Imitrex (Sumatriptan Succinate) - Summary

IMITREX SUMMARY

IMITREX Tablets contain sumatriptan (as the succinate), a selective 5-hydroxytryptamine₁ receptor subtype agonist.

IMITREX Tablets are indicated for the acute treatment of migraine attacks with or without aura in adults.

IMITREX Tablets are not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of IMITREX Tablets have not been established for cluster headache, which is present in an older, predominantly male population.

See all Imitrex indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Imitrex (Sumatriptan)

Reduced efficacy of sumatriptan in migraine with aura vs without aura. [2015]
migraine with aura compared with migraine without aura... CONCLUSION: This post hoc analysis of pooled data from multiple randomized trials

Sumatriptan iontophoretic transdermal system for the acute treatment of migraine. [2014]
SUMMARY We will describe the pharmacokinetic profile, clinical efficacy and safety data of the sumatriptan iontophoretic transdermal system (Zecuity®, NuPathe Inc., PA, USA), recently approved for the acute treatment of migraine with or without aura in adults, by the US FDA.This sumatriptan transdermal system may be a good choice for migraineurs with severe nausea or vomiting, those with intolerable triptan-related adverse events and/or those not responding optimally to oral medications.

Sumatriptan plus naproxen for acute migraine attacks in adults. [2013]
CONCLUSIONS: Combination treatment was effective in the acute treatment

A sumatriptan iontophoretic transdermal system for the acute treatment of migraine. [2012]
treatment of migraine... CONCLUSIONS: The sumatriptan iontophoretic transdermal system is effective and

Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults. [2012]
CONCLUSIONS: Subcutaneous sumatriptan is effective as an abortive

more studies >>

Clinical Trials Related to Imitrex (Sumatriptan)

A Study to Determine the Effect of Sumatriptan and Naproxen Sodium Combination Tablet, Sumatriptan Tablet, and Naproxen Sodium Tablet on Blood Pressure When Treating Migraine Headaches That Occur During a 6-month Period [Completed]
The purpose of this study is to test the effect on blood pressure of sumatriptan and naproxen sodium combination tablets, tablets containing only sumatriptan, and tablets containing only naproxen sodium when these drugs are taken to treat migraine headaches that occur during a 6-month period.

Bioavailability Study to Compare OPTINOSE SUMATRIPTAN With IMITREX� in Healthy Subjects [Completed]
The purpose of this study is:

- To compare the single-dose pharmacokinetics (PK) of intranasal administration of 20 mg

OPTINOSE SUMATRIPTAN with 20 mg IMITREX® (sumatriptan) Nasal Spray, 100 mg IMITREX® (sumatriptan) Oral Tablet, and 6 mg IMITREX® (sumatriptan) Subcutaneous Injection, in healthy subjects.

- To estimate the relative bioavailability of single-dose intranasal administration of 20

mg OPTINOSE SUMATRIPTAN, 20 mg IMITREX® (sumatriptan) Nasal Spray, and 100 mg IMITREX® (sumatriptan) Oral Tablet compared to a single-dose of 6 mg IMITREX® (sumatriptan) Subcutaneous Injection, in healthy subjects.

The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache [Recruiting]
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a phosphodiesterase inhibitor (cilostazol). If the headache responds to sumatriptan, the model can be used to test new drug candidates.

The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache [Recruiting]
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a long lasting Nitrogen Oxide (NO) donor. If the headache responds to sumatriptan, the model can be used to test new drug candidates.

Sumatriptan and Naratriptan Pregnancy Registry [Completed]
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However, the peak prevalence of migraine is in women of childbearing age. This, coupled with the sporadic nature of migraine attacks and high rates of unplanned pregnancies, makes unintentional exposure to anti-migraine medications during pregnancy likely. Prior to an anti-migraine medication being marketed there are few data available on drug safety in pregnancy: data from animal models may not translate directly to humans and pregnant women are routinely excluded from clinical trials. The Sumatriptan Pregnancy Registry was established by GlaxoSmithKline (GSK) in 1996 to monitor the safety of sumatriptan during pregnancy. It was combined with the Naratriptan Pregnancy Registry in 2001 and data collection on the sumatriptan-naproxen combination (Treximet) began in 2008.

more trials >>

Reports of Suspected Imitrex (Sumatriptan) Side Effects

Drug Ineffective (87),  Migraine (32),  Headache (31),  Nausea (24),  Vomiting (20),  Fatigue (15),  Chest Pain (15),  Muscle Spasms (15),  Product Quality Issue (15),  Injection Site Pain (13), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Imitrex review by 55 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Migraine headaches
Dosage & duration:		100 mg taken as needed for the period of I have been taking as needed for 6 years
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		Complete relief from pain with one 100 mg tablet. Alleviated the sensitivity to light, noise and nausea. Symptoms would abate in one to two hours.
Side effects:		A little "fuzzy headed" until it took effect.
Comments:		This is taken as needed. It works best to take at the onset of the migraine and not to wait to see if will go away.

Imitrex review by 44 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		migraine
Dosage & duration:		100mg taken 3-6/month for the period of 5 years
Other conditions:		peri-menopause
Other drugs taken:		nsaids
		Reported Results
Benefits:		the only complete relief from one sided headache and nausea
Side effects:		slight fatigue occasional tachycardia
Comments:		I was prescribed 100mg dosage pills, which are about the same price ($15/pill) as 50 mg. Taking a whole pill gave me relief but also a light headed sensation and odd heartbeat. I bit the pills in two to take approx. 50mg. Gradually my system became inured to it's effects and I had to take the whole pill, also occasionally it just doesn't work anymore. I have long lasting recurring headaches and have always been worried about overuse and rebound headaches, but so far, so good.

Imitrex review by 19 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		Migraine
Dosage & duration:		10mg taken as needed for the period of once
Other conditions:		Other allergies
Other drugs taken:		Birth Control
		Reported Results
Benefits:		none
Side effects:		Within 30 minutes of taking my first dose of imitrex (on Christmas eve) when I felt the onset of my migraine, I began to feel a heavy, cramping feeling in my muscles like I had slept the wrong way. Then my back began to ache and my joints began to cramp up and throb. My chest felt heavy and I had trouble breathing and remembering to breath. My throat and neck hurt so back and it felt like i had strained it or pulled a muscle. My train of thought was messed up and I could not concentrate or form full comprehensive sentences. There was nothing I could do so I just waited it out, towards the end (nearly 4 hours later) I tried eating and my salivary glands went crazy! I felt like I was drinking and eating scalding hot food, it was crazy! I will NEVER take that again. I called my doctor and she moved me immediately to MAXALT, IT IS GREAT, I LOVE IT. I have other allergies so it is no surprise to me that I had a reaction, but the severity was shocking. Don't settle for a medication that makes you feel only half good.
Comments:		Took when then on set of a migraine was felt.