Media Articles Related to Ixempra (Ixabepilone)
pCR and Improved Survival in Breast Cancer?
Source: Medscape Hematology-Oncology Headlines [2014.09.11]
Dr. Lidia Schapira discusses an analysis of NeoALTTO, which indicates that achieving pCR after neoadjuvant therapy for HER2+ cancer is associated with improved outcomes -- for some more than others.
'Got It Right': Guidelines for HER2-Negative Breast Cancer
Source: Medscape Hematology-Oncology Headlines [2014.09.10]
Dr. Kathy Miller says the ASCO guidelines for advanced HER2-negative breast cancer 'got it right,' focusing on HT, sequential chemo agents, and decisions made jointly by doctors and patients.
New genetic target for a different kind of cancer drug should benefit lung and breast cancer patients
Source: Breast Cancer News From Medical News Today [2014.09.10]
Upstream of the proteins that cancer cells use to proliferate sits RBM4, a gene-splicing protein that UNC researcher Zefeng Wang, PhD, discovered is drastically reduced in human lung and breast...
97 percent of elderly patients aged above 80 years recover without major complications after breast cancer surgery
Source: Breast Cancer News From Medical News Today [2014.09.09]
A study conducted by National Cancer Centre Singapore (NCCS) has shown that age per se is not a contraindication to breast cancer surgery, and such surgeries may be safely performed for women aged 80...
Advance reported in treatment of triple-negative breast cancer
Source: Breast Cancer News From Medical News Today [2014.09.09]
William M. Sikov, a medical oncologist in the Breast Health Center and associate director for clinical research in the Program in Women's Oncology at Women & Infants Hospital of Rhode Island, served...
Published Studies Related to Ixempra (Ixabepilone)
Ixabepilone plus capecitabine in metastatic breast cancer patients with reduced performance status previously treated with anthracyclines and taxanes: a pooled analysis by performance status of efficacy and safety data from 2 phase III studies. [2011.02]
Patients with metastatic breast cancer (MBC) previously treated with anthracyclines and taxanes often have decreased performance status secondary to extensive tumor involvement. Here, we report the pooled analysis of efficacy and safety data from two similarly designed phase III studies to provide a more precise estimate of benefit of ixabepilone plus capecitabine in MBC patients with Karnofsky's performance status (KPS) 70-80...
Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. [2010.07.10]
PURPOSE: We sought to determine whether the combination of ixabepilone plus capecitabine improved overall survival (OS) compared with capecitabine alone in patients with metastatic breast cancer (MBC) previously treated with anthracyclines and taxanes... CONCLUSION: This study confirmed a previous trial demonstrating improved PFS and response for the ixabepilone-capecitabine combination compared with capecitabine alone, although this did not result in improved survival.
Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes. [2010.07]
Limited proven treatment options exist for patients with metastatic breast cancer (MBC) resistant to anthracycline and taxane treatment.A clinical benefit was also seen in patients in the KPS 70-80 subgroup.
Activity of ixabepilone in oestrogen receptor-negative and oestrogen receptor-progesterone receptor-human epidermal growth factor receptor 2-negative metastatic breast cancer. [2009.11]
Oestrogen receptor (ER)-negative breast cancer, including oestrogen receptor-, progesterone receptor- and human epidermal growth factor receptor 2-negative (ER/PR/HER2-negative) breast cancer, is more aggressive than ER-positive disease. A major limitation in the treatment of ER-negative disease subtypes is the inherent insensitivity to hormonal agents (tamoxifen, aromatase inhibitors) that are widely used in the treatment of breast cancer...
Cost effectiveness of ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. [2009.05.01]
PURPOSE: Using data from a recent randomized trial, we evaluated the cost effectiveness of ixabepilone plus capecitabine versus capecitabine alone in patients with predominantly metastatic breast cancer considered to be taxane-resistant and previously treated with or resistant to an anthracycline... CONCLUSION: Addition of ixabepilone to capecitabine adds approximately $31,000 to overall medical costs and affords approximately 1 additional month of quality-adjusted survival.
Clinical Trials Related to Ixempra (Ixabepilone)
Phase I/II Trial of Sorafenib Plus Ixabepilone in HER2-Negative Metastatic Breast Cancer [Recruiting]
In this study, patients with metastatic HER2-negative breast cancer will receive treatment
with ixabepilone and sorafenib until disease progression or unacceptable toxicity occurs.
The Phase I portion of this study will determine the maximum tolerated doses (MTDs) of
sorafenib and ixabepilone that may be used in combination for first- or second-line
treatment of MBC. The MTDs identified in the Phase I portion of the study will be used in
the Phase II portion which will evaluate the efficacy and safety of the combination of
sorafenib and ixabepilone in patients who have received at least one prior chemotherapy
treatment in either the adjuvant or neoadjuvant setting or following one prior MBC
chemotherapy in MBC patients who had not received prior adjuvant or neoadjuvant breast
cancer chemotherapy. This will be one of the initial trials investigating the use of this
treatment combination for MBC.
This trial will be conducted under the leadership of the Sarah Cannon Research Institute
(SCRI) Oncology Research Consortium, a community-based, multi-center, clinical trial
Ixabepilone to Treat Cervical Cancer [Recruiting]
- Ixabepilone is a member of the class of drugs called epithilones. These drugs interfere
with the ability of cancer cells to replicate.
- Epithilones are similar to taxanes, another class of drugs, which includes the drug
Taxol. Taxol is widely used to treat a variety of cancers.
- Ixabepilone can work in cells that are resistant to Taxol.
- To determine whether ixabepilone is effective for treating cervical cancer.
- Women 18 years of age or older with cervical cancer.
- Patients receive ixabepilone intravenously (through a vein) over 60 minutes on the
first 5 days of each 21-day treatment cycle. Their dosage may be adjusted according to
how their bodies respond to the drug.
- The number of cycles each woman receives depends on her response to the treatment.
- Patients have CT scans and other tests before starting treatment and then every other
treatment cycle to determine the response of the tumor to ixabepilone.
- Patients who can undergo a tumor biopsy (surgical removal of a sample of tumor tissue)
are asked to have a biopsy done before starting treatment with ixabepilone and again on
the fourth or fifth day of treatment. This procedure is optional.
Ixabepilone and Cyclophophamide as Neoadjuvant Therapy in HER-2 Negative Breast Cancer [Recruiting]
We propose to evaluate ixabepilone in combination with cyclophosphamide for the neoadjuvant
treatment of locally advanced breast cancer. In this regimen, ixabepilone is substituted for
docetaxel, since preclinical and clinical studies suggest that ixabepilone is more active
than either docetaxel or paclitaxel. The combination of ixabepilone and cyclophosphamide
could further improve the efficacy of non-anthracycline neoadjuvant therapy.
A Study of Ixabepilone as Second Line Therapy for Locally Advanced, Recurrent or Metastatic Endometrial Cancer [Recruiting]
The primary purpose of this study is to investigate whether administration of ixabepilone
results in superior outcome as measured by overall survival compared to standard
chemotherapy (Paclitaxel or Doxorubicin) in women with advanced endometrial cancer that
progressed after first line chemotherapy
Neoadjuvant Ixabepilone/Carboplatin/Trastuzumab in HER2-Positive Locally Advanced Breast Cancer [Recruiting]
In this phase II trial the investigators propose to evaluate ixabepilone in combination with
carboplatin and trastuzumab as neoadjuvant therapy in locally advanced breast cancer
patients. Patients with early stage, HER2-positive breast cancer will receive six cycles of
neoadjuvant treatment with ixabepilone, carboplatin, and trastuzumab every three weeks prior
to surgery; after surgery, patients will continue treatment with trastuzumab every three
weeks until week 52. Concomitant with the post-operative trastuzumab treatment, patients
with hormone receptor-positive tumors will receive anti-estrogen treatment. Also, after the
completion of chemotherapy, patients may receive radiation treatment at the discretion of