NEWS HIGHLIGHTSMedia Articles Related to Imodium (Loperamide)
Probiotics Linked To Lower Risk Of Diarrhea From Antibiotics
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2013.05.31]
Probiotic supplements can prevent or lower the risk of diarrhea caused by antibiotics, according to new research in The Cochrane Library. Scientists from the Cochrane Collaboration suggest that taking probiotics alongside antibiotics can prevent this troublesome side effect. Antibiotics interfere with the beneficial bacteria that live in the gut and permit other dangerous bacteria like C...
Encouraging Results In The Development Of An Oral Vaccine Against Diarrhea
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2013.05.27]
The University of Gothenburg Vaccine Research Institute (GUVAX) announces successful results in a placebo controlled phase I study of an oral, inactivated Escherichia coli diarrhea vaccine...
Antihistamine Meds May Raise Risk for Diarrheal Illness
Source: MedicineNet Clostridium Difficile Colitis Specialty [2013.04.01]
Title: Antihistamine Meds May Raise Risk for Diarrheal Illness
Category: Health News
Created: 3/29/2013 6:35:00 PM
Last Editorial Review: 4/1/2013 12:00:00 AM
Diarrhea
Source: MedicineNet Amyloidosis Specialty [2013.02.14]
Title: Diarrhea
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/14/2013 12:00:00 AM
Diarrhea and Digestive Distress Pictures Slideshow: Problem Foods to Avoid
Source: MedicineNet Gastroesophageal Reflux Disease (GERD) Specialty [2013.02.06]
Title: Diarrhea and Digestive Distress Pictures Slideshow: Problem Foods to Avoid
Category: Slideshows
Created: 2/6/2013 12:00:00 AM
Last Editorial Review: 2/6/2013 12:00:00 AM
Published Studies Related to Imodium (Loperamide)
Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. [2010.02]
CONCLUSIONS: Racecadotril is more effective than loperamide-probably due to drug interaction with loperamide-and it is not related to pharmacogenetic susceptibility. Racecadotril is also more cost effective than loperamide.
Prospective randomized double-blind trial of racecadotril compared with
loperamide in elderly people with gastroenteritis living in nursing homes. [2010]
CONCLUSIONS: Racecadotril is more effective than loperamide-probably due to drug
Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein. [2008.12]
BACKGROUND: Loperamide, a potent opioid, has been used as an in vivo probe to assess P-glycoprotein activity at the blood-brain barrier, because P-glycoprotein inhibition allows loperamide to cross the blood-brain barrier and exert its central opioid effects. In humans, studies with nonselective and moderately potent inhibitors resulted in mild opioid effects but were confounded by the concurrent inhibition of loperamide's metabolism. The authors studied the effect of the highly selective, potent P-glycoprotein inhibitor tariquidar on loperamide's central opioid effects... CONCLUSION: These results suggest that despite full inhibition of lymphocyte P-glycoprotein, the selective P-glycoprotein inhibitor tariquidar does not potentiate loperamide's opioid brain effects in humans.
Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain. [2008.12]
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects...
Potential Utility of Peripherally Applied Loperamide in Oral Chronic Graft-versus-host Disease Related Pain. [2008.10.24]
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects...
Clinical Trials Related to Imodium (Loperamide)
Imodium Syrup Versus Imodium Tablets for Faecal Incontinence [Not yet recruiting]
Faecal incontinence (FI) is a debilitating and often neglected problem. It can be defined as
the loss of voluntary control of liquid or solid stool. It is estimated that 2-3% of western
adults suffer from FI with prevalence increasing with age, further to this up to 50% of
nursing home residents suffer too with it more common in females. Aetiology is often
multi-factoral, where obstetric anal sphincter injury is most common is females and
iatrogenic anal sphincter injury is most common in males.
Loperamide (imodium) is a constipating agent used as first choice pharmacological agent due
to its high efficacy. Trials have suggested it thickens stool consistency and may raise
resting anal sphincter pressure, associated with improved clinical function with a reduction
in bowel frequency and urgency, a reduction in incontinence and less need for pads.
Loperamide is well tolerated but has been known to cause side effects of abdominal pain and
distension, nausea and vomiting and constipation.
Imodium can be taken in two ways; as syrup (1mg/5mls) or tablets (2mg). There have been no
comparative studies. Side effects are mainly seen with the tablet form and so it is
hypothesized that the syrup form is better tolerated because it is more accurately titrated
to effect.
This is a NHS funded single blinded, randomised, cross-over study to assess the clinical
effects of Imodium, in tablet and syrup form, on patients presenting with faecal
incontinence. Each subject will act as their own control. Patients will be recruited through
out-patient visits for their FI, where they will be made aware of the trial. During the
trial they will be asked to fill out FI scoring questionnaires and quality of life scores.
Also they will undertake two assessments of anal physiology testing squeeze pressures,
sensation and compliance at baseline and at the end after three months.
Efficacy of Loperamide in Treating Patients for C. Difficile Colitis and Diarrheal Disease of Unknown Cause Associated With Antibiotic Therapy [Recruiting]
To determine whether symptomatic treatment of the diarrhea in CDAD reduces morbidity and
mortality of this serious nosocomial infection in patients who have antibiotic-associated
diarrhea. Both C. diff positive and negative patients will be included.
Rifaximin, Loperamide and the Combination to Treat Travelers' Diarrhea [Completed]
Most cases of travelers' diarrhea are caused by bacterial pathogens which respond slowly to
antibiotic treatment. The study was designed to determine the value of rapidly acting
loperamide (imodium) combined with curative dose of the poorly absorbed rifaximin in
travelers' diarreha treatment.
Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea [Completed]
In a previous study azithromycin proved as efficacious as levofloxacin in the treatment of
travelers' diarrhea in Mexico. Because the addition of loperamide to some antibiotics (e. g.,
trimethoprim-sulfamethoxazole and ofloxacin) has proven more efficacious than antibiotic
alone in the treatment of travelers' diarrhea, we decided to study the addition of loperamide
to azithromycin.
US adults with acute diarrhea in Guadalajara Mexico were randomized to receive azithromycin
in two different doses or loperamide plus azithromycin.
The duration of diarrhea was shorter (11 hours) in the combination-treated group compared to
the antibiotic-treated groups (34 hours). The percentage of subjects continuing to pass 6 or
more unformed stools in the first 24 hours was less (1. 7%) in the combination-treated group
than in the antibiotic-treated groups (20%).
We feel loperamide should routinely be added to an antibiotic to optimize treatment of
travelers' diarrhea.
A Comparison of Three Medications to Treat Diarrhea in Adults. [Recruiting]
Reports of Suspected Imodium (Loperamide) Side Effects
Diarrhoea (12),
Intestinal Obstruction (11),
Abdominal Pain (9),
Vomiting (8),
Pulmonary Embolism (7),
Intentional Drug Misuse (7),
Intestinal Ischaemia (6),
Nausea (6),
Lymphadenopathy (5),
Pruritus (5), more >>
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