Inderal® (propranolol hydrochloride) is a synthetic beta-adrenergic receptor-blocking agent.
Inderal LA is indicated in the management of hypertension. It may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Inderal LA is not indicated in the management of hypertensive emergencies.
Angina Pectoris Due to Coronary Atherosclerosis
Inderal LA is indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris.
Inderal LA is indicated for the prophylaxis of common migraine headache. The efficacy of propranolol in the treatment of a migraine attack that has started has not been established, and propranolol is not indicated for such use.
Hypertrophic Subaortic Stenosis
Inderal LA improves NYHA functional class in symptomatic patients with hypertrophic subaortic stenosis.
Media Articles Related to Inderal (Propranolol)
It's time to consider propranolol as an anti-cancer drug, researchers say
Source: Cancer / Oncology News From Medical News Today [2016.10.14]
Propranolol, a beta-blocker commonly prescribed to treat irregular heart rates and other conditions, has significant anti-cancer properties, say researchers in a new clinical study published in...
Expression of Beta-Adrenergic Receptors Varies in Infantile Hemangioma
Source: Medscape Pathology & Lab Medicine Headlines [2016.10.21]
Infantile hemangiomas express different beta-adrenergic receptor subtypes during growth, involution, and response to propranolol treatment, researchers report.
Reuters Health Information
Published Studies Related to Inderal (Propranolol)
The study of antiarrhythmic medications in infancy (SAMIS): a multicenter,
randomized controlled trial comparing the efficacy and safety of digoxin versus
propranolol for prophylaxis of supraventricular tachycardia in infants. 
CONCLUSIONS: There was no difference in SVT recurrence in infants treated with
Status of propranolol for treatment of infantile hemangioma and description of a randomized clinical trial. [2011.10]
OBJECTIVES: Our primary objective was to review the current use of propranolol for treatment of infantile hemangioma (IH), specifically regarding 1) the age at initiation of therapy, 2) the method of initiation, 3) the use of other adjuvant therapy, 4) the duration of therapy and relapse rate, 5) the adverse events, and 6) the outcome. Our secondary objective was to describe a randomized, controlled, single-blinded trial comparing propranolol to prednisolone for treatment of IH... CONCLUSIONS: Propranolol is an attractive alternative to other treatments for IH. Despite apparent widespread use of this medication, the data are limited, and prospective studies are lacking for this indication. The relatively high rate of adverse effects supports the need for careful monitoring of patients on this therapy. Fastidious reporting of adverse events and objective evaluation of early and late outcomes are necessary to improve our understanding of the use of propranolol for this indication.
A randomized controlled trial of propranolol for infantile hemangiomas. [2011.08]
OBJECTIVE: Propranolol hydrochloride is a safe and effective medication for treating infantile hemangiomas (IHs), with decreases in IH volume, color, and elevation... CONCLUSION: Propranolol hydrochloride administered orally at 2 mg/kg per day reduced the volume, color, and elevation of focal and segmental IH in infants younger than 6 months and children up to 5 years of age.
Endoscopic variceal band ligation compared with propranolol for prophylaxis of first variceal bleeding. [2011.04]
Administration of nonselective beta-blockers in prophylaxis of first variceal bleeding is not suitable for all patients. Thus, we evaluated endoscopic variceal band ligation (EVBL) in primary prevention of bleeding in patients with cirrhosis and large esophageal varices... In conclusion, EVBL was an effective and safe alternative to propranolol in primary prophylaxis of bleeding in patients with large esophageal varices.
Effect of propranolol on word fluency in autism. [2011.03]
OBJECTIVE AND BACKGROUND: Autism is characterized by repetitive behaviors and impaired socialization and communication. Preliminary evidence showed possible language benefits in autism from the beta-adrenergic antagonist propranolol. Earlier studies in other populations suggested propranolol might benefit performance on tasks involving a search of semantic and associative networks under certain conditions. Therefore, we wished to determine whether this benefit of propranolol includes an effect on semantic fluency in autism... CONCLUSIONS: Results are consistent with a selective beneficial effect of propranolol on flexibility of access to semantic and associative networks in autism, with no observed effect on phonological networks. Further study will be necessary to understand potential clinical implications of this finding.
Clinical Trials Related to Inderal (Propranolol)
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease [Recruiting]
Propanolol is a beta blocker which has been found to inhibit the ability of epinephrine to
upregulate sickle red cell adhesion to laminin and endothelial cells in vitro. The purpose
of this pilot study is to administer one dose of propanolol to children with sickle cell
disease and to measure pre and post dose red cell adhesion. The hypothesis is that a single
dose of propanolol will decrease red cell adhesion to laminin and endothelial cells as
compared to baseline.
Efficacy of Propranolol Treatment to Prevent Melanoma Progression [Not yet recruiting]
Melanoma's incidence is increasing worldwide. The efforts made in melanoma screening led to
an earlier detection of the primary tumour and a better prognosis, but melanoma remains an
aggressive cancer when it comes to its metastatic stage. Three recent retrospective studies
compared groups of patients diagnosed with primary melanoma and treated with betablockers
for another indication to patients who never received betablockers. In these three studies,
the outcome of the disease is significantly better for people under betablocker treatment
with a decreased rate of recurrence and a better 5 years survival rate. Here we want to
investigate the efficacy and the tolerability of an adjuvant treatment with propranolol for
patients suffering from a primary melanoma with a high risk of recurrence.
Propranolol Treatment of Traumatic Memories (PTTM) [Recruiting]
This study will compare the responses of subjects with traumatic memories of varying
vintages to either propranolol or placebo in a double-blind setting. It is hypothesized that
those subjects who receive propranolol will experience less emotional distress when the
memory is subsequently reactivated and less spontaneous re-experiences.
Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD) [Recruiting]
Understanding what treatments may facilitate perioperative care of Veterans with
posttraumatic stress disorder (PTSD) is of great importance to the U. S. health care system.
Patients with PTSD are characterized by elevated central nervous system catecholamine
concentrations and exaggerated and prolonged adrenergic responses to stress stimuli. At
present, there are no data on the effects of perioperative beta blocker therapy in patients
with PTSD, despite the rising significance of PTSD in Veteran populations.
This prospective, double-blind study proposes to randomize 150 Veterans with PTSD scheduled
for orthopedic, thoracic or vascular surgery at the San Francisco VA Medical Center to
either a 14-day course of propranolol or placebo. This study will then follow these
Veterans for a one-year period to evaluate the effects of the intervention on Veterans'
The investigators hypothesize that patients with PTSD randomized to the propranolol group
will demonstrate a reduced incidence of perioperative and postoperative morbidity and
Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH) [Terminated]
This is a prospective randomized, double-blind study to compare the clinical efficacy of
infantile hemangioma treatment using propranolol with corticosteroids as compared to therapy
with corticosteroids and placebo. We hypothesize that a two-month treatment period with
propranolol plus corticosteroids is more effective at reducing infantile hemangioma size and
vascularity when compared to corticosteroids used without propranolol for the same time
Reports of Suspected Inderal (Propranolol) Side Effects
Emotional Disorder (8),
Drug Hypersensitivity (8),
Gastric Disorder (8),
Drug Ineffective (7),
Memory Impairment (7),
Weight Decreased (6), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 5 ratings/reviews, Inderal has an overall score of 7.60. The effectiveness score is 8 and the side effect score is 8.40. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Inderal review by 30 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || situational anxiety|
|Dosage & duration:|| || 40mg daily as needed taken few times per month for the period of past 6 years|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || I've used 40mg Inderal for situational anxiety a few times per month over the past 6 years. I found it to be very effective when taken 30min to 1hr prior to public speaking, large social gatherings, dates, and other anxiety provoking situations. It really helps decrease signs of nervousness resulting from the fight-or-flight response, such as increased heart rate, sweaty palms, and dry mouth.|
|Side effects:|| || none|
|Comments:|| || as above|
Inderal review by 23 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Severe Performance Anxiety|
|Dosage & duration:|| || 1.5 mg taken single dose a year for the period of 3 years|
|Other conditions:|| || None|
|Other drugs taken:|| || None|
|Benefits:|| || Miracle drug for anyone who's deathly afraid of giving speeches or oral presentations. Eliminates the whole butterflies-in-the-stomach feeling, racing heart, sweaty palms and allows you to focus on what your doing and do it properly rather than worry about how nervous you are.|
|Side effects:|| || None.|
|Comments:|| || The doc first suggested that I take paxil every day for 3 wks before a speech and then get off it. I had to push her to prescribe me Inderal instead because I had researched all the drugs extensively and new what I was looking for. Never rely entirely on the judgement of doctors, always verify their advice and do your own research. It can save you time, money and alot of side effects.
I take 3 small tablets and hour before a major speech or presentation (about once a year). I am thinking about using it for situational anxiety as another user suggested, I had never thought about it as I try to stay as far from drugs as possible and I only use them in extreme situations, but I have missed many networking opportunities because of my anxiety and I think that this drug would have helped. I have not experienced any side-effects. I don't think the drug has significantly risky long-term effects. I think the long-term negative effects of situational anxiety are far worse then the potential risks of inderal. |
Inderal review by 31 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Extremely Severe Side Effects|
|Condition / reason:|| || hypertension |
|Dosage & duration:|| || 40 mg taken once for the period of once|
|Other conditions:|| || asthma|
|Other drugs taken:|| || asthma maintenance meds |
|Benefits:|| || None|
|Side effects:|| || Nearly died after a severe asthmatic reaction to this drug. My OB prescribed this for me after Procardia XL caused me to have horrible headaches and nausea. DO NOT take this drug if you have asthma.
|Comments:|| || Took one 40 mg pill at 8:45 in the morning. By 9:30 am I could not breathe and 911 was called. I lost consciousness before I was placed in the ambulance. I awoke in the ER and was told that I NEVER should have been prescribed this medication.|
Page last updated: 2016-10-21