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Inapsine (Droperidol) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

QT interval prolongation, torsade de pointes, cardiac arrest, and ventricular tachycardia have been reported in patients treated with INAPSINE. Some of these cases were associated with death. Some cases occurred in patients with no known risk factors, and some were associated with droperidol doses at or below recommended doses.

Physicians should be alert to palpitations, syncope, or other symptoms suggestive of episodes of irregular cardiac rhythm in patients taking INAPSINE and promptly evaluate such cases (see WARNINGS, Effects on Cardiac Conduction).

The most common somatic adverse reactions reported to occur with INAPSINE (droperidol) are mild to moderate hypotension and tachycardia, but these effects usually subside without treatment. If hypotension occurs and is severe or persists, the possibility of hypovolemia should be considered and managed with appropriate parenteral fluid therapy.

The most common behavioral adverse effects of INAPSINE (droperidol) include dysphoria, postoperative drowsiness, restlessness, hyperactivity and anxiety, which can either be the result of an inadequate dosage (lack of adequate treatment effect) or of an adverse drug reaction (part of the symptom complex of akathisia).

Care should be taken to search for extrapyramidal signs and symptoms (dystonia, akathisia, oculogyric crisis) to differentiate these different clinical conditions. When extrapyramidal symptoms are the cause, they can usually be controlled with anticholinergic agents.

Postoperative hallucinatory episodes (sometimes associated with transient periods of mental depression) have also been reported.

Other less common reported adverse reactions include anaphylaxis, dizziness, chills and/or shivering, laryn-gospasm, and bronchospasm.

Elevated blood pressure, with or without pre-existing hypertension, has been reported following administration of INAPSINE combined with SUBLIMAZE (fentanyl citrate) or other parenteral analgesics. This might be due to unexplained alterations in sympathetic activity following large doses: however, it is also frequently attributed to anesthetic or surgical stimulation during light anesthesia.



REPORTS OF SUSPECTED INAPSINE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Inapsine. The information is not vetted and should not be considered as verified clinical evidence.

Possible Inapsine side effects / adverse reactions in 44 year old female

Reported by a physician from United States on 2012-08-13

Patient: 44 year old female weighing 56.2 kg (123.7 pounds)

Reactions: Drug Hypersensitivity

Suspect drug(s):
Codeine

Compazine
    Indication: Nausea

Droperidol
    Dosage: unk

Ibuprofen
    Dosage: 200 mg, as needed

Imitrex
    Dosage: unk
    Indication: Migraine

Inapsine

Morphine Sulfate
    Indication: Pain

Motrin
    Dosage: unk

Reglan
    Dosage: unk

Risperdal
    Dosage: unk

Sumatriptan Succinate
    Dosage: unk

Toradol



See index of all Inapsine side effect reports >>

Drug label data at the top of this Page last updated: 2011-12-22

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