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Keflex (Cephalexin) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Gastrointestinal — Onset of pseudomembranous colitis may occur during or after antibacterial treatment. (See WARNINGS.) Nausea and vomiting have been reported rarely. The most frequent side effect has been diarrhea. It was very rarely severe enough to warrant cessation of therapy. Dyspepsia, gastritis, and abdominal pain have also occurred. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely.

Hypersensitivity — Allergic reactions in the form of rash, urticaria, angioedema, and, rarely, erythema multiforme, Stevens-Johnson syndrome, or toxic epidermal necrolysis have been observed. These reactions usually subsided upon discontinuation of the drug. In some of these reactions, supportive therapy may be necessary. Anaphylaxis has also been reported.

Other reactions have included genital and anal pruritus, genital moniliasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis, and joint disorder. Reversible interstitial nephritis has been reported rarely. Eosinophilia, neutropenia, thrombocytopenia, hemolytic anemia, and slight elevations in AST and ALT have been reported.

In addition to the adverse reactions listed above that have been observed in patients treated with Keflex, the following adverse reactions and altered laboratory tests have been reported for cephalosporin class antibiotics:

  •   Adverse Reactions — Fever, colitis, aplastic anemia, hemorrhage, renal dysfunction, and toxic nephropathy.
  •   Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (see   INDICATIONS AND USAGE   and   PRECAUTIONS, General). If seizures associated with drug therapy should occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.
  •   Altered Laboratory Tests — Prolonged prothrombin time, increased BUN, increased creatinine, elevated alkaline phosphatase, elevated bilirubin, elevated LDH, pancytopenia, leukopenia, and agranulocytosis.


REPORTS OF SUSPECTED KEFLEX SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Keflex. The information is not vetted and should not be considered as verified clinical evidence.

Possible Keflex side effects / adverse reactions in 81 year old male

Reported by a pharmacist from United States on 2011-10-06

Patient: 81 year old male weighing 109.0 kg (239.8 pounds)

Reactions: Cellulitis, Chills, Pyrexia, Rash

Adverse event resulted in: hospitalization

Suspect drug(s):
Keflex

Other drugs received by patient: Glimepiride; Folic Acid; M.v.i.; Trilipix; Simvastatin; Coumadin; VIT E; Amlodipine; Lasix; Lopressor; Glyburide; Aspirin



Possible Keflex side effects / adverse reactions in 58 year old female

Reported by a pharmacist from United States on 2011-10-06

Patient: 58 year old female weighing 74.5 kg (163.9 pounds)

Reactions: Dyspnoea, Anaphylactic Reaction

Adverse event resulted in: hospitalization

Suspect drug(s):
Keflex
    Dosage: 250mg q6hr po recent
    Administration route: Oral
    Indication: Exophthalmos

Keflex
    Dosage: 250mg q6hr po recent
    Administration route: Oral
    Indication: Postoperative Care

Other drugs received by patient: Zocor; Lantus; Lorazepam; Levothyroxine Sodium; Wellbutrin XL; Lamictal; Humalog; Aspirin



Possible Keflex side effects / adverse reactions in 60 year old female

Reported by a consumer/non-health professional from United States on 2011-11-01

Patient: 60 year old female

Reactions: Drug Ineffective

Suspect drug(s):
Biaxin
    Indication: Product Used FOR Unknown Indication

Doxycycline

Keflex
    Indication: Product Used FOR Unknown Indication

Zithromax

Other drugs received by patient: Antidepressants; Allegra; Advair Diskus 100/50; Singulair



See index of all Keflex side effect reports >>

Drug label data at the top of this Page last updated: 2007-03-16

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