KADIAN® capsules 20, 30, 50, 60 and 100 mg contain identical polymer coated sustained release pellets of morphine sulfate for oral administration.
KADIAN® is indicated for the management of moderate to severe pain where treatment with an opioid analgesic is indicated for more than a few days (see CLINICAL PHARMACOLOGY;
KADIAN® was developed for use in patients with chronic pain who require repeated dosing with a potent opioid analgesic, and has been tested in patients with pain due to malignant conditions. KADIAN® has not been tested as an analgesic for the treatment of acute pain or in the postoperative setting and is not recommended for such use.
Media Articles Related to Kadian (Morphine)
'Light was as rewarding as morphine' in mice with new opioid receptors
Source: Pain / Anesthetics News From Medical News Today [2015.05.04]
A light-sensitive protein from the retina of the eye, melded to an opioid brain receptor, has induced reward-stimulation in mice - raising early research hopes for safer drugs.
Morphine After Tonsillectomy Tied to Breathing Problems in Study
Source: MedicineNet Tonsillectomy Specialty [2015.01.26]
Title: Morphine After Tonsillectomy Tied to Breathing Problems in Study
Category: Health News
Created: 1/26/2015 12:00:00 AM
Last Editorial Review: 1/26/2015 12:00:00 AM
Exercise Stimulates Pain Modulation in Fibromyalgia
Source: Medscape Medical News Headlines [2015.05.22]
Exercise activates areas of the brain associated with pain modulation, suggesting it could be an effective treatment for fibromyalgia.
Medscape Medical News
Subconscious learning shapes pain responses
Source: Pain / Anesthetics News From Medical News Today [2015.05.22]
In a new study led from Sweden's Karolinska Institutet, researchers report that people can be conditioned to associate images with particular pain responses - such as improved tolerance to pain ...
More Babies Born to Mothers Addicted to Pain Meds
Source: MedicineNet Pregnancy Drug Dangers Specialty [2015.05.22]
Title: More Babies Born to Mothers Addicted to Pain Meds
Category: Health News
Created: 5/22/2015 12:00:00 AM
Last Editorial Review: 5/22/2015 12:00:00 AM
Published Studies Related to Kadian (Morphine)
Evaluation of a single-dose, extended-release epidural morphine formulation for
pain control after lumbar spine surgery. 
DepoDur, an extended-release epidural morphine, has been used effectively for
postoperative pain control following many orthopaedic and general surgery
procedures and has provided prolonged analgesia when compared with Duramorph. The
goal of this article was to compare the safety and analgesic efficacy of DepoDur
versus Duramorph after lumbar spine surgery...
Morphine decreases clopidogrel concentrations and effects: a randomized,
double-blind, placebo-controlled trial. 
effects on platelets... CONCLUSIONS: Morphine delays clopidogrel absorption, decreases plasma levels of
The postoperative analgesic effect of morphine and paracetamol in the patients
undergoing laparotomy, using PCA method. 
CONCLUSION: Morphine seems to be more effective at 2 and 4 hours, but after 4
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus
oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after
total knee arthroplasty. 
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose
Effect of morphine on lower urinary tract discomfort after transurethral
resection of prostate under general anesthesia: a randomised clinical study. 
TURP-related LUT discomfort symptoms... CONCLUSION: Based on these results, we conclude that morphine effectively reduces
Clinical Trials Related to Kadian (Morphine)
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction [Completed]
This study involves approximately 200 patients designed to evaluate the efficacy and safety
of intranasal (IN) morphine 7. 5 mg and 15 mg, intravenous morphine (IV) 7. 5 mg, immediate
release oral (PO) morphine 60 mg or placebo in patients with acute postsurgical pain
following third molar extraction.
A Study of Kadian NT in Subjects With Pain Due to Osteoarthritis of the Hip or Knee [Completed]
The purpose of this study is to evaluate the efficacy of Kadian NT compared with placebo for
treating moderate to severe chronic pain over a 12 week period.
Intrathecal Morphine in Knee Arthroplasty [Completed]
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain
relief and side effect profiles of same in the setting of Total Knee Replacement. We
hypothesized that a dose greater than that used in Total Hip Replacement was needed and
wished to find a dose which was effective but had a low side effect profile.
Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery [Completed]
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray
(MNS075) 3. 75 mg, 7. 5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7. 5 mg, or IN placebo
in patients with moderate to severe post-surgical pain following orthopedic surgery. After
initial dosing, up to six (6) doses of IN MNS075 7. 5 mg or 15 mg for up to twenty-four (24)
hours will be evaluated. The rescue dose remained the same for each.
Study of Kadian NT in Subjects With Chronic Moderate to Severe Nonmalignant Pain [Active, not recruiting]
Reports of Suspected Kadian (Morphine) Side Effects
Toxicity TO Various Agents (43),
Unresponsive TO Stimuli (40),
Completed Suicide (14),
Pulmonary Oedema (11),
Accidental Death (10),
Intentional Drug Misuse (10),
Drug Abuse (8),
Cardio-Respiratory Arrest (8),
Brain Oedema (8), more >>