ADVERSE REACTIONS
Gastrointestinal — Onset of pseudomembranous colitis may occur during or after antibacterial treatment. (See WARNINGS.) Nausea and vomiting have been reported rarely. The most frequent side effect has been diarrhea. It was very rarely severe enough to warrant cessation of therapy. Dyspepsia, gastritis, and abdominal pain have also occurred. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely.
Hypersensitivity — Allergic reactions in the form of rash, urticaria, angioedema, and, rarely, erythema multiforme, Stevens-Johnson syndrome, or toxic epidermal necrolysis have been observed. These reactions usually subsided upon discontinuation of the drug. In some of these reactions, supportive therapy may be necessary. Anaphylaxis has also been reported.
Other reactions have included genital and anal pruritus, genital moniliasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis, and joint disorder. Reversible interstitial nephritis has been reported rarely. Eosinophilia, neutropenia, thrombocytopenia, hemolytic anemia, and slight elevations in AST and ALT have been reported.
In addition to the adverse reactions listed above that have been observed in patients treated with Keflex, the following adverse reactions and altered laboratory tests have been reported for cephalosporin class antibiotics:
Adverse Reactions — Fever, colitis, aplastic anemia, hemorrhage, renal dysfunction, and toxic nephropathy. Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (see
INDICATIONS AND USAGE and PRECAUTIONS, General). If seizures associated with drug therapy should occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.
Altered Laboratory Tests — Prolonged prothrombin time, increased BUN, increased creatinine, elevated alkaline phosphatase, elevated bilirubin, elevated LDH, pancytopenia, leukopenia, and agranulocytosis.
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REPORTS OF SUSPECTED KEFLEX SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Keflex. The information is not vetted and should not be considered as verified clinical evidence.
Possible Keflex side effects / adverse reactions in 81 year old male
Reported by a pharmacist from United States on 2011-10-06
Patient: 81 year old male weighing 109.0 kg (239.8 pounds)
Reactions: Cellulitis, Chills, Pyrexia, Rash
Adverse event resulted in: hospitalization
Suspect drug(s):
Keflex
Other drugs received by patient: Glimepiride; Folic Acid; M.v.i.; Trilipix; Simvastatin; Coumadin; VIT E; Amlodipine; Lasix; Lopressor; Glyburide; Aspirin
Possible Keflex side effects / adverse reactions in 58 year old female
Reported by a pharmacist from United States on 2011-10-06
Patient: 58 year old female weighing 74.5 kg (163.9 pounds)
Reactions: Dyspnoea, Anaphylactic Reaction
Adverse event resulted in: hospitalization
Suspect drug(s):
Keflex
Dosage: 250mg q6hr po recent
Administration route: Oral
Indication: Exophthalmos
Keflex
Dosage: 250mg q6hr po recent
Administration route: Oral
Indication: Postoperative Care
Other drugs received by patient: Zocor; Lantus; Lorazepam; Levothyroxine Sodium; Wellbutrin XL; Lamictal; Humalog; Aspirin
Possible Keflex side effects / adverse reactions in 60 year old female
Reported by a consumer/non-health professional from United States on 2011-11-01
Patient: 60 year old female
Reactions: Drug Ineffective
Suspect drug(s):
Biaxin
Indication: Product Used FOR Unknown Indication
Doxycycline
Keflex
Indication: Product Used FOR Unknown Indication
Zithromax
Other drugs received by patient: Antidepressants; Allegra; Advair Diskus 100/50; Singulair
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