Media Articles Related to Jevtana (Cabazitaxel)
Urologists Dispute Prostate Cancer Screening Recommendation
Source: Medscape Medical News Headlines [2015.05.22]
US Preventive Services Task Force recommendations against prostate screening are among the new payment disagreements arising from the Affordable Care Act and the shift away from fee-for-service.
Medscape Medical News
Scientists unveil prostate cancer's 'Rosetta Stone'
Source: Genetics News From Medical News Today [2015.05.22]
Almost 90 per cent of men with advanced prostate cancer carry genetic mutations in their tumours that could be targeted by either existing or new cancer drugs, a landmark new study reveals.
International study of advanced prostate cancer genome finds potential targets for drug therapy
Source: Genetics News From Medical News Today [2015.05.22]
The first major effort to canvas the genomic landscape of advanced prostate cancer has revealed that many patients may carry some type of genetic abnormality that can be targeted with existing or...
Researchers focus on potential tool for predicting survival, staging prostate cancer
Source: Bones / Orthopedics News From Medical News Today [2015.05.21]
Researchers with the Indiana University School of Medicine have identified a molecule that promotes metastasis of advanced prostate cancer to the bone, an incurable condition that significantly...
Study: MRI Missed 1 in 6 High-Grade Prostate Cancers
Source: Medscape Urology Headlines [2015.05.20]
Men with elevated PSA underwent diagnostic mpMRI and then were double-checked with ultrasound-guided biopsy. The newer tool was not flawless.
Medscape Medical News
Published Studies Related to Jevtana (Cabazitaxel)
TROPIC: Phase III trial of cabazitaxel for the treatment of metastatic castration-resistant prostate cancer. [2011.04]
For patients with metastatic castration-resistant prostate cancer (mCRPC), the current standard of care is chemotherapy involving the tubulin-binding taxane docetaxel. However, as the tumor cells become resistant to docetaxel-based therapy, disease progression is inevitable, and until recently there was no further available treatment beyond palliative care.
Cabazitaxel for the second-line treatment of metastatic hormone-refractory
prostate cancer: a NICE single technology appraisal. 
The National Institute for Health and Clinical Excellence (NICE) invited the
manufacturer of cabazitaxel (Jevtana®, sanofi-aventis, UK) to submit evidence of
its clinical and cost effectiveness for the second-line treatment of metastatic
hormone-refractory prostate cancer (mHRPC)... They concluded that whilst
the clinical effectiveness of cabazitaxel had been proven, it was not likely to
represent a cost-effective use of NHS resources and so its use could not be
Managing side effects of the novel taxane cabazitaxel in castrate-resistant
prostate cancer. 
Cabazitaxel, a novel taxane, was approved in June 2010 by the U.S. Food and Drug
Administration for treatment of metastatic castrate-resistant prostate cancer
(mCRPC) in men previously treated with docetaxel... This article reviews the vital role of nurses in
identifying patients at high risk for AEs associated with cabazitaxel therapy and
reviews strategies for prevention and management of symptoms.
The European Medicines Agency review of cabazitaxel (Jevtana®) for the treatment
of hormone-refractory metastatic prostate cancer: summary of the scientific
assessment of the committee for medicinal products for human use. 
On March 17, 2011 the European Commission issued a marketing authorization valid
throughout the European Union for Jevtana® (Sanofi-Aventis, Paris, France) for
the treatment of patients with hormone-refractory metastatic prostate cancer
previously treated with a docetaxel-containing regimen... The detailed scientific assessment report and
product information, including the summary of product characteristics, are
available on the European Medicines Agency Web site (http://www.ema.europa.eu).
Cabazitaxel: a novel microtubule inhibitor. [2011.07.09]
The development of drug resistance is a major obstacle to effective cancer therapy. Several agents are in clinical development with the goal of overcoming resistance... This article presents the preliminary antitumour activity, safety, tolerability and pharmacokinetic data of cabazitaxel, and an overview of the current status of clinical development.
Clinical Trials Related to Jevtana (Cabazitaxel)
Dose-Escalation, Safety, Pharmacokinetics Study of Cabazitaxel With Gemcitabine In Patients With Solid Tumor [Recruiting]
- Part 1: To determine the Maximum Tolerated Dose (MTD) and the Dose Limiting Toxicities
(DLTs) of cabazitaxel administered as a 1-hour infusion in combination with
gemcitabine, every 3 weeks in patients with advanced solid malignancies.
- Part 2: To determine the antitumor activity of cabazitaxel in combination with
gemcitabine, in an additional extended cohort of 15 patients with advanced solid
malignancies treated with the defined MTD, as assessed by objective response rate (ORR)
according to the revised guideline for Response Evaluation Criteria in Solid Tumours
(RECIST 1. 1 criteria).
- To assess the safety profile of the combination regimen of cabazitaxel with
- To assess the pharmacokinetics (PK) of cabazitaxel, gemcitabine and its metabolite,
and 2,2 difluoridine when given in combination.
- To determine Time to Progression (TTP), Objective Response Rate (ORR), and Duration of
Response (DR), in the extended cohort of patients treated at the MTD in Part 2 of the
study and the patients who received the MTD in Part 1 component.
- To assess the potential inhibitory effect of cabazitaxel on CYP3A4 using midazolam, a
CYP3A4 probe since cabazitaxel inhibits CYP3A4 in vitro.
Cabazitaxel in Men 75 Years of Age or Older With Castration-Resistant Prostate Cancer [Not yet recruiting]
Cabazitaxel is already approved by the Food and Drug Administration (FDA) for use in
patients with advanced prostrate cancer, following docetaxel therapy. The purpose of this
study is to better understand the response and toxicity of cabazitaxel of elderly men (age
75 years and older) with advanced prostate cancer who have progressed during or after
treatment with docetaxel. All patients on this study will receive cabazitaxel by intravenous
(through a vein) infusion plus prednisone by mouth twice daily, and following the
chemotherapy infusions, an injection of a granulocyte colony-stimulating factor (G-CSF).
G-CSF will help the body produce more white blood cells, which should help decrease the risk
of getting an infection while being treated with cabazitaxel.
Phase I/II Cabazitaxel for Recurrent Malignant Glioma [Not yet recruiting]
The goal of Part 1 of this clinical research study is to find the highest tolerable dose of
cabazitaxel that can be given to patients with glioblastoma. The goal of Part 2 is to learn
if cabazitaxel can help to control glioblastoma. The safety of the study drug will also be
studied in both parts.
Cabazitaxel is designed to interfere with the growth of cancer cells by stopping cell
Ph Ib/IIa Study of Cabazitaxel Plus Bavituximab in Castration-resistant Prostate Cancer [Recruiting]
This is a Phase Ib/IIa Study of Cabazitaxel plus Bavituximab in patients with
castration-resistant prostate cancer (CRPC). The current study is designed to determine if
the addition of bavituximab to cabazitaxel will improve progression free survival (PFS) or
overall survival (OS). In addition, the Lead Researcher is requiring the collection of
urine, and blood specimens for future research.
This study will enroll patients with CRPC, who have been previously treated with docetaxel
or a docetaxel-containing regimen. Patients may be intolerant of, or resistant to,
docetaxel, or may have been previously treated with the agent without definite disease
progression during therapy.
Patients must meet the study eligibility criteria and must be competent to give informed
Study of Weekly Cabazitaxel for Advanced Prostate Cancer [Not yet recruiting]
This is a multicenter open label non randomized phase II clinical trial of Weekly
Cabazitaxel for Advanced Prostate Cancer in Hormone-Refractory Patients Previously Treated
The purpose of this study is to evaluate the activity of the weekly administration of
cabazitaxel as time to progression by PSA at week 12.