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Kadian (Morphine Sulfate) - Summary

 
 



BOXED WARNING

KADIAN ® contains morphine sulfate, an opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics. KADIAN ® can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing KADIAN ® in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse or diversion.

KADIAN ® capsules are an extended-release oral formulation of morphine sulfate indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.

KADIAN® Capsules are NOT for use as a prn analgesic.

KADIAN ® 100 mg and 200 mg Capsules ARE FOR USE IN OPIOID-TOLERANT PATIENTS ONLY.  Ingestion of these capsules or of the pellets within the capsules may cause fatal respiratory depression when administered to patients not already tolerant to high doses of opioids.  KADIAN ® CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED ON APPLE SAUCE.  THE PELLETS IN THE CAPSULES ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE OF MORPHINE.

 

KADIAN SUMMARY

KADIAN® (morphine sulfate) capsules are an opioid analgesic supplied in 10 mg, 20 mg, 30 mg, 50 mg, 60 mg, 80 mg, 100 mg, and 200 mg strengths for oral administration.

KADIAN® Capsules are an extended-release oral formulation of morphine sulfate indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time (see CLINICAL PHARMACOLOGY).

KADIAN ® Capsules are NOT intended for use as a prn analgesic.

KADIAN® is not indicated for pain in the immediate postoperative period (the first 12-24 hours following surgery), or if the pain is mild or not expected to persist for an extended period of time. KADIAN® is only indicated for postoperative use if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines.)


See all Kadian indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Kadian (Morphine)

Researchers discover how opium poppies synthesize morphine
Source: Pain / Anesthetics News From Medical News Today [2015.07.14]
Discovery could lead to the development of alternative painkillersMany people who live in developing countries do not have access to the pain relief that comes from morphine or other analgesics.

Lidocaine Eases Pain, Improves Sex in Breast Cancer Patients
Source: Medscape Hematology-Oncology Headlines [2015.07.31]
Topical lidocaine makes intercourse more comfortable in postmenopausal breast cancer patients with severe dyspareunia.
Medscape Medical News

Vaginal Pain
Source: MedicineNet Itch Specialty [2015.07.31]
Title: Vaginal Pain
Category: Diseases and Conditions
Created: 4/17/2009 12:00:00 AM
Last Editorial Review: 7/31/2015 12:00:00 AM

Health Tip: Easing Neck Pain at Night
Source: MedicineNet Neck Pain Specialty [2015.07.31]
Title: Health Tip: Easing Neck Pain at Night
Category: Health News
Created: 7/31/2015 12:00:00 AM
Last Editorial Review: 7/31/2015 12:00:00 AM

Knee Replacement May Ease Pain for Rheumatoid Arthritis Patients
Source: MedicineNet Osteoarthritis Specialty [2015.07.31]
Title: Knee Replacement May Ease Pain for Rheumatoid Arthritis Patients
Category: Health News
Created: 7/30/2015 12:00:00 AM
Last Editorial Review: 7/31/2015 12:00:00 AM

more news >>

Published Studies Related to Kadian (Morphine)

Evaluation of a single-dose, extended-release epidural morphine formulation for pain control after lumbar spine surgery. [2014]
DepoDur, an extended-release epidural morphine, has been used effectively for postoperative pain control following many orthopaedic and general surgery procedures and has provided prolonged analgesia when compared with Duramorph. The goal of this article was to compare the safety and analgesic efficacy of DepoDur versus Duramorph after lumbar spine surgery...

Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trial. [2014]
effects on platelets... CONCLUSIONS: Morphine delays clopidogrel absorption, decreases plasma levels of

The postoperative analgesic effect of morphine and paracetamol in the patients undergoing laparotomy, using PCA method. [2013]
CONCLUSION: Morphine seems to be more effective at 2 and 4 hours, but after 4

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

Effect of morphine on lower urinary tract discomfort after transurethral resection of prostate under general anesthesia: a randomised clinical study. [2013]
TURP-related LUT discomfort symptoms... CONCLUSION: Based on these results, we conclude that morphine effectively reduces

more studies >>

Clinical Trials Related to Kadian (Morphine)

Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain following third molar extraction.

A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for treating moderate to severe chronic pain over a 12 week period.

Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. After initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. The rescue dose remained the same for each.

Study of Kadian NT in Subjects With Chronic Moderate to Severe Nonmalignant Pain [Active, not recruiting]

more trials >>

Reports of Suspected Kadian (Morphine) Side Effects

Toxicity TO Various Agents (43)Unresponsive TO Stimuli (40)Completed Suicide (14)Hypotension (14)Pulmonary Oedema (11)Accidental Death (10)Intentional Drug Misuse (10)Drug Abuse (8)Cardio-Respiratory Arrest (8)Brain Oedema (8)more >>


Page last updated: 2015-07-31

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