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Indocin (Indomethacin) - Summary

 

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INDOCIN SUMMARY

INDOCIN (Indomethacin) cannot be considered a simple analgesic and should not be used in conditions other than those recommended under INDICATIONS.

Indomethacin has been found effective in active stages of the following:

  1. Moderate to severe rheumatoid arthritis including acute flares of chronic disease.
  2. Moderate to severe ankylosing spondylitis.
  3. Moderate to severe osteoarthritis.
  4. Acute painful shoulder (bursitis and/or tendinitis).
  5. Acute gouty arthritis.

INDOCIN may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis. In such instances the steroid dosage should be reduced slowly and the patients followed very closely for any possible adverse effects.

The use of INDOCIN in conjunction with aspirin or other salicylates is not recommended. Controlled clinical studies have shown that the combined use of INDOCIN and aspirin does not produce any greater therapeutic effect than the use of INDOCIN alone. Furthermore, in one of these clinical studies, the incidence of gastrointestinal side effects was significantly increased with combined therapy (see DRUG INTERACTIONS).

INDOCIN NEWS HIGHLIGHTS

Published Studies Related to Indocin (Indomethacin)

Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial. [2008.08]

Increased Indomethacin Dosing for Persistent Patent Ductus Arteriosus in Preterm Infants: A Multicenter, Randomized, Controlled Trial. [2008.03.18]

Effect of unspecific inhibition of cyclooxygenase by indomethacin on retinal and choroidal blood flow. [2008.03]

Comparison of oral ibuprofen and indomethacin on closure of patent ductus arteriosus in preterm infants. [2008.03]

Prevention and 18-month outcomes of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms. [2008.02]

more>>

Clinical Trials Related to Indocin (Indomethacin)

Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) [Completed]

Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants [Recruiting]

A Double-Blind Study to Determine if Intraduodenal Indomethacin Can Decrease the Incidence of Post-ERCP Pancreatitis [Recruiting]

Comparison of 2 Different Indomethacin Dosing Protocols to Treat Infants Delivered at <28 Weeks Gestation With a Persistent Patent Ductus Arteriosus [Completed]

The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal [Recruiting]

more>>

Page last updated: 2008-08-10

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