NEWS HIGHLIGHTS
Published Studies Related to Isuprel (Isoproterenol Intracardiac)
Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness. [2009.04]
Interoception, defined as the perception of internal body states, plays a central role in classic and contemporary theories of emotion... These findings indicate that bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness, which sets a foundation for further investigation of the role of interoceptive sensations in the experience of emotion.
Electrical storm reversible by isoproterenol infusion in a striking case of early repolarization. [2009.08]
A 40-year-old woman was referred to intensive care unit after recurrent ventricular fibrillation. She was free of cardiac medical history or medications... This case report demonstrates the usefulness and efficiency of the isoproterenol infusion to eliminate recurrent ventricular fibrillation in patients with early repolarization.
Endoluminal isoproterenol reduces renal pelvic pressure during semirigid ureterorenoscopy: a porcine model. [2009.06.24]
OBJECTIVE To investigate the effects on the pressure-flow relation of renal pelvic pressure during semirigid ureterorenoscopy and endoluminal perfusion of isoproterenol (ISO) 0.1 microg/mL, with emphasis on local effects and cardiovascular side-effects, as topically administered ISO effectively and dose-dependently causes relaxation of the upper urinary tract in pigs with no concomitant cardiovascular side-effects...
Ventricular premature depolarizations triggered by incremental dose isoproterenol infusion: common electrocardiographic features. [2009.06]
PURPOSE: To identify the prevalence of adrenergically mediated ventricular premature depolarizations (VPDs) and characterize their electrocardiographic (ECG) features and specific anatomically determined sites of origin within the ventricles... CONCLUSION: Adrenergically mediated VPDs are frequent in patients without structural heart disease or VT and tend to originate from a few anatomic sites.
Isoproterenol improves secretion of transplanted submandibular glands. [2009.05]
Autotransplantation of the submandibular gland is effective for severe keratoconjunctivitis sicca. However, most transplants show decreased secretion shortly after the operation, which leads to obstruction of Wharton's duct...
Clinical Trials Related to Isuprel (Isoproterenol Intracardiac)
Vascular Response to Isoproterenol and β2 Adrenergic Receptor Polymorphisms [Completed]
Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic
receptor (ß2AR) modify its pharmacological properties and may alter the response to ß2AR
agonists. The goal of the present study was to evaluate the role played by the Arg16Gly and
Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries
segments ex-vivo.
Internal mammary leftover segments were collected from 96 patients undergoing coronary artery
bypass graft operation. Four rings that were prepared from each specimen were allowed to
reach equilibrium with physiological Krebs solution prior to precontraction with U46619.
Using the organ bath technique, cumulative dose response curve of isoproterenol was
constructed and mean EC50 calculated for each patient.
Isoproterenol Challenge to Detect Arrhythmogenic Right Ventricular Cardiomyopathy [Completed]
This study will examine the usefulness of a new test called an isoproterenol challenge in
patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and family members who
may have the disease but do not have clear-cut evidence of it. ARVC is a rare condition that
runs in families. Heart muscle is replaced with fatty, scar-like tissue, especially in the
right ventricle (lower pumping chamber of the heart), and can sometimes extend to the left
ventricle (the main pumping chamber). The fat can interfere with the heartbeat, producing
abnormal heart rhythms, such as ventricular tachycardia (VT) - a very fast heartbeat that can
cause sudden death, especially in young people. Isoproterenol is a drug that increases heart
rate and heart muscle contractions. In isoproterenol challenge, subjects are given increasing
doses of the drug through a catheter (see details below) to try to produce an abnormal heart
rhythm.
ARVC is hard to diagnose with current tests. This study will see if isoproterenol challenge
provokes VT in patients with the disease and can confirm the diagnosis; if it can detect the
disease in family members better than currently available tests; and if it provokes abnormal
rhythms in healthy control subjects. In addition, the study will explore the genetics of ARVC
and determine whether infection could contribute to its development.
Patients with ARVC, their family members, and normal volunteers 18 years of age and older may
be eligible for this study. Candidates are screened with a medical history and physical
examination, electrocardiogram (EKG), treadmill and bicycle exercise testing, and an
echocardiogram (ultrasound test of the heart).
Participants undergo the following tests and procedures:
- Blood tests - Blood is collected to study the genetics of ARVC, to test for evidence of old infections, and to measure brain natriuretic peptide - a hormone that can increase
with development of heart failure.
- Heart magnetic resonance imaging (MRI). This test looks at heart structure and function.
MRI uses a magnetic field and radio waves to produce images of body tissues and organs.
The subject lies on a table that is moved into the scanner (a narrow cylinder), wearing
earplugs to muffle loud knocking sounds that occur during the scanning process. At some
time during the test, the subject is given a contrast agent called gadolinium through a
catheter (thin, flexible tube) in a vein to improve the scan pictures. The scan time
varies from 30 to 90 minutes, with most scans lasting 60 minutes. (Control subjects do
not undergo MRI.)
- Isoproterenol challenge. Subjects are given increasing doses of isoproterenol through a
catheter until the heart rate reaches 100 to 120 beats per minute for no more than 1
hour. A special EKG records heart rhythm during the test and an echocardiogram records
right and left ventricular function.
- QRST surface mapping EKG. This special EKG, done with 64 or 120 leads, maps
abnormalities of heart rhythm and cardiac conduction during the isoproterenol challenge.
These tests are like a regular EKG, except that more leads are placed on the chest, and
on the back as well.
Patients and family members who wish to have follow-up visits may return to the NIH Clinical
Center once a year for 5 years for guidance about therapy based on clinical considerations
and new information or investigations.
Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas [Recruiting]
The purpose of this study is to test whether injected medications will increase the amount
of fat released by a fat cell. We will compare prednisolone (a synthetic cortisone)
combined with isoproterenol (a drug given for asthma) versus using isoproterenol alone. We
will also test if injections of isoproterenol and prednisolone will shrink the size of
lipomas, which are benign fatty tumors.
Pharmacological Modulation of the Intrarenal Pressure During Endourological Procedures in the Upper Urinary Tract [Completed]
The purpose of the study is to examine the effect of endoluminally administrated
isoproterenol on pelvic pressure increase during flexible ureterorenoscopy in 14 humans. We
propose that isoproterenol has potential of reducing intrarenal pressure during
ureterorenoscopies. Lower intrarenal pressures may have the advantage of facilitating the
procedure and reducing intraoperative complications as bleeding and infections.
Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone [Active, not recruiting]
Is it possible to decrease the intrarenal pressure in the kidney during endoscopic management
of kidney stone by topical administration of drugs? In order to secure fewer complications in
ureteroscopic operations the pharmacological agent isoproterenol is tested on pigs and human
to determine its potential of lowering intrarenal pressure.
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