NEWS HIGHLIGHTSMedia Articles Related to Imodium (Loperamide)
Health Tip: When Infants Get Diarrhea (HealthDay)
Source: Y! Health News Search RSS Feed [2009.11.19]
HealthDay - (HealthDay News) -- Diarrhea in infants is common, often a
quick bout caused by a virus. But in some cases among young children,
diarrhea can quickly become dangerous, says the U.S. National Library of
Medicine.
Health Tip: When Infants Get Diarrhea
Source: MedicineNet Dehydration Specialty [2009.11.19]
Title: Health Tip: When Infants Get Diarrhea
Category: Health News
Created: 11/19/2009 8:10:00 AM
Last Editorial Review: 11/19/2009
Study Examines Campaign To Increase Use Of Zinc To Prevent Childhood Diarrhea
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.05]
Scientific American reports on a multiyear PLoS Medicine study, published on Monday, which "followed a nationwide public health campaign to increase zinc use for childhood diarrhea in Bangladesh." "A 10-day course of zinc tablets ...
Also In Global Health News: Breast Cancer In Developing World; Burkina Faso ITN Distribution; Diarrhea In People Over Age Five; Gates Q&A
Source: Tropical Diseases News From Medical News Today [2009.11.04]
Researchers Highlight 'Troubling Increase' In Breast Cancer In Developing Countries "International cancer specialists meet this week to plan an assault on a troubling increase of breast cancer in developing countries, where nearly two-thirds of women aren't diagnosed until it has spread through their bodies," the Associated Press reports.
New Research Reveals The Cause Of Common Chronic Diarrhea
Source: Endocrinology News From Medical News Today [2009.11.03]
A common type of chronic diarrhoea may be caused by a hormone deficiency, according to new research published in the November issue of Clinical Gastroenterology and Hepatology.
Published Studies Related to Imodium (Loperamide)
Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein. [2008.12]
BACKGROUND: Loperamide, a potent opioid, has been used as an in vivo probe to assess P-glycoprotein activity at the blood-brain barrier, because P-glycoprotein inhibition allows loperamide to cross the blood-brain barrier and exert its central opioid effects. In humans, studies with nonselective and moderately potent inhibitors resulted in mild opioid effects but were confounded by the concurrent inhibition of loperamide's metabolism. The authors studied the effect of the highly selective, potent P-glycoprotein inhibitor tariquidar on loperamide's central opioid effects... CONCLUSION: These results suggest that despite full inhibition of lymphocyte P-glycoprotein, the selective P-glycoprotein inhibitor tariquidar does not potentiate loperamide's opioid brain effects in humans.
Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain. [2008.12]
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects...
Potential Utility of Peripherally Applied Loperamide in Oral Chronic Graft-versus-host Disease Related Pain. [2008.10.24]
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects...
Azithromycin and loperamide are comparable to levofloxacin and loperamide for the treatment of traveler's diarrhea in United States military personnel in Turkey. [2007.08]
BACKGROUND: The recommended treatment for traveler's diarrhea is the combination of an appropriate antibiotic (usually a fluoroquinolone) and loperamide. Azithromycin compared favorably with fluoroquinolones in trials that did not include the use of loperamide, but combination therapy has not, to our knowledge, been studied to date... CONCLUSIONS: Single-dose treatment with azithromycin (1000 mg) and loperamide is as effective as single-dose treatment with levofloxacin (500 mg) and loperamide for noninflammatory diarrhea. Although nausea after dosing is uncommon, it is more frequently associated with azithromycin than with levofloxacin. Future studies should focus on determining whether lower doses of azithromycin would decrease the frequency of nausea and decrease treatment costs without affecting efficacy.
Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort. [2007.05]
CONCLUSIONS: LOP/SIM was well-tolerated and more efficacious than LOP alone, SIM alone, or placebo for acute nonspecific diarrhea and gas-related abdominal discomfort.
Clinical Trials Related to Imodium (Loperamide)
Rifaximin, Loperamide and the Combination to Treat Travelers' Diarrhea [Completed]
Most cases of travelers' diarrhea are caused by bacterial pathogens which respond slowly to
antibiotic treatment. The study was designed to determine the value of rapidly acting
loperamide (imodium) combined with curative dose of the poorly absorbed rifaximin in
travelers' diarreha treatment.
Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea [Completed]
In a previous study azithromycin proved as efficacious as levofloxacin in the treatment of
travelers' diarrhea in Mexico. Because the addition of loperamide to some antibiotics (e. g.,
trimethoprim-sulfamethoxazole and ofloxacin) has proven more efficacious than antibiotic
alone in the treatment of travelers' diarrhea, we decided to study the addition of loperamide
to azithromycin.
US adults with acute diarrhea in Guadalajara Mexico were randomized to receive azithromycin
in two different doses or loperamide plus azithromycin.
The duration of diarrhea was shorter (11 hours) in the combination-treated group compared to
the antibiotic-treated groups (34 hours). The percentage of subjects continuing to pass 6 or
more unformed stools in the first 24 hours was less (1. 7%) in the combination-treated group
than in the antibiotic-treated groups (20%).
We feel loperamide should routinely be added to an antibiotic to optimize treatment of
travelers' diarrhea.
Imodium Syrup Versus Imodium Tablets for Faecal Incontinence [Not yet recruiting]
Faecal incontinence (FI) is a debilitating and often neglected problem. It can be defined as
the loss of voluntary control of liquid or solid stool. It is estimated that 2-3% of western
adults suffer from FI with prevalence increasing with age, further to this up to 50% of
nursing home residents suffer too with it more common in females. Aetiology is often
multi-factoral, where obstetric anal sphincter injury is most common is females and
iatrogenic anal sphincter injury is most common in males.
Loperamide (imodium) is a constipating agent used as first choice pharmacological agent due
to its high efficacy. Trials have suggested it thickens stool consistency and may raise
resting anal sphincter pressure, associated with improved clinical function with a reduction
in bowel frequency and urgency, a reduction in incontinence and less need for pads.
Loperamide is well tolerated but has been known to cause side effects of abdominal pain and
distension, nausea and vomiting and constipation.
Imodium can be taken in two ways; as syrup (1mg/5mls) or tablets (2mg). There have been no
comparative studies. Side effects are mainly seen with the tablet form and so it is
hypothesized that the syrup form is better tolerated because it is more accurately titrated
to effect.
This is a NHS funded single blinded, randomised, cross-over study to assess the clinical
effects of Imodium, in tablet and syrup form, on patients presenting with faecal
incontinence. Each subject will act as their own control. Patients will be recruited through
out-patient visits for their FI, where they will be made aware of the trial. During the
trial they will be asked to fill out FI scoring questionnaires and quality of life scores.
Also they will undertake two assessments of anal physiology testing squeeze pressures,
sensation and compliance at baseline and at the end after three months.
A Comparison of Three Medications to Treat Diarrhea in Adults. [Recruiting]
Efficacy of Loperamide in Treating Patients for C. Difficile Colitis and Diarrheal Disease of Unknown Cause Associated With Antibiotic Therapy [Recruiting]
To determine whether symptomatic treatment of the diarrhea in CDAD reduces morbidity and
mortality of this serious nosocomial infection in patients who have antibiotic-associated
diarrhea. Both C. diff positive and negative patients will be included.
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