INVANZ (Ertapenem for Injection) is a sterile, synthetic, parenteral, 1-(beta) methyl-carbapenem that is structurally related to beta-lactam antibiotics.
INVANZ is indicated for the treatment of adult patients with the following moderate to severe infections caused by susceptible strains of the designated microorganisms. (See DOSAGE AND ADMINISTRATION):
Complicated Intra-abdominal Infections due to
Escherichia coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus
Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron,
Complicated Skin and Skin Structure Infections due to
(methicillin susceptible strains only), Streptococcus pyogenes, Escherichia coli,
Community Acquired Pneumonia due to
(penicillin susceptible strains only) including cases with concurrent bacteremia,
(beta-lactamase negative strains only), or
Complicated Urinary Tract Infections including pyelonephritis due to
including cases with concurrent bacteremia, or
Acute Pelvic Infections including postpartum endomyometritis, septic abortion and post surgical gynecologic infections due to
Streptococcus agalactiae, Escherichia coli, Bacteroides fragilis, Porphyromonas asaccharolytica, Peptostreptococcus
Appropriate specimens for bacteriological examination should be obtained in order to isolate and identify the causative organisms and to determine their susceptibility to ertapenem. Therapy with INVANZ (ertapenem) may be initiated empirically before results of these tests are known; once results become available, antimicrobial therapy should be adjusted accordingly.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of INVANZ and other antibacterial drugs, INVANZ should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Published Studies Related to Invanz (Ertapenem)
A prospective, multi centre, randomized clinical study to compare the efficacy and safety of Ertapenem 3 days versus Ampicillin-Sulbactam 3 days in the treatment of localized community acquired intra-abdominal infection. (T.E.A. Study: Three days Ertapenem vs three days Ampicillin-sulbactam). [2011.04.18]
BACKGROUND: The recommendations outlined in the latest guidelines published by the Surgical Infection Society (SIS) and the Infectious Disease Society of America (IDSA) regarding the proper duration of antibiotic therapy in patients with intra-abdominal infections are limited and non-specific.
Infection after elective colorectal surgery: bacteriological analysis of failures in a randomized trial of cefotetan vs. ertapenem prophylaxis. [2009.04]
BACKGROUND: A randomized study comparing single-dose cefotetan and ertapenem prophylaxis for elective colorectal surgery in 1,002 patients found ertapenem to be significantly more effective (p < 0.001). Failures of prophylaxis were thought to involve organisms resistant to both antimicrobial agents, isolated most often from deep or superficial incision sites... CONCLUSIONS: The in vitro activity of ertapenem was superior to that of cefotetan against all anaerobic and many aerobic bacteria isolated from postoperative cultures of patients who failed prophylaxis with these agents. Our findings help to elucidate the results of the clinical trial.
Ertapenem or ticarcillin/clavulanate for the treatment of intra-abdominal infections or acute pelvic infections in pediatric patients. [2007.09]
BACKGROUND: Ertapenem, a group I carbapenem antibiotic, has been shown to be safe and effective in treating adults with complicated intra-abdominal (cIAI) or acute pelvic infection (API). This study evaluated ertapenem for treating these infections in children... CONCLUSIONS: This study suggests that ertapenem is generally safe and efficacious for treating cIAI or API in pediatric patients.
Ertapenem versus cefotetan prophylaxis in elective colorectal surgery. [2006.12.21]
BACKGROUND: Ertapenem, a long-acting carbapenem, may be an alternative to the recommended prophylactic antibiotic cefotetan... CONCLUSIONS: Ertapenem is more effective than cefotetan in the prevention of surgical-site infection in patients undergoing elective colorectal surgery but may be associated with an increase in C. difficile infection. (ClinicalTrials.gov number, NCT00090272 [ClinicalTrials.gov].). Copyright 2006 Massachusetts Medical Society.
Efficacy and safety of ertapenem versus piperacillin-tazobactam for the treatment of intra-abdominal infections requiring surgical intervention. [2006.04]
Complicated intra-abdominal infections usually mandate prompt surgical intervention supplemented by appropriate antimicrobial therapy. The aim of this study was to demonstrate that ertapenem was not inferior to piperacillin-tazobactam for the treatment of community-acquired intra-abdominal infections...
Clinical Trials Related to Invanz (Ertapenem)
Pharmacokinetics of Ertapenem in Continuous Venovenous Hemodialysis [Recruiting]
Critically ill patients in the intensive care unit often receive continuous hemodialysis to
treat their kidney failure. Ertapenem is an antibiotic often used in these patients.
Continuous dialysis may remove ertapenem, putting patients at risk for inappropriate
treatment of their infection. This study will determine how much ertapenem is removed by
Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056) [Recruiting]
The purpose of this study is to evaluate the efficacy and safety of ertapenem sodium
compared to ceftriaxone sodium/metronidazole for the prophylaxis of surgical site infection
following elective colorectal surgery in Chinese adults. This study is designed to
demonstrate that ertapenem sodium is non-inferior to ceftriaxone sodium/metronidazole in
this participant population.
Study to Compare TP-434 and Ertapenem in CA Complicated Intra-abdominal Infections [Recruiting]
This is a Phase 2, randomized, double-blind, double-dummy, multicenter, prospective study to
assess the efficacy, safety, and pharmacokinetics of two dose regimens of TP-434 compared
with ertapenem in the treatment of adult community-acquired complicated intra-abdominal
Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061) [Recruiting]
This study will compare ertapenem sodium to piperacillin/tazobactam sodium for the treatment
of moderate to severe diabetic foot infections.
Ertapenem Pharmacokinetics in Patients in Continuous Ambulatory Peritoneal Dialysis [Recruiting]
Reports of Suspected Invanz (Ertapenem) Side Effects
Clostridial Infection (10),
Confusional State (9),
Hallucination, Visual (8),
Drug Ineffective (6),
Posterior Reversible Encephalopathy Syndrome (6),
Enterococcal Infection (5),
Drug Interaction (5), more >>
Page last updated: 2011-12-09