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Kadian (Morphine Sulfate) - Summary

 
 



KADIAN SUMMARY

KADIAN® capsules 20, 30, 50, 60 and 100 mg contain identical polymer coated sustained release pellets of morphine sulfate for oral administration.

KADIAN® is indicated for the management of moderate to severe pain where treatment with an opioid analgesic is indicated for more than a few days (see CLINICAL PHARMACOLOGY; Clinical Studies).

KADIAN® was developed for use in patients with chronic pain who require repeated dosing with a potent opioid analgesic, and has been tested in patients with pain due to malignant conditions. KADIAN® has not been tested as an analgesic for the treatment of acute pain or in the postoperative setting and is not recommended for such use.


See all Kadian indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Kadian (Morphine)

A decade-long effort in genetic engineering is close to re-programming yeast cells to make palliative medicines in stainless steel vats
Source: Pain / Anesthetics News From Medical News Today [2014.08.26]
For centuries poppy plants have been grown to provide opium, the compound from which morphine and other important medicines such as oxycodone are derived.

More resilient people tend to have a higher pain tolerance
Source: Anxiety / Stress News From Medical News Today [2014.09.13]
Resilience, a person's ability to overcome adverse circumstances, is the main quality associated with pain tolerance among patients and their adjustment to chronic pain.

Avoiding Pain Management Prosecutions
Source: Medscape NeurologyHeadlines [2014.09.12]
The key to staying out of court, says an attorney with years of experience in the field, is keeping up-to-date documentation.
Medscape Medical News

International Conference and Exhibition on Pain Medicine, June 08-10, 2015, Chicago
Source: Conferences News From Medical News Today [2014.09.12]
OMICS Group is pleased to invite you to participate in the International Conference and Exhibition on Pain Medicine during June 08-10, 2015 at Chicago, USA.

Groundbreaking study reveals best positions for sex for men who have back pain
Source: Sexual Health / STDs News From Medical News Today [2014.09.12]
Contrary to popular belief, spooning is not always the best sex position for those with a bad back, according to new research from the University of Waterloo.

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Published Studies Related to Kadian (Morphine)

Periarticular infiltration of 0.25% bupivacaine on top of femoral nerve block and intrathecal morphine improves quality of pain control after total knee arthroplasty: a randomized double-blind placebo controlled clinical trial. [2012]
CONCLUSION: Adding periarticular infiltration to femoral block and intrathecal

Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain. [2012]
Although often successful in acute settings, long-term use of opioid pain medications may be accompanied by waning levels of analgesic response not readily attributable to advancing underlying disease, necessitating dose escalation to attain pain relief... Improvements in pain and functional ability were observed.

Tolerability and efficacy of two synergistic ratios of oral morphine and oxycodone combinations versus morphine in patients with chronic noncancer pain. [2012]
SETTING: Clinical study centers in Australia... CONCLUSION: A 3:2 or 1:2 fixed ratio combination of morphine and oxycodone (MOX)

Long-acting morphine following hip or knee replacement: a randomized, double-blind and placebo-controlled trial. [2012]
routine postoperative regimen for total hip or knee replacement surgery... CONCLUSIONS: Thirty milligrams twice per day of long-acting morphine from days 1

The effect of intravenous morphine on the level of spinal anesthesia with lidocaine. [2012]
CONCLUSION: Although some studies had proved the efficacy of systemic use of

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Clinical Trials Related to Kadian (Morphine)

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for treating moderate to severe chronic pain over a 12 week period.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

Study of Kadian NT in Subjects With Chronic Moderate to Severe Nonmalignant Pain [Active, not recruiting]

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Reports of Suspected Kadian (Morphine) Side Effects

Toxicity TO Various Agents (43)Unresponsive TO Stimuli (40)Completed Suicide (14)Hypotension (14)Pulmonary Oedema (11)Accidental Death (10)Intentional Drug Misuse (10)Drug Abuse (8)Cardio-Respiratory Arrest (8)Brain Oedema (8)more >>


Page last updated: 2014-09-13

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