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Intuniv (Guanfacine Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc



Guanfacine is primarily metabolized by CYP3A4 and its plasma concentrations can be affected significantly by CYP3A4 inhibitors or inducers (Figure 1). Dose adjustments are recommended. Guanfacine does not significantly affect exposures of methylphenidate and lisdexamfetamine when coadministered (Figure 2). Therefore, no dose adjustments in methylphenidate or lisdexamfetamine are necessary. [] see Dosage and Administration

Figure 1: Impact of Other Drugs on the Pharmacokinetics (PK) of Intuniv

Figure 2: Impact of Intuniv on the Pharmacokinetics (PK) of Other Drugs



Post-marketing reports of guanfacine overdosage indicate that hypotension, drowsiness, lethargy, and bradycardia have been observed following overdose. Initial hypertension may develop early and may be followed by hypotension.  Similar symptoms have been described in voluntary reports to the American Association of Poison Control Center’s National Poison Data System. Miosis of the pupils may be noted on examination No fatal overdoses of guanfacine have been reported in published literature. .


Consult a Certified Poison Control Center by calling 1-800-222-1222 for up to date guidance and advice. 

Management of INTUNIV overdose should include monitoring for and the treatment of initial hypertension, if that occurs, as well as hypotension, bradycardia, lethargy and respiratory depression. Children and adolescents who develop lethargy should be observed for the development of more serious toxicity including coma, bradycardia and hypotension for up to 24 hours, due to the possibility of delayed onset hypotension. ®


Patients with a history of hypersensitivity to INTUNIV, its inactive ingredients or other products containing guanfacine should not take INTUNIV. ® [ ] see Description ®


Controlled Substance

INTUNIV is not a controlled substance and has no known potential for abuse or dependence. ®

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