NEWS HIGHLIGHTS
Published Studies Related to Kionex (Sodium Polystyrene Sulfonate)
Efficacy of the cation exchange resin, sodium polystyrene sulfonate, to decrease iron absorption. [2000]
BACKGROUND: Iron is not bound by charcoal; therefore, a method of binding iron in the gastrointestinal tract to prevent absorption in iron overdose is needed...
Effect of three laxatives and a cation exchange resin on fecal sodium and potassium excretion. [1995.03]
BACKGROUND/AIMS: The treatment of hyperkalemia in patients with renal insufficiency often includes the ingestion of sorbitol and a cation exchange resin. Sorbitol alone may be used to remove sodium and water from overloaded patients. The efficacy of these regimens has never been compared with other laxative or laxative-resin combinations. The aim of the study was to compare the relative effect of three laxatives with different mechanisms of action, alone and in combination with resin, on fecal sodium and potassium excretion... CONCLUSIONS: In normal people, phenolphthalein (1) is preferable to other laxatives in causing fecal sodium and potassium excretion, (2) hastens resin transit through the intestine compared with other laxatives, and (3) produces greater fecal potassium excretion when combined with resin than phenolphthalein alone or other laxative-resin combinations.
Effect of sodium polystyrene sulfonate on lithium bioavailability. [1992.11]
STUDY OBJECTIVE: To examine the effect of a single dose of sodium polystyrene sulfonate and sorbitol on lithium absorption... CONCLUSION: Sodium polystyrene sulfonate and sorbitol may be used in patients immediately or shortly after ingestion of a significant acute overdose of lithium in situations in which hemodialysis cannot be instituted promptly.
Lithium absorption prevented by sodium polystyrene sulfonate in volunteers. [1992.11]
STUDY OBJECTIVE: To determine if sodium polystyrene sulfonate prevents absorption of lithium in human beings... CONCLUSION: Sodium polystyrene sulfonate administration decreased absorption of lithium after a lithium carbonate overdose. Sodium polystyrene sulfonate may be useful clinically for gastric decontamination after lithium overdoses.
Surface orientation of phenyl groups in poly(sodium 4-styrenesulfonate) and in poly(sodium 4-styrenesulfonate):poly(3,4-ethylenedioxythiophene) mixture examined by sum frequency generation vibrational spectroscopy. [2010.09.07]
Sum frequency generation (SFG) vibrational spectroscopy was used to investigate the surface phenyl ring orientations of spin-coated poly(sodium 4-styrenesulfonate) (PSSNa) and of PSSNa in the spin-coated polymer material Baytron P. Baytron P is a commercially available conducting polymer suspension with poly(3,4-ethylenedioxythiophene) (PEDOT) and PSSNa in water, which is widely used in organic electronic devices...
Clinical Trials Related to Kionex (Sodium Polystyrene Sulfonate)
Study of AMG 785 in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing [Recruiting]
This is an international, multi-center, randomized, double blind, placebo controlled study
of AMG 785 in skeletally mature adults with a fresh unilateral tibial diaphyseal fracture
status post a definitive fracture fixation with an intramedullary (IM) nail. The primary
hypothesis for this study is that AMG 785 compared with placebo is effective in reducing
radiographic healing time of fresh tibial diaphyseal fractures.
Biomechanical Assessment of Level Gait in Patient's Status Post Bladder Exstrophy [Recruiting]
The purpose of this study is to determine whether patients who have undergone exstrophy
closure may be at risk for long-term orthopedic issues manifest by gait abnormalities. This
study is a descriptive analysis of the study cohort's gait patterns and pelvic structure.
Specific Aim 1: to determine whether patients with classic bladder exstrophy who underwent
closure demonstrate gait abnormalities.
Hypothesis 1: Patients undergoing closure of bladder exstrophy (with or without pelvic
osteotomy) demonstrate gait abnormalities compared with a reference population.
Hypothesis 2: Patients undergoing closure of bladder exstrophy (with or without pelvic
osteotomy) will have below normal functional survey scores.
Manual Therapy and Exercise Versus Home Exercises in the Management of Patients Status Post Ankle Sprain [Recruiting]
A recent study has demonstrated that a physical therapist directed exercise program did not
result in greater reductions in disability and pain when compared to a home exercise
program. However, no manual therapy procedures were incorporated into the physical therapy
treatment program despite recent evidence suggesting that thrust and non-thrust manual
therapy techniques may be beneficial in reducing disability, pain and improving gait.
Therefore, the purpose of this study is to compare the effectiveness of a physical therapy
management approach consisting of manual therapy and exercise to a home program of exercise
only. The investigators hypothesize that the group receiving manual therapy and exercise
will have better outcomes.
Study To Assess Fracture Healing With Sclerostin Antibody [Recruiting]
This is an international, multi-center, randomized, double-blind, placebo-controlled study
to determine the efficacy, safety, and tolerability of AMG 785 in adults with a fresh
unilateral hip fracture, status post surgical fixation.
The primary hypothesis of this study is that AMG 785 compared with placebo is effective in
accelerating healing of hip fractures and improving physical functioning, as measured by the
TUG, for subjects with fresh unilateral low energy hip fractures, status post surgical
fixation.
Phase II Study of the Pathophysiology and Treatment With Enalapril and Polystyrene Sulfonate for Pseudohypoaldosteronism, Type I [Completed]
OBJECTIVES: I. Establish the sodium and potassium intake that will maintain a normovolemic
state in a patient with pseudohypoaldosteronism.
II. Determine the effect of extracellular fluid volume and serum potassium manipulations on
exercise tolerance, cardiac function, and endurance.
III. Investigate pharmacologic methods of limiting excretion of sodium in urine and sweat.
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