INDERAL SUMMARY
Inderal (propranolol hydrochloride) is a synthetic beta-adrenergic receptor-blocking agent.
Inderal LA is indicated in the management of hypertension; it may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Inderal LA is not indicated in the management of hypertensive emergencies.
Inderal LA is indicated for the long-term management of patients with angina pectoris.
Inderal LA is indicated for the prophylaxis of common migraine headache. The efficacy of propranolol in the treatment of a migraine attack that has started has not been established, and propranolol is not indicated for such use.
Inderal LA is useful in the management of hypertrophic subaortic stenosis, especially for treatment of exertional or other stress-induced angina, palpitations, and syncope. Inderal LA also improves exercise performance. The effectiveness of propranolol hydrochloride in this disease appears to be due to a reduction of the elevated outflow pressure gradient, which is exacerbated by beta-receptor stimulation. Clinical improvement may be temporary.
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INDERAL NEWS HIGHLIGHTS
Published Studies Related to Inderal (Propranolol)
A comparison between the effect of oxytocin only and oxytocin plus propranolol on the labor (a double blind randomized trial). [2008.06]
OBJECTIVE: The comparison between the effect of oxytocin alone or in combination with propranolol [generic for Inderal] on labor... CONCLUSION: Propranolol may shorten the induction duration and labor and reduce the amount of necessary oxytocin.
Irbesartan plus low-dose propranolol versus low-dose propranolol alone in cirrhosis: a placebo-controlled, double-blind study. [2008.05]
OBJECTIVES: Angiotensin II receptor antagonists have been shown to moderately lower portal pressure in some patients with cirrhosis but may have adverse effects on kidney function. This study aimed at comparing the effects of a combined treatment using irbesartan plus propranolol [generic for Inderal] with propranolol monotherapy on portal pressure and kidney function in patients with cirrhosis... CONCLUSIONS: Combination treatment of propranolol plus irbesartan is well tolerated in cirrhotic patients when titrating the angiotensin II antagonist in a step-up manner, and it increases sodium excretion in patients with compensated or moderately decompensated cirrhosis. Addition of irbesartan has no effect on portal pressure.
Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. [2008.05]
The beta-adrenergic blocker propranolol [generic for Inderal] given within hours of a psychologically traumatic event reduces physiologic responses during subsequent mental imagery of the event. Here we tested the effect of propranolol given after the retrieval of memories of past traumatic events...
Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: A randomized controlled trial. [2008.03.28]
AIM: To study the hemodynamic effects of spironolactone with propranolol [generic for Inderal] vs propranolol alone in the secondary prophylaxis of variceal bleeding... CONCLUSION: Spironolactone with propranolol results in a better response with a greater reduction in hepatic venous pressure gradient in the secondary prophylaxis of variceal bleeding. A greater number of patients may be protected by this combination therapy than by propranolol alone. Hence, this combination may be recommended for secondary prophylaxis in patients with variceal bleeding.
Octreotide enhances portal pressure reduction induced by propranolol in cirrhosis: a randomized, controlled trial. [2007.10]
BACKGROUND: In vitro, octreotide potentiates vasoconstriction in isolated, preconstricted, mesenteric arterial vessels. In cirrhotic patients, portal pressure (HVPG) reduction induced by propranolol [generic for Inderal] is partly due to splanchnic vasoconstriction. AIM: To evaluate HVPG effects of octreotide administration in cirrhotic patients receiving long-term propranolol... CONCLUSIONS: Octreotide enhances HVPG reduction induced by propranolol in cirrhotic patients.
Clinical Trials Related to Inderal (Propranolol)
Bioavailability Study of Propranolol Under Fasting Conditions [Completed]
To compare the single-dose bioavailability of Propranolol 160 Mg ER capsules with Inderal-La
Bioavailability Study of Propranolol Under Fed Conditions [Completed]
To compare the single-dose bioavailability of Propranolol 160 Mg ER Capsules with Inderal-La
Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft [Completed]
Food Study of Propranolol Hydrochloride Extended-Release Capsules 160 mg and Inderal® LA Capsules 160 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's propranolol
hydrochloride extended-release 160 mg capsules to Wyeth's Inderal® LA 160 mg capsules
following a single, oral 160 mg (1 x 160 mg) dose administered under fed conditions.
Fasting Study of Propranolol Hydrochloride Extended-Release Capsules 160 mg and Inderal® LA Capsules 160 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's propranolol
hydrochloride extended-release 160 mg capsules to Wyeth's Inderal LA® 160 mg capsules
following a single, oral 160 mg (1 x 160 mg) dose administration under fasting conditions.
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INDERAL PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Inderal has an overall score of 9.50. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Inderal review by 30 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | situational anxiety |
| Dosage & duration: | | 40mg daily as needed taken few times per month for the period of past 6 years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | I've used 40mg Inderal for situational anxiety a few times per month over the past 6 years. I found it to be very effective when taken 30min to 1hr prior to public speaking, large social gatherings, dates, and other anxiety provoking situations. It really helps decrease signs of nervousness resulting from the fight-or-flight response, such as increased heart rate, sweaty palms, and dry mouth. |
| Side effects: | | none |
| Comments: | | as above |
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| | Inderal review by 21 year old male patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | situational anxiety |
| Dosage & duration: | | 40mg daily as needed taken few times per month for the period of 3 years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The major benefit of taking this medication was a decrease in the signs and symptoms of anxiety that I experience when in social situations. It prevents the elevation in heart rate that I normally get, as well as preventing dry mouth, sweaty palms, etc. As a result, I am much more able to focus on the task at hand. |
| Side effects: | | none |
| Comments: | | 40mg of Inderal generic taken as needed, 1/2 hour before anxiety provoking situations. |
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Page last updated: 2008-08-10
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