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Inderal (Propranolol Hydrochloride) - Summary

 
 



INDERAL SUMMARY

Inderal (propranolol hydrochloride) is a synthetic beta-adrenergic receptor-blocking agent.

Inderal LA is indicated in the management of hypertension; it may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Inderal LA is not indicated in the management of hypertensive emergencies.

Inderal LA is indicated for the long-term management of patients with angina pectoris.

Inderal LA is indicated for the prophylaxis of common migraine headache. The efficacy of propranolol in the treatment of a migraine attack that has started has not been established, and propranolol is not indicated for such use.

Inderal LA is useful in the management of hypertrophic subaortic stenosis, especially for treatment of exertional or other stress-induced angina, palpitations, and syncope. Inderal LA also improves exercise performance. The effectiveness of propranolol hydrochloride in this disease appears to be due to a reduction of the elevated outflow pressure gradient, which is exacerbated by beta-receptor stimulation. Clinical improvement may be temporary.


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NEWS HIGHLIGHTS

Media Articles Related to Inderal (Propranolol)

Proliferating infantile haemangioma: indication of major added benefit from propranolol in certain patients
Source: Dermatology News From Medical News Today [2014.12.09]
Study only included children at risk of scars or disfigurement / No added benefit proven for further subpopulationsThe Institute for Quality and Efficiency in Health Care (IQWiG) investigated in...

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Published Studies Related to Inderal (Propranolol)

The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infants. [2012]
CONCLUSIONS: There was no difference in SVT recurrence in infants treated with

Status of propranolol for treatment of infantile hemangioma and description of a randomized clinical trial. [2011.10]
OBJECTIVES: Our primary objective was to review the current use of propranolol for treatment of infantile hemangioma (IH), specifically regarding 1) the age at initiation of therapy, 2) the method of initiation, 3) the use of other adjuvant therapy, 4) the duration of therapy and relapse rate, 5) the adverse events, and 6) the outcome. Our secondary objective was to describe a randomized, controlled, single-blinded trial comparing propranolol to prednisolone for treatment of IH... CONCLUSIONS: Propranolol is an attractive alternative to other treatments for IH. Despite apparent widespread use of this medication, the data are limited, and prospective studies are lacking for this indication. The relatively high rate of adverse effects supports the need for careful monitoring of patients on this therapy. Fastidious reporting of adverse events and objective evaluation of early and late outcomes are necessary to improve our understanding of the use of propranolol for this indication.

A randomized controlled trial of propranolol for infantile hemangiomas. [2011.08]
OBJECTIVE: Propranolol hydrochloride is a safe and effective medication for treating infantile hemangiomas (IHs), with decreases in IH volume, color, and elevation... CONCLUSION: Propranolol hydrochloride administered orally at 2 mg/kg per day reduced the volume, color, and elevation of focal and segmental IH in infants younger than 6 months and children up to 5 years of age.

Endoscopic variceal band ligation compared with propranolol for prophylaxis of first variceal bleeding. [2011.04]
Administration of nonselective beta-blockers in prophylaxis of first variceal bleeding is not suitable for all patients. Thus, we evaluated endoscopic variceal band ligation (EVBL) in primary prevention of bleeding in patients with cirrhosis and large esophageal varices... In conclusion, EVBL was an effective and safe alternative to propranolol in primary prophylaxis of bleeding in patients with large esophageal varices.

Effect of propranolol on word fluency in autism. [2011.03]
OBJECTIVE AND BACKGROUND: Autism is characterized by repetitive behaviors and impaired socialization and communication. Preliminary evidence showed possible language benefits in autism from the beta-adrenergic antagonist propranolol. Earlier studies in other populations suggested propranolol might benefit performance on tasks involving a search of semantic and associative networks under certain conditions. Therefore, we wished to determine whether this benefit of propranolol includes an effect on semantic fluency in autism... CONCLUSIONS: Results are consistent with a selective beneficial effect of propranolol on flexibility of access to semantic and associative networks in autism, with no observed effect on phonological networks. Further study will be necessary to understand potential clinical implications of this finding.

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Clinical Trials Related to Inderal (Propranolol)

Bioavailability Study of Propranolol Under Fasting Conditions [Completed]
To compare the single-dose bioavailability of Propranolol 160 Mg ER capsules with Inderal-La

Bioavailability Study of Propranolol Under Fed Conditions [Completed]
To compare the single-dose bioavailability of Propranolol 160 Mg ER Capsules with Inderal-La

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft [Completed]

Food Study of Propranolol Hydrochloride Extended-Release Capsules 160 mg and Inderal® LA Capsules 160 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's propranolol hydrochloride extended-release 160 mg capsules to Wyeth's Inderal® LA 160 mg capsules following a single, oral 160 mg (1 x 160 mg) dose administered under fed conditions.

Fasting Study of Propranolol Hydrochloride Extended-Release Capsules 160 mg and Inderal® LA Capsules 160 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's propranolol hydrochloride extended-release 160 mg capsules to Wyeth's Inderal LA® 160 mg capsules following a single, oral 160 mg (1 x 160 mg) dose administration under fasting conditions.

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Reports of Suspected Inderal (Propranolol) Side Effects

Dizziness (9)Emotional Disorder (8)Migraine (8)Drug Hypersensitivity (8)Gastric Disorder (8)Drug Ineffective (7)Stress (7)Tremor (7)Memory Impairment (7)Weight Decreased (6)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 5 ratings/reviews, Inderal has an overall score of 7.60. The effectiveness score is 8 and the side effect score is 8.40. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Inderal review by 30 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   situational anxiety
Dosage & duration:   40mg daily as needed taken few times per month for the period of past 6 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I've used 40mg Inderal for situational anxiety a few times per month over the past 6 years. I found it to be very effective when taken 30min to 1hr prior to public speaking, large social gatherings, dates, and other anxiety provoking situations. It really helps decrease signs of nervousness resulting from the fight-or-flight response, such as increased heart rate, sweaty palms, and dry mouth.
Side effects:   none
Comments:   as above

 

Inderal review by 23 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Severe Performance Anxiety
Dosage & duration:   1.5 mg taken single dose a year for the period of 3 years
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Miracle drug for anyone who's deathly afraid of giving speeches or oral presentations. Eliminates the whole butterflies-in-the-stomach feeling, racing heart, sweaty palms and allows you to focus on what your doing and do it properly rather than worry about how nervous you are.
Side effects:   None.
Comments:   The doc first suggested that I take paxil every day for 3 wks before a speech and then get off it. I had to push her to prescribe me Inderal instead because I had researched all the drugs extensively and new what I was looking for. Never rely entirely on the judgement of doctors, always verify their advice and do your own research. It can save you time, money and alot of side effects. I take 3 small tablets and hour before a major speech or presentation (about once a year). I am thinking about using it for situational anxiety as another user suggested, I had never thought about it as I try to stay as far from drugs as possible and I only use them in extreme situations, but I have missed many networking opportunities because of my anxiety and I think that this drug would have helped. I have not experienced any side-effects. I don't think the drug has significantly risky long-term effects. I think the long-term negative effects of situational anxiety are far worse then the potential risks of inderal.

 

Inderal review by 31 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   hypertension
Dosage & duration:   40 mg taken once for the period of once
Other conditions:   asthma
Other drugs taken:   asthma maintenance meds
  
Reported Results
Benefits:   None
Side effects:   Nearly died after a severe asthmatic reaction to this drug. My OB prescribed this for me after Procardia XL caused me to have horrible headaches and nausea. DO NOT take this drug if you have asthma.
Comments:   Took one 40 mg pill at 8:45 in the morning. By 9:30 am I could not breathe and 911 was called. I lost consciousness before I was placed in the ambulance. I awoke in the ER and was told that I NEVER should have been prescribed this medication.

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Page last updated: 2014-12-09

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