DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Iopidine (Apraclonidine Hydrochloride Ophthalmic) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

In clinical studies the overall discontinuation rate related to IOPIDINE 0.5% Ophthalmic Solution was 15%. The most commonly reported events leading to discontinuation included (in decreasing order of frequency) hyperemia, pruritus, tearing, discomfort, lid edema, dry mouth, and foreign body sensation.

The following adverse reactions (incidences) were reported in clinical studies of IOPIDINE 0.5% (apraclonidine ophthalmic solution) as being possibly, probably, or definitely related to therapy:

Ocular

The following adverse reactions were reported in 5 to 15% of the patients: discomfort, hyperemia, and puritus. The following adverse reactions were reported in 1 to 5% of the patients: blanching, blurred vision, conjunctivitis, discharge, dry eye, foreign body sensation, lid edema, and tearing.

The following adverse reactions were reported in less than 1% of the patients: abnormal vision, blepharitis, blepharoconjunctivitis, conjunctival edema, conjunctival follicles, corneal erosion, corneal infiltrate, corneal staining, edema, irritation, keratitis, keratopathy, lid disorder, lid erythema, lid margin crusting, lid retraction, lid scales, pain, photophobia.

Nonocular

Dry mouth occurred in approximately 10% of the patients.

The following adverse reactions were reported in less than 3% of the patients: abnormal coordination, asthenia, arrhythmia, asthma, chest pain, constipation, contact dermatitis, depression, dermatitis, dizziness, dry nose, dyspnea, facial edema, headache, insomnia, malaise, myalgia, nausea, nervousness, paresthesia, parosmia, peripheral edema, pharyngitis, rhinitis, somnolence, and taste perversion.

Clinical practice: The following events have been identified during post-marketing use of IOPIDINE® 0.5% Ophthalmic Solution in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The events, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to IOPIDINE 0.5% Ophthalmic Solution, or a combination of these factors, include: bradycardia.



REPORTS OF SUSPECTED IOPIDINE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Iopidine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Iopidine side effects / adverse reactions in 98 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-01-13

Patient: 98 year old female

Reactions: Malaise, Overdose, Impaired Self-Care, Atrioventricular Block Complete, Condition Aggravated, Bradycardia

Adverse event resulted in: hospitalization

Suspect drug(s):
Duotrav Ophthalmic Solution (Duotrav)
    Dosage: once daily ophthalmic
    Start date: 2009-01-01
    End date: 2011-07-04

Iopidine
    Dosage: bid ophthalmic
    Start date: 2009-01-01
    End date: 2011-07-04

Other drugs received by patient: Calcium Carbonate; Lansoyl; Imovane



Possible Iopidine side effects / adverse reactions in 82 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-11

Patient: 82 year old male

Reactions: Retinal Pigment Epithelial Tear

Suspect drug(s):
Iopidine
    Dosage: (bid ophthalmic)
    Start date: 2011-02-02
    End date: 2011-02-20

Lacrigel (Lacrigel) (Farmigea S.p.a.)
    Dosage: (tid)
    Start date: 2011-02-02
    End date: 2011-02-06

Lucentis
    Dosage: )10 mg/ml 1 administration per month)
    Indication: AGE-Related Macular Degeneration
    Start date: 2011-02-02

Ofloxacin
    Dosage: (bid)
    Start date: 2011-02-01
    End date: 2011-02-06

Other drugs received by patient: Pentoxifylline; Alfuzosin HCL; Permixon



Possible Iopidine side effects / adverse reactions in 85 year old female

Reported by a physician from United Kingdom on 2012-06-13

Patient: 85 year old female

Reactions: Paradoxical Drug Reaction, Intraocular Pressure Increased

Suspect drug(s):
Acetazolamide
    Dosage: (500 mg intravenous (not otherwise specified)), (250 mg qid), (125 mg qid)
    Indication: Angle Closure Glaucoma

Azopt
    Dosage: tid ophthalmic
    Indication: Angle Closure Glaucoma

Iopidine
    Dosage: tid ophthalmic
    Indication: Eye Disorder

Isopto Carpine
    Dosage: ophthalmic
    Indication: Angle Closure Glaucoma

Pred Forte
    Dosage: (qid)
    Indication: Angle Closure Glaucoma

Other drugs received by patient: Metoclopramide; Voltaren



See index of all Iopidine side effect reports >>

Drug label data at the top of this Page last updated: 2011-07-05

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017