Indapamide (Indapamide) - Summary

INDAPAMIDE SUMMARY

INDAPAMIDE TABLETS USP

Indapamide is an oral antihypertensive/diuretic. Its molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety.

Indapamide tablets are indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs.

Indapamide tablets are also indicated for the treatment of salt and fluid retention associated with congestive heart failure.

See all Indapamide indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Indapamide

Large volume injection of 1-octanol as sample diluent in reversed phase liquid chromatography: application in bioanalysis for assaying of indapamide in whole blood. [2011.04.05]
Large volume injection of samples in strong diluents immiscible with the mobile phases used in reversed phase liquid chromatography (RPLC) has been recently introduced in practice. In the present work, the potential of the technique has been evaluated for bioanalytical applications...

Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease. [2010.12]
CONCLUSION: The treatment benefits of a routine administration of a fixed combination of perindopril-indapamide to patients with type 2 diabetes on cardiovascular and renal outcomes, and death, are consistent across all stages of CKD at baseline. Absolute risk reductions are larger in patients with CKD highlighting the importance of blood pressure-lowering in this population.

Management of high blood pressure in type 2 diabetes: perindopril/indapamide fixed-dose combination and the ADVANCE trial [corrected]. [2010.07]
IMPORTANCE OF THE FIELD: The increase in type 2 diabetes mellitus is associated to cardiovascular morbidity and mortality. This review focuses on the benefits of the fixed-dose combination of perindopril and indapamide on cardiovascular and renal end points in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation) trial...

Combination therapy with angiotensin-converting enzyme inhibitors and indapamide impairs glucose tolerance in Chinese hypertensive patients. [2010.04]
CONCLUSION: Fosinopril+indapamide combination therapy impaired GT in Chinese hypertensive patients, and fosinopril alone was able to reverse fosinopril+indapamide-induced GT impairment in part of these patients.

Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. [2009.12]
CONCLUSIONS: The combination of an ACEI and indapamide improved BP control, but attenuated the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. Such a combination may be best reserved for improved BP control rather than for metabolic protection in clinical hypertension.

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Clinical Trials Related to Indapamide

Comparison of Losartan Associated With Indapamide Versus Indapamide for Treatment of Hypertension [Not yet recruiting]

Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency [Not yet recruiting]
The purpose of this study is to evaluate the effects of indapamide SR 1. 5 mg on renal function, endothelial function, blood pressure variability by comparison with hydrochlorothiazide 25 mg, in patients with Mild to Moderate Renal Insufficiency and Hypertension.

A Comparison of Indapamide SR 1.5 mg With Hydrochlorothiazide 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate Hypertension and Type 2 Diabetes Mellitus [Recruiting]
The aim of this study is to evaluate the effects of indapamide SR 1. 5 mg on blood pressure, blood tests (glucose metabolism, lipids, minerals, and uric acid), cardiac function, endothelial and arterial function, by comparison with hydrochlorothiazide 25 mg, in patients with hypertension and type 2 diabetes mellitus. In order to achieve a better control of blood pressure in these patients, each diuretic treatments will be added to an ACE inhibitor (quinapril 10-40 mg/day). Therefore, eventually, the study will provide data on the comparison between combination indapamide SR 1. 5 mg + quinapril versus hydrochlorothiazide 25 mg + quinapril.

IDEAL Study: Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs [Recruiting]
The principal scientific objective of the trial is to identify the factors that are associated with differential blood pressure responses between drugs. This may allow investigators to produce new hypotheses on the pathophysiology of hypertension and on the mechanisms of drug action.

These factors can be of different types:

- Environmental factors (sodium or alcohol intake);

- Morphological (height, weight, body mass index, body surface area);

- Initial blood pressure;

- Electrocardiogram (ECG) parameters of left ventricular hypertrophy;

- Biological parameters as the activity level of the renin angiotensin aldosterone

system;

- Genetic polymorphisms.

Treatment for Calcium Phosphate Kidney Stone Disease [Recruiting]
The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

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Reports of Suspected Indapamide Side Effects

Hyponatraemia (46),  Hypokalaemia (26),  Vomiting (23),  Renal Failure Acute (22),  Disseminated Intravascular Coagulation (20),  Multi-Organ Failure (20),  Diarrhoea (20),  Nausea (19),  Cardiac Arrest (19),  Leukocytosis (17), more >>