Inderal (Propranolol Hydrochloride) - Summary

INDERAL SUMMARY

Inderal (propranolol hydrochloride) is a synthetic beta-adrenergic receptor-blocking agent.

Inderal LA is indicated in the management of hypertension; it may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Inderal LA is not indicated in the management of hypertensive emergencies.

Inderal LA is indicated for the long-term management of patients with angina pectoris.

Inderal LA is indicated for the prophylaxis of common migraine headache. The efficacy of propranolol in the treatment of a migraine attack that has started has not been established, and propranolol is not indicated for such use.

Inderal LA is useful in the management of hypertrophic subaortic stenosis, especially for treatment of exertional or other stress-induced angina, palpitations, and syncope. Inderal LA also improves exercise performance. The effectiveness of propranolol hydrochloride in this disease appears to be due to a reduction of the elevated outflow pressure gradient, which is exacerbated by beta-receptor stimulation. Clinical improvement may be temporary.

See all indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Inderal (Propranolol)

Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more. [2009.09.01]
CONCLUSIONS: Low-dose oral propranolol significantly attenuated tachycardia and improved symptoms in POTS. Higher-dose propranolol did not further improve, and may worsen, symptoms.

Addition of propranolol and isosorbide mononitrate to endoscopic variceal ligation does not reduce variceal rebleeding incidence. [2009.09]
BACKGROUND & AIMS: Endoscopic variceal ligation (EVL) and propranolol are standard secondary prophylaxis therapies for variceal bleeding. Addition of isosorbide mononitrate (ISMN) to propranolol improves its hemodynamic efficacy; we investigated whether a combination of EVL and propranolol/ISMN was more effective than EVL alone for secondary prophylaxis... CONCLUSIONS: EVL alone is sufficient to prevent variceal rebleeding in cirrhotic and noncirrhotic patients with history of variceal bleeding. Addition of propranolol and ISMN to EVL does not reduce the incidence of variceal rebleeding but increases severe adverse effects. Risk factors for rebleeding include ascites, low serum albumin, and high hepatic venous pressure gradients.

The beta-adrenergic antagonist propranolol partly abolishes thermogenic response to bioactive food ingredients. [2009.08]
A combination of tyrosine, capsaicin, catechins, and caffeine has been shown to possess a thermogenic effect in humans. The present objective was to investigate whether the thermogenic response to the bioactive combination (BC) could be diminished or abolished by propranolol... The 50% reduction of the thermogenic response by propranolol indicates that beta-adrenergic pathways are partly responsible for the thermogenic response.

Zolmitriptan compared to propranolol in the treatment of acute neuroleptic-induced akathisia: a comparative double-blind study. [2009.07]
Neuroleptic-induced akathisia (NIA) is a common, sometimes incapacitating adverse effect of anti-psychotic medication... Further placebo-controlled studies are warranted.

Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers. [2009.07]
RATIONALE: The human pupil may be a suitable physiological test system for the assessment of excessive daytime sleepiness (EDS), but pupillometric assessment could be confounded by medication for comorbid hypertension and mood disorders. OBJECTIVES: We examined the profile of the 5HT-2/alpha1/H1 antagonist ketanserin, the 5HT1a agonist buspirone and the beta adrenoceptor antagonist propranolol on pupillary and other measures of arousal... CONCLUSIONS: Ketanserin but not propranolol had a fully sedative profile and may confound pupillometric assessment of EDS. Beta adrenergic receptors do not appear to participate in arousal and pupillary functions, while 5HT1a receptors reduce pupil size without affecting arousal. Pupil size may not be used unequivocally as an index of the level of alertness in the case of drug-induced changes, when drugs interfere with the central pupil control mechanism in ways that are unrelated to their effects on arousal.

more studies >>

Clinical Trials Related to Inderal (Propranolol)

Bioavailability Study of Propranolol Under Fasting Conditions [Completed]
To compare the single-dose bioavailability of Propranolol 160 Mg ER capsules with Inderal-La

Bioavailability Study of Propranolol Under Fed Conditions [Completed]
To compare the single-dose bioavailability of Propranolol 160 Mg ER Capsules with Inderal-La

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft [Completed]

Food Study of Propranolol Hydrochloride Extended-Release Capsules 160 mg and Inderal® LA Capsules 160 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's propranolol hydrochloride extended-release 160 mg capsules to Wyeth's Inderal® LA 160 mg capsules following a single, oral 160 mg (1 x 160 mg) dose administered under fed conditions.

Fasting Study of Propranolol Hydrochloride Extended-Release Capsules 160 mg and Inderal® LA Capsules 160 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's propranolol hydrochloride extended-release 160 mg capsules to Wyeth's Inderal LA® 160 mg capsules following a single, oral 160 mg (1 x 160 mg) dose administration under fasting conditions.

more trials >>

PATIENT REVIEWS / RATINGS / COMMENTS

Inderal review by 30 year old male patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		situational anxiety
Dosage & duration:		40mg daily as needed taken few times per month for the period of past 6 years
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		I've used 40mg Inderal for situational anxiety a few times per month over the past 6 years. I found it to be very effective when taken 30min to 1hr prior to public speaking, large social gatherings, dates, and other anxiety provoking situations. It really helps decrease signs of nervousness resulting from the fight-or-flight response, such as increased heart rate, sweaty palms, and dry mouth.
Side effects:		none
Comments:		as above

Inderal review by 58 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		essential tremor
Dosage & duration:		10 mg taken tid prn for the period of 22 years
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		The tremor is most noticable in my hands, with fatigue my head also becomes tremulous. Inderal is the most effective medication I have taken to control the tremor. Benzodiazipines were tried early on and were ineffective.
Side effects:		I have not experienced any side effects from Inderal. At one time I was given a medication for another problem which had hypotension as a side effect. That drug and the blood pressure lowering effect of inderal caused a syncopal episode.
Comments:		When I first noticed the tremor I was seen by a family practice physician who started me on valium to treat the problem. With the valium I was tremulous and sleepy. I saw a neurologist who diagnosed the problem and started me on a different benzodiazipine. It was also ineffective. I am a R.N. I did some research on my own and ask my family M.D. if I could stop the benzo. and try Inderal. He ordered it and it has been an effective treatment for many years. I only take it when the tremor interfers with activities.

Inderal review by 58 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		essential tremor
Dosage & duration:		10 mg taken tid prn for the period of 22 years
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		The tremor is most noticable in my hands, with fatigue my head also becomes tremulous. Inderal is the most effective medication I have taken to control the tremor. Benzodiazipines were tried early on and were ineffective.
Side effects:		I have not experienced any side effects from Inderal. At one time I was given a medication for another problem which had hypotension as a side effect. That drug and the blood pressure lowering effect of inderal caused a syncopal episode.
Comments:		When I first noticed the tremor I was seen by a family practice physician who started me on valium to treat the problem. With the valium I was tremulous and sleepy. I saw a neurologist who diagnosed the problem and started me on a different benzodiazipine. It was also ineffective. I am a R.N. I did some research on my own and ask my family M.D. if I could stop the benzo. and try Inderal. He ordered it and it has been an effective treatment for many years. I only take it when the tremor interfers with activities.