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Keppra XR (Levetiracetam) - Summary

 
 



KEPPRA XR SUMMARY

KEPPRA XR is an antiepileptic drug available as 500 mg and 750 mg (white) extended-release tablets for oral administration.

KEPPRA XR™ is indicated as adjunctive therapy in the treatment of partial onset seizures in patients ≥16 years of age with epilepsy.


See all Keppra XR indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Keppra XR (Levetiracetam)

Newer epilepsy drugs taken while pregnant not associated with lower IQs in children
Source: Epilepsy News From Medical News Today [2016.09.01]
Two epilepsy drugs, levetiracetam and topiramate, may not harm the thinking skills and IQs of school-age children born to women who took them while pregnant, according to a recent study.

Epilepsy in Elderly Could Signal Increased Stroke Risk
Source: Medscape NeurologyHeadlines [2017.03.17]
Elderly patients with seizures have an increased risk for future stroke, a new study shows, suggesting a seizure may 'signify hidden cerebrovascular disease,' researchers say.
Medscape Medical News

Updated epilepsy classification may lead to advances in diagnosis, treatment, and research
Source: Epilepsy News From Medical News Today [2017.03.10]
It has been nearly three decades since experts published a classification system related to epilepsy.

Modified Atkins diet helps children with rare form of epilepsy
Source: Epilepsy News From Medical News Today [2017.02.24]
Doose syndrome or myoclonic-astatic epilepsy is a rare syndrome accounting for one to two percent of childhood epilepsies.

Significant epilepsy gene discovery in dogs
Source: Epilepsy News From Medical News Today [2017.02.22]
Researh groups from the University of Helsinki, the LMU Munich and the University of Guelph have described in collaboration a novel myoclonic epilepsy in dogs and identified its genetic cause.

more news >>

Published Studies Related to Keppra XR (Levetiracetam)

Levetiracetam in the treatment of alcohol dependence: toward the end of the story? [2012]
that levetiracetam may be efficient in alcohol-related disorder... CONCLUSIONS: By conducting a state-of-the-art randomized-controlled clinical

A double-blind, placebo-controlled trial assessing the efficacy of levetiracetam extended-release in very heavy drinking alcohol-dependent patients. [2012]
population of very heavy drinkers... CONCLUSIONS: This multisite clinical trial showed no efficacy for levetiracetam

Double-masked, placebo-controlled study of intravenous levetiracetam for the treatment of status epilepticus and acute repetitive seizures in dogs. [2012]
BACKGROUND: Status epilepticus (SE) and acute repetitive seizures (ARS) are common canine neurologic emergencies...

A randomized, double-blind, placebo-controlled trial of levetiracetam for dyskinesia in Parkinson's disease. [2011.07]
BACKGROUND: This randomized double blind, placebo-controlled crossover study investigated the antidyskinetic effects of levetiracetam in Parkinson's disease... CONCLUSIONS: Levetiracetam was well tolerated at doses up to 2000 mg per day, but we did not detect any antidyskinetic properties. (c) 2011 Movement Disorder Society. Copyright (c) 2011 Movement Disorder Society.

The anticonvulsant levetiracetam for the treatment of pain in polyneuropathy: a randomized, placebo-controlled, cross-over trial. [2011.07]
Levetiracetam is an anticonvulsant which is assumed to act by modulating neurotransmitter release via binding to the vesicle protein SV2A. This could have an impact on signaling in the nociceptive system, and a pilot study indicated relief of neuropathic pain with levetiracetam. OBJECTIVES: The aim of this study was to test the analgesic effect of levetiracetam in painful polyneuropathy... CONCLUSION: This study indicates that the anticonvulsant levetiracetam has no clinically relevant effect on painful polyneuropathy. Copyright (c) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.

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Clinical Trials Related to Keppra XR (Levetiracetam)

Conversion to Monotherapy Study With Keppra XR for Partial Seizures [Completed]
The primary objective of this study is to assess the efficacy of two doses of Keppra XR compared with a historical control as the placebo, in the monotherapy treatment of partial onset seizures.

IV Keppra in the Emergency Department for Prevention of Early Recurrent Seizures [Completed]
This study is looking at three seizure medicines. Patients with seizures are usually treated with phenytoin (Dilantin) or Fosphenytoin. These medicines can be given intravenously (IV)or by mouth. Another seizure medicine, levetiracetam (Keppra) can now be given this way also. This study will compare IV phenytoin (Dilantin) and IV fosphenytoin to levetiracetam (Keppra) in patients who have had a recent seizure. Only patients with a history of seizures can be involved. The patient must present to the emergency department within 4 hours of a seizure. The purpose of this study is to compare these three drugs, phenytoin (Dilantin), fosphenytoin, and levetiracetam (Keppra). The investigators are looking to see if these drugs can prevent another seizure in the next 24 hours. We are also looking for any possible side effects.

Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures [Completed]
To provide continued treatment of Keppra XR (Levetiracetam XR) and to assess the long term safety of Keppra XR in subjects with partial onset seizures.

Keppra for Cervical Dystonia [Suspended]
The purpose of this study is to evaluate if there is an improved response in CD symptoms when Keppra is used as adjunctive therapy to Botox.

Efficacy and Safety of Levetiracetam in Prevention of Alcohol Relapse in Recently Detoxified Alcohol Dependent Patients [Completed]
Prospective randomized double blind controlled trial in prevention of relapse in recently detoxified alcohol dependent patients with levetiracetam and placebo.

more trials >>

Reports of Suspected Keppra XR (Levetiracetam) Side Effects

Convulsion (23)Foetal Exposure During Pregnancy (19)Pregnancy (16)Upper Respiratory Tract Infection (10)Premature Baby (10)Death (6)Dyspepsia (6)Inappropriate Schedule of Drug Administration (6)Rash (6)Cerebrovascular Accident (6)more >>


Page last updated: 2017-03-17

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