NOT FOR USE IN NEONATES CONTAINS BENZYL ALCOHOL
For Intra-articular or Intralesional Use Only
NOT FOR INTRAVENOUS, INTRAMUSCULAR, INTRAOCULAR, EPIDURAL, OR INTRATHECAL USE
DESCRIPTION
Kenalog®-10 Injection (triamcinolone
acetonide injectable suspension, USP) is triamcinolone acetonide, a synthetic
glucocorticoid corticosteroid with marked anti-inflammatory action, in a sterile
aqueous suspension suitable for intralesional and intra-articular injection.
THIS FORMULATION IS SUITABLE FOR INTRA-ARTICULAR AND INTRALESIONAL USE ONLY.
Each mL of the sterile aqueous suspension provides 10 mg triamcinolone
acetonide, with sodium chloride for isotonicity, 0.9% (w/v) benzyl alcohol
as a preservative, 0.75% carboxymethylcellulose sodium, and 0.04% polysorbate
80; sodium hydroxide or hydrochloric acid may have been added to adjust pH
between 5.0 and 7.5. At the time of manufacture, the air in the container
is replaced by nitrogen.
The chemical name for triamcinolone acetonide is 9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
cyclic 16,17-acetal with acetone. Its structural formula is:
MW 434.50
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CLINICAL PHARMACOLOGY
Glucocorticoids, naturally occurring and synthetic, are adrenocortical
steroids that are readily absorbed from the gastrointestinal tract.
Naturally occurring glucocorticoids (hydrocortisone and cortisone),
which also have salt-retaining properties, are used as replacement therapy
in adrenocortical deficiency states. Synthetic analogs such as triamcinolone
are primarily used for their anti-inflammatory effects in disorders of many
organ systems.
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