Natural fruit-flavored K-LOR (potassium chloride for oral solution, USP) is an oral potassium supplement offered in individual packets as a powder for reconstitution. Each packet of K-LOR 20 mEq powder contains potassium 20 mEq and chloride 20 mEq provided by potassium chloride 1.5 g.
For the treatment of patients with hypokalemia with or without metabolic alkalosis, in digitalis intoxication, and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.
The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern, and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and, if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.
Published Studies Related to K-LOR (Potassium Chloride)
A double-blind, randomized, parallel, placebo-controlled study examining the
effect of cross-linked polyelectrolyte in heart failure patients with chronic
kidney disease. 
CONCLUSION: In advanced, symptomatic HF with CKD, CLP is associated with
Efficacy of a commercial dentifrice containing 2% strontium chloride and 5%
potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults
in China. 
silica base without any active ingredient (control dentifrice)... CONCLUSION: In these patients with DH in China, the dentifrice containing 2%
One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study. [2011.04]
OBJECTIVES: Histidine-tryptophan-ketoglutarate (HTK-Custodiol) cardioplegic solution is administered as one single dose for more than 2 hours of ischemia. No prospective randomized clinical study has compared the effects of HTK and cold blood cardioplegia on myocardial damage in elective mitral valve surgery. Thus, the main aim of the present study was to examine whether one single dose of cold antegrade HTK gives as good myocardial protection as repetitive antegrade cold blood cardioplegia in mitral valve surgery... CONCLUSIONS: One single dose of antegrade cold HTK cardioplegic solution in elective mitral valve surgery protects the myocardium equally well as repetitive antegrade cold blood cardioplegia. Copyright (c) 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Improving outcome of treatment of kala-azar by supplementation of amphotericin B with physiologic saline and potassium chloride. [2010.11]
Complications of amphotericin B limit its wide application in the treatment of patients with kala-azar. This study was undertaken with an aim to minimize anti-renal complications and severe rigor in course of treatment with this drug... Supplementation of amphotericin B with 500 mL of physiologic saline and 30 mL (60 meq/L) of KCl during treatment could help prevent an increase in serum creatinine levels and severe rigor and would make the treatment of kala-azar with amphotericin B easier.
Push-out bond strength of mineral trioxide aggregate in the presence of alkaline pH. [2010.11]
INTRODUCTION: The aim of this study was to evaluate the effect of a range of alkaline pH values on the push-out strength of white mineral trioxide aggregate (WMTA)... CONCLUSIONS: Push-out bond strength of WMTA could be influenced by different alkaline pH values. Copyright (c) 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Clinical Trials Related to K-LOR (Potassium Chloride)
Bioavailability of Potassium From Potatoes and Potassium Gluconate [Recruiting]
Potassium in Haemodialysis Fluids and Haemodynamics [Completed]
In a study published in 1995 in the American Journal of Kidney Diseases, Dolson et al
demonstrated that a rapid decrease of serum potassium concentrations during haemodialysis
would produce a significant increase in systolic blood pressure at the end of the session,
even though there were no clear effects on intra-dialytic blood pressure. The authors
defined this post-dialysis blood pressure behaviour as "rebound hypertension".
Paradoxically, in animal models, other than in the context of end-stage renal disease,
potassium is a vasodilator. Considering that the removal of potassium during the
haemodialysis session could be theoretically modulated in profiles (as with sodium and
bicarbonate), it was deemed suitable to delve deeper into this argument by studying, in
detail, the (non invasive) hemodynamic repercussions of changes in the potassium
concentration of the dialysate. Not being able to linearly modify the concentration, we
decided to divide the dialysis session in 3 tertiles, randomising the patients to all
possible dialysate sequences containing the usual concentration of potassium or two cut-off
points at +1 and - 1 mmol/l. Haemodynamic measurements were performed using a finger
Safety of Continuous Potassium Chloride Infusion in Critical Care [Completed]
Patients in critical care often require supplemental potassium chloride if levels in their
blood are below acceptable level. Common practice is to administer a single dose of
potassium chloride under controlled conditions via a drip, before checking if a further dose
is required. The purpose of this study is to ensure that it is safe to administer potassium
chloride continuously with the dose varied according to patient needs.
Comparison of Two Potassium Targets Within the Normal Range in Intensive Care Patients [Completed]
Rationale: It is well known that distinctly abnormal blood potassium values can cause
serious complications such as cardiac arrhythmias. Although potassium regulation is
generally considered important, hardly any research has been done about potassium regulation
in intensive care patients. The investigators hypothesize that different potassium
target-values, within the as normal accepted range, may have different effects in critically
Study design: A prospective trial comparing two different potassium target-values. Potassium
will be tightly regulated with the already fully operational GRIP-II computer program.
Study population: 1200 adult patients admitted at the thoracic intensive care unit of the
University Medical Center Groningen.
Intervention: Comparison between two variations of standard therapy: potassium target-value
of 4. 0 mmol/L versus 4. 5 mmol/L.
Main study parameters/endpoints: The primary endpoint is the incidence of atrial
fibrillation or atrial flutter from ICU-admission to hospital discharge. Secondary endpoints
are serum levels of potassium and the other main electrolytes, renal function and renal
potassium excretion, the relation with insulin and glucose, the cumulative fluid balance,
(ICU) length of stay and mortality.
The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function [Completed]
Page last updated: 2013-02-10