Kemstro (Baclofen) - Summary

KEMSTRO SUMMARY

KEMSTRO™ (baclofen orally disintegrating tablets)

KEMSTRO™ (baclofen orally disintegrating tablets) is a muscle relaxant and antispastic. Baclofen USP is a white to off-white, odorless or practically odorless crystalline powder. It is slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform. Its chemical name is 4-amino-3-(4-chlorophenyl)-butanoic acid.

KEMSTRO™ is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.

Patients should have reversible spasticity so that treatment with KEMSTRO™ will aid in restoring residual function.

KEMSTRO™ may also be of some value in patients with spinal cord injuries and other spinal cord diseases.

KEMSTRO™ is not indicated in the treatment of skeletal muscle spasm resulting from rheumatic disorders.

The efficacy of KEMSTRO™ in stroke, cerebral palsy, and Parkinson's disease has not been established and, therefore, it is not recommended for these conditions.

KEMSTRO NEWS HIGHLIGHTS

Media Articles Related to Kemstro (Baclofen)

Baclofen Aids Abstinence in Alcoholics With Cirrhosis
Source: MedicineNet baclofen Specialty [2007.12.10]

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Published Studies Related to Kemstro (Baclofen)

Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. [2007.12.08]

Dysfunctional voiding confirmed by transdermal perineal electromyography, and its effective treatment with baclofen in women with lower urinary tract symptoms: a randomized double-blind placebo-controlled crossover trial. [2007.09]

Intrathecal baclofen in children with spastic cerebral palsy: a double-blind, randomized, placebo-controlled, dose-finding study. [2007.09]

Suppression of LTP-like plasticity in human motor cortex by the GABAB receptor agonist baclofen. [2007.06]

Dysfunctional voiding confirmed by transdermal perineal electromyography, and its effective treatment with baclofen in women with lower urinary tract symptoms: a randomized double-blind placebo-controlled crossover trial. [2007.05.19]

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Clinical Trials Related to Kemstro (Baclofen)

A Multicenter, Open-Label Randomized Crossover Trial to Assess Subject Preference for Kemstro™ Compared to Conventional Baclofen Tablets in Subjects With Stable Multiple Sclerosis [Completed]

Comparative Bioavailability Study of Baclofen 20 mg Tablets in Healthy Male Volunteers / Fasting State [Completed]

Treating Alcohol Withdrawal With Oral Baclofen [Completed]

Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity [Not yet recruiting]

Efficacy of Baclofen in the Treatment of Alcohol Addiction [Completed]

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