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Kadian (Morphine Sulfate) - Summary

 
 



KADIAN SUMMARY

KADIAN® capsules 20, 30, 50, 60 and 100 mg contain identical polymer coated sustained release pellets of morphine sulfate for oral administration.

KADIAN® is indicated for the management of moderate to severe pain where treatment with an opioid analgesic is indicated for more than a few days (see CLINICAL PHARMACOLOGY; Clinical Studies).

KADIAN® was developed for use in patients with chronic pain who require repeated dosing with a potent opioid analgesic, and has been tested in patients with pain due to malignant conditions. KADIAN® has not been tested as an analgesic for the treatment of acute pain or in the postoperative setting and is not recommended for such use.


See all Kadian indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Kadian (Morphine)

For a Child's Fracture, Use Ibuprofen, Not Morphine: Study
Source: MedicineNet codeine Specialty [2014.10.28]
Title: For a Child's Fracture, Use Ibuprofen, Not Morphine: Study
Category: Health News
Created: 10/27/2014 12:00:00 AM
Last Editorial Review: 10/28/2014 12:00:00 AM

Ibuprofen 'preferable to morphine' for child fractures
Source: Pain / Anesthetics News From Medical News Today [2014.10.27]
Although ibuprofen and oral morphine are both effective at reducing pain among children with fractures, morphine is associated with more adverse effects, suggests new study.

Pain care and management for older Americans
Source: Caregivers / Homecare News From Medical News Today [2014.11.22]
The first issue of a new publication series from The Gerontological Society of America (GSA) called From Policy to Practice explores pain as a public health problem and takes a look at how various...

Abuse-Resistant Prescription Painkiller Approved
Source: MedicineNet Chronic Pain Specialty [2014.11.21]
Title: Abuse-Resistant Prescription Painkiller Approved
Category: Health News
Created: 11/20/2014 12:00:00 AM
Last Editorial Review: 11/21/2014 12:00:00 AM

MRI Can Be Painful, Disruptive for People With Cochlear Implants
Source: MedicineNet Deafness Specialty [2014.11.21]
Title: MRI Can Be Painful, Disruptive for People With Cochlear Implants
Category: Health News
Created: 11/20/2014 12:00:00 AM
Last Editorial Review: 11/21/2014 12:00:00 AM

more news >>

Published Studies Related to Kadian (Morphine)

Periarticular infiltration of 0.25% bupivacaine on top of femoral nerve block and intrathecal morphine improves quality of pain control after total knee arthroplasty: a randomized double-blind placebo controlled clinical trial. [2012]
CONCLUSION: Adding periarticular infiltration to femoral block and intrathecal

Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain. [2012]
Although often successful in acute settings, long-term use of opioid pain medications may be accompanied by waning levels of analgesic response not readily attributable to advancing underlying disease, necessitating dose escalation to attain pain relief... Improvements in pain and functional ability were observed.

Tolerability and efficacy of two synergistic ratios of oral morphine and oxycodone combinations versus morphine in patients with chronic noncancer pain. [2012]
SETTING: Clinical study centers in Australia... CONCLUSION: A 3:2 or 1:2 fixed ratio combination of morphine and oxycodone (MOX)

Long-acting morphine following hip or knee replacement: a randomized, double-blind and placebo-controlled trial. [2012]
routine postoperative regimen for total hip or knee replacement surgery... CONCLUSIONS: Thirty milligrams twice per day of long-acting morphine from days 1

The effect of intravenous morphine on the level of spinal anesthesia with lidocaine. [2012]
CONCLUSION: Although some studies had proved the efficacy of systemic use of

more studies >>

Clinical Trials Related to Kadian (Morphine)

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for treating moderate to severe chronic pain over a 12 week period.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

Study of Kadian NT in Subjects With Chronic Moderate to Severe Nonmalignant Pain [Active, not recruiting]

more trials >>

Reports of Suspected Kadian (Morphine) Side Effects

Toxicity TO Various Agents (43)Unresponsive TO Stimuli (40)Completed Suicide (14)Hypotension (14)Pulmonary Oedema (11)Accidental Death (10)Intentional Drug Misuse (10)Drug Abuse (8)Cardio-Respiratory Arrest (8)Brain Oedema (8)more >>


Page last updated: 2014-11-22

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