DRUG INTERACTIONS Drug Interactions
In a relatively limited experience, no untoward clinical manifestations have been observed in patients in which inamrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; metoprolol, propranolol; hydralazine, prazosin; isosorbide dinitrate, nitroglycerine; chlorthalidone, ethacrynic acid, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin; potassium supplements; insulin; diazepam.
One case report of excessive hypotension has been reported when inamrinone was used concurrently with disopyramide.
Until additional experience is available, concurrent administration with disopyramide should be undertaken with caution.
|
OVERDOSAGE
A death has been reported with a massive accidental overdose (840 mg over three hours by initial bolus and infusion) of inamrinone, although causal relation is uncertain. Diligence should be exercised during product preparation and administration.
Doses of inamrinone may produce hypotension because of its vasodilator effect. If this occurs, inamrinone administration should be reduced or discontinued. No specific antidote is known, but general measures for circulatory support should be taken.
In rats, the LD50 of inamrinone, as the lactate salt, was 102 mg/kg or 130 mg/kg intravenously in two different studies and 132 mg/kg orally (intragastrically); as a suspension in aqueous gum tragacanth the oral LD50 was 239 mg/kg.
|
