty [2017.03.27]
Title: Constipation (Home Remedies and Medications for Relief)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 3/27/2017 12:00:00 AM

Laxatives (Constipation)
Source: MedicineNet Melanosis Coli Specialty [2016.11.10]
Title: Laxatives (Constipation)
Category: Diseases and Conditions
Created: 9/24/1999 12:00:00 AM
Last Editorial Review: 11/10/2016 12:00:00 AM

15 Foods That Cause Constipation
Source: MedicineNet Hypothyroidism During Pregnancy Specialty [2016.10.11]
Title: 15 Foods That Cause Constipation
Category: Diseases and Conditions
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 10/11/2016 12:00:00 AM

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Published Studies Related to Kristalose (Lactulose)

A randomised, double-blind study of polyethylene glycol 4000 and lactulose in the treatment of constipation in children. [2014]
treatment of chronic constipation in young children... CONCLUSIONS: PEG 4000 has superior efficacy to lactulose for the treatment of

A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy. [2011.08]
BACKGROUND: Minimal hepatic encephalopathy (MHE) impairs daily functioning and health-related quality of life (HRQoL). The modalities of treatment of MHE have not been adequately studied. AIMS: To compare lactulose, probiotics, and L-ornithine L-aspartate (LOLA) in treatment of MHE and effect on HRQoL by Sickness Impact Profile questionnaire... CONCLUSION: Lactulose, probiotics, and LOLA significantly improve MHE and HRQoL in patients with chronic liver disease.

Prophylaxis of hepatic encephalopathy in acute variceal bleed: a randomized controlled trial of lactulose versus no lactulose. [2011.06]
BACKGROUND AND AIMS: Acute variceal bleed (AVB) is an important precipitating factor for development of hepatic encephalopathy (HE). However, there is paucity of data on the role of lactulose for prevention of HE after AVB. We evaluated the role of lactulose for prophylaxis of HE after AVB... CONCLUSIONS: Lactulose is effective in prevention of HE in patients with cirrhosis and acute variceal bleed. (c) 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.

Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation? [2010.12]
BACKGROUND/AIMS: In the present study, we aimed to investigate if partially hydrolyzed guar gum (PHGG) can be used safely as a fiber source for treatment of constipation in children and to compare its success with the most commonly used osmotic laxative, lactulose... CONCLUSIONS: Treatment with partially hydrolyzed guar gum is as effective as lactulose treatment in relieving stool withholding and constipation-associated abdominal pain, and its use improves stool consistency. Lactulose seemed to have more side effects, including flatulence and sensation of bad taste.

Gastric emptying and orocaecal transit time of meals containing lactulose or inulin in men. [2010.08]
The H(2) breath test is ideal for orocaecal transit time (OCTT) measurement, as it is non-invasive and inexpensive. Indigestible substrates added to a test meal are metabolised by the colonic bacteria, resulting in the production of H(2) which is detected in end-exhalation breath...

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Clinical Trials Related to Kristalose (Lactulose)

A Preference Study Comparing Kristalose� and Liquid Lactulose [Completed]
This study will evaluate whether patients have an overall preference for Kristalose or liquid lactulose based on taste, consistency, and portability.

Elucidating the Influence of Lactulose Intake on the Gut Microbiota Composition [Recruiting]
This study will test the influence of lactulose of the human gut microbiota. Healthy volunteers will ingest 50g of lactulose and donate stool samples 1 day before as well as 1-2 days and 14 days after the test. Using sequencing and metabolomics techniques the investigators will identify changes in microbiota composition upon lactulose exposure.

Kristalose as Bowel Evacuant Prior to Colonoscopy [Completed]
To determine whether Kristalose causes a significant increase in hydrogen and/or methane gas levels in patients requiring bowel evacuation, and also to determine the safety, efficacy, and patient preference of Kristalose as a bowel evacuant

Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.) [Withdrawn]
The purpose of this study is to evaluate whether the use of polyethylene glycol is superior and more safe in treating hepatic encephalopathy compared to lactulose and also to determine if treatment with polyethylene glycol will reduce the duration of hospital stay.

Pilot Study of the Effect of Lactulose on Post Caesarean Section Constipation [Not yet recruiting]
Constipation following elective Caesarean sections (CS) is a common problem experienced by up to 50% of patients (1). The causes for this are multifactorial and include manipulation of the bowel during surgery, immobilisation and opiate based anaesthetic and analgesic techniques. To try to alleviate the problem of postoperative constipation, some anaesthetists prescribe postoperative lactulose in addition to postoperative analgesia, although no data exists that shows whether this has any beneficial effect on postoperative constipation. 1. Short term morbidity associated with Caesarean delivery. Hillan EM. Birth. 19 (4): 190-4).

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Page last updated: 2017-09-19

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