DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Imodium (Loperamide Hydrochloride) - Summary

 
 



IMODIUM SUMMARY

IMODIUM® (loperamide hydrochloride), 4-(p-chlorophenyl)-4-hydroxy-N, N-dimethyl-(alpha),(alpha)-diphenyl-1-piperidinebutyramide monohydrochloride, is a synthetic antidiarrheal for oral use.

IMODIUM® (loperamide hydrochloride) is indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. IMODIUM® is also indicated for reducing the volume of discharge from ileostomies.


See all Imodium indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Imodium (Loperamide)

IBS-D (Irritable Bowel Syndrome with Diarrhea)
Source: MedicineNet Constipation Specialty [2017.09.22]
Title: IBS-D (Irritable Bowel Syndrome with Diarrhea)
Category: Diseases and Conditions
Created: 8/10/2016 12:00:00 AM
Last Editorial Review: 9/22/2017 12:00:00 AM

Diarrhea
Source: MedicineNet Addison Disease Specialty [2017.03.21]
Title: Diarrhea
Category: Symptoms and Signs
Created: 10/13/2003 12:00:00 AM
Last Editorial Review: 3/21/2017 12:00:00 AM

Travelers' Diarrhea
Source: MedicineNet attapulgite Specialty [2016.03.16]
Title: Travelers' Diarrhea
Category: Diseases and Conditions
Created: 4/3/1999 12:00:00 AM
Last Editorial Review: 3/16/2016 12:00:00 AM

New Meds OK'd for Hard-to-Treat IBS With Diarrhea
Source: MedicineNet alosetron Specialty [2015.05.29]
Title: New Meds OK'd for Hard-to-Treat IBS With Diarrhea
Category: Health News
Created: 5/29/2015 12:00:00 AM
Last Editorial Review: 5/29/2015 12:00:00 AM

A 37-Year-Old Woman With Bloating and Itchy Vesicles
Source: Medscape Allergy & Clinical Immunology Headlines [2017.09.29]
A 37-year-old woman presents with diarrhea and bloating over the past few years. She also reports itchy vesicles around the extensor surfaces of her arms and legs. What condition is responsible?
Osmosis

more news >>

Published Studies Related to Imodium (Loperamide)

Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. [2010.02]
CONCLUSIONS: Racecadotril is more effective than loperamide-probably due to drug interaction with loperamide-and it is not related to pharmacogenetic susceptibility. Racecadotril is also more cost effective than loperamide.

Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. [2010]
CONCLUSIONS: Racecadotril is more effective than loperamide-probably due to drug

Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein. [2008.12]
BACKGROUND: Loperamide, a potent opioid, has been used as an in vivo probe to assess P-glycoprotein activity at the blood-brain barrier, because P-glycoprotein inhibition allows loperamide to cross the blood-brain barrier and exert its central opioid effects. In humans, studies with nonselective and moderately potent inhibitors resulted in mild opioid effects but were confounded by the concurrent inhibition of loperamide's metabolism. The authors studied the effect of the highly selective, potent P-glycoprotein inhibitor tariquidar on loperamide's central opioid effects... CONCLUSION: These results suggest that despite full inhibition of lymphocyte P-glycoprotein, the selective P-glycoprotein inhibitor tariquidar does not potentiate loperamide's opioid brain effects in humans.

Potential utility of peripherally applied loperamide in oral chronic graft-versus-host disease related pain. [2008.12]
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects...

Potential Utility of Peripherally Applied Loperamide in Oral Chronic Graft-versus-host Disease Related Pain. [2008.10.24]
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects...

more studies >>

Clinical Trials Related to Imodium (Loperamide)

Loperamide Grapefruit Juice Interaction PK Trial [Completed]
A 10-day study to determine if grapefruit juice has any effect on how loperamide (Imodium) affects the body and how the body affects loperamide.

Controlling Anal Incontinence by Performing Anal Exercises With Biofeedback or Loperamide (CAPABLe) [Recruiting]
The goals of this trial are to compare the use of loperamide to oral placebo and to compare the use of anal sphincter exercise training with biofeedback to usual care (educational pamphlet) in the treatment of women suffering from fecal incontinence (FI). We will test the following null hypotheses: 1. there is no difference in outcomes between women randomized to loperamide and women randomized to oral placebo for treatment of FI; 2. there is no difference in outcomes between women randomized to anal sphincter exercises with biofeedback and women randomized to usual care (educational pamphlet) for FI treatment; 3. there is no difference between women randomized to both treatments together and women randomized to either FI treatment alone; and 4. there is no correlation between anal manometry measurements and digital anal squeeze strength or measures of FI severity and bother. A supplemental study, Stool Metabolome and Microbiome in Women with Fecal Incontinence in CAPABLe, will evaluate the stool metabolome and microbiome in women with fecal incontinence and unaffected age matched controls.

Efficacy of Loperamide in Treating Patients for C. Difficile Colitis and Diarrheal Disease of Unknown Cause Associated With Antibiotic Therapy [Recruiting]
To determine whether symptomatic treatment of the diarrhea in CDAD reduces morbidity and mortality of this serious nosocomial infection in patients who have antibiotic-associated diarrhea. Both C. diff positive and negative patients will be included.

Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea [Completed]
In a previous study azithromycin proved as efficacious as levofloxacin in the treatment of travelers' diarrhea in Mexico. Because the addition of loperamide to some antibiotics (e. g., trimethoprim-sulfamethoxazole and ofloxacin) has proven more efficacious than antibiotic alone in the treatment of travelers' diarrhea, we decided to study the addition of loperamide to azithromycin. US adults with acute diarrhea in Guadalajara Mexico were randomized to receive azithromycin in two different doses or loperamide plus azithromycin. The duration of diarrhea was shorter (11 hours) in the combination-treated group compared to the antibiotic-treated groups (34 hours). The percentage of subjects continuing to pass 6 or more unformed stools in the first 24 hours was less (1. 7%) in the combination-treated group than in the antibiotic-treated groups (20%). We feel loperamide should routinely be added to an antibiotic to optimize treatment of travelers' diarrhea.

Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and Flatulence [Completed]
The purpose of this study is to evaluate the efficacy and safety of combined loperamide hydrochloride and simethicone compared to loperamide hydrochloride monotherapy in treating acute diarrhea associated with abdominal discomfort caused by gastrointestinal gas accumulation.

more trials >>

Reports of Suspected Imodium (Loperamide) Side Effects

Diarrhoea (12)Intestinal Obstruction (11)Abdominal Pain (9)Vomiting (8)Pulmonary Embolism (7)Intentional Drug Misuse (7)Intestinal Ischaemia (6)Nausea (6)Lymphadenopathy (5)Pruritus (5)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Imodium has an overall score of 7.67. The effectiveness score is 7.33 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
 

Imodium review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Diarrhoea/IBS
Dosage & duration:   100mg taken as per necessity for the period of still taking it
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Whenever I had a diarrhoea attack I could take two pills of the drug and the attacks diminished in numer and intensity, not blocking my intestinal activity afterwards
Side effects:   I did not have any side effects
Comments:   After the first attack I take two pills of Imodium, then uno more pills per subsequent attack, with a maximum of 8 pills per day. If no more attacks happen in the next eight hours after the last diarrhoea episode, there is no need to take more pills

 

Imodium review by 52 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Diarrhea
Dosage & duration:   2, then 1 after each bowel movement (dosage frequency: 3 times) for the period of 1 day
Other conditions:   None
Other drugs taken:   Anti-nausea introvenous
  
Reported Results
Benefits:   Diarrhea lessened after about 8 hours, but not until after another 2 severe occurences. Had hoped for quicker, more effective response.
Side effects:   No side effects.
Comments:   Had severe intestinal irritation afer eating a meal out with Southwestern sausages. Went to emergency room. Was administered Iomodium orally in emergency room and took it later on my own.

 

Imodium review by 52 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Diarrhea
Dosage & duration:   2, then 1 after each bowel movement (dosage frequency: 3 times) for the period of 1 day
Other conditions:   None
Other drugs taken:   Anti-nausea introvenous
  
Reported Results
Benefits:   Diarrhea lessened after about 8 hours, but not until after another 2 severe occurences. Had hoped for quicker, more effective response.
Side effects:   No side effects.
Comments:   Had severe intestinal irritation afer eating a meal out with Southwestern sausages. Went to emergency room. Was administered Iomodium orally in emergency room and took it later on my own.

See all Imodium reviews / ratings >>

Page last updated: 2017-09-29

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017