NEWS HIGHLIGHTS
Published Studies Related to Kionex (Sodium Polystyrene Sulfonate)
Efficacy of the cation exchange resin, sodium polystyrene sulfonate, to decrease iron absorption. [2000]
BACKGROUND: Iron is not bound by charcoal; therefore, a method of binding iron in the gastrointestinal tract to prevent absorption in iron overdose is needed...
Effect of three laxatives and a cation exchange resin on fecal sodium and potassium excretion. [1995.03]
BACKGROUND/AIMS: The treatment of hyperkalemia in patients with renal insufficiency often includes the ingestion of sorbitol and a cation exchange resin. Sorbitol alone may be used to remove sodium and water from overloaded patients. The efficacy of these regimens has never been compared with other laxative or laxative-resin combinations. The aim of the study was to compare the relative effect of three laxatives with different mechanisms of action, alone and in combination with resin, on fecal sodium and potassium excretion... CONCLUSIONS: In normal people, phenolphthalein (1) is preferable to other laxatives in causing fecal sodium and potassium excretion, (2) hastens resin transit through the intestine compared with other laxatives, and (3) produces greater fecal potassium excretion when combined with resin than phenolphthalein alone or other laxative-resin combinations.
Effect of sodium polystyrene sulfonate on lithium bioavailability. [1992.11]
STUDY OBJECTIVE: To examine the effect of a single dose of sodium polystyrene sulfonate and sorbitol on lithium absorption... CONCLUSION: Sodium polystyrene sulfonate and sorbitol may be used in patients immediately or shortly after ingestion of a significant acute overdose of lithium in situations in which hemodialysis cannot be instituted promptly.
Lithium absorption prevented by sodium polystyrene sulfonate in volunteers. [1992.11]
STUDY OBJECTIVE: To determine if sodium polystyrene sulfonate prevents absorption of lithium in human beings... CONCLUSION: Sodium polystyrene sulfonate administration decreased absorption of lithium after a lithium carbonate overdose. Sodium polystyrene sulfonate may be useful clinically for gastric decontamination after lithium overdoses.
[Digestive adverse effects due to sodium polystyrene sulfonate (Kayexalate) in dialysis patients] [2009.06]
Administered to reduce hyperkaliema in patients with chronic renal failure, sodium polystyrene sulfonate (Kayexalate) can cause digestive complications.In the present report, we evoke these complications and illustrate them with some pictures from personal observations.
Clinical Trials Related to Kionex (Sodium Polystyrene Sulfonate)
Study of AMG 785 in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing [Recruiting]
This is an international, multi-center, randomized, double blind, placebo controlled study
of AMG 785 in skeletally mature adults with a fresh unilateral tibial diaphyseal fracture
status post a definitive fracture fixation with an intramedullary (IM) nail. The primary
hypothesis for this study is that AMG 785 compared with placebo is effective in reducing
radiographic healing time of fresh tibial diaphyseal fractures.
Phase II Study of the Pathophysiology and Treatment With Enalapril and Polystyrene Sulfonate for Pseudohypoaldosteronism, Type I [Completed]
OBJECTIVES: I. Establish the sodium and potassium intake that will maintain a normovolemic
state in a patient with pseudohypoaldosteronism.
II. Determine the effect of extracellular fluid volume and serum potassium manipulations on
exercise tolerance, cardiac function, and endurance.
III. Investigate pharmacologic methods of limiting excretion of sodium in urine and sweat.
A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002 [Completed]
To evaluate the efficacy of AZT versus ddC in terms of survival, antiviral effects,
neurological status, and health status in patients post Pneumocystis carinii pneumonia (PCP)
who received long-term AZT therapy in ACTG protocol 002 While treatment with AZT has been
found to be effective in prolonging survival and reducing the numbers of opportunistic
infections in patients with AIDS, during the second year of administration of AZT an
acceleration in mortality has been observed. The reasons for this are not known at this time.
The study of what may be an AZT-resistant strain of HIV may benefit patients who have been
and are still receiving AZT or another drug used in treating HIV ddC. It is hoped that the
comparison of the effectiveness of AZT and ddC will benefit in the treatment of these
patients.
A Comparison of Topical Nepafenac to Placebo in Corneal Epithelial Healing Times and Postoperative Pain Relief of Patients Status-Post Photorefractive Keratectomy: A Double-Masked Randomized Prospective Study [Completed]
Nepafenac 0. 1% or placebo (Balanced Salt Solution, BSS), 1 drop three times daily in
contralateral eyes until healed.
To determine the comparable subjective pain level healing times of corneal epithelium (time
to epithelial closure) after photorefractive keratectomy (PRK), while using either the
commercial topical preparation of nepafenac (0. 1%) or placebo.
Progressive Splinting Status Post Elbow Fractures and Dislocations [Recruiting]
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