Inamrinone (Inamrinone) - Description

Rx ONLY.

Sterile Intravenous Solution

DESCRIPTION

Inamrinone Injection USP represents a new class of cardiac inotropic agents distinct from digitalis glycosides or catecholamines. Inamrinone lactate is designated chemically as 5-Amino[3,4'-bipyridin]-6(1 H)-one 2-hydroxypropanate and has the following structure:

Inamrinone is a pale yellow crystalline compound with a molecular weight of 187.20 and a molecular formula of C₁₀H₉N₃O. Each mole of lactic acid has a molecular weight of 90.08 and a empirical formula of C₃H₆O₃. The solubilities of inamrinone at pH’s 4.1, 6.0, and 8.0 are 25, 0.9, and 0.7 mg/mL, respectively.

Inamrinone injection is a clear yellow sterile solution available in 20 mL vials for intravenous administration. Each mL contains inamrinone lactate equivalent to 5 mg of inamrinone and 0.25 mg of sodium metabisulfite added as a preservative in Water for Injection. All dosages expressed in the package insert are expressed in terms of the base, inamrinone. The pH is adjusted to between 3.2 to 4.0 with lactic acid or sodium hydroxide. The total concentration of lactic acid can vary between 5 mg and 7.5 mg.