Imitrex (Sumatriptan Succinate) - Summary

IMITREX SUMMARY

IMITREX®
(sumatriptan succinate)
Tablets

IMITREX Tablets contain sumatriptan (as the succinate), a selective 5-hydroxytryptamine₁ receptor subtype agonist.

IMITREX Tablets are indicated for the acute treatment of migraine attacks with or without aura in adults.

IMITREX Tablets are not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of IMITREX Tablets have not been established for cluster headache, which is present in an older, predominantly male population.

See all Imitrex indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Imitrex (Sumatriptan)

Skin Patch For Migraines Receives FDA Approval
Source: Headache / Migraine News From Medical News Today [2013.01.20]
The FDA has approved Zecuity (sumatriptan iontophoretic transdermal system) for the treatment of acute migraine in adults with or without aura. Zecuity is a battery-powered skin patch that delivers sumatriptan through the patient's skin - it is a single-use medication. Sumatriptan is the most extensively prescribed migraine drug. According to NuPathe Inc...

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Published Studies Related to Imitrex (Sumatriptan)

A sumatriptan iontophoretic transdermal system for the acute treatment of migraine. [2012]
treatment of migraine... CONCLUSIONS: The sumatriptan iontophoretic transdermal system is effective and

Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults. [2012]
CONCLUSIONS: Subcutaneous sumatriptan is effective as an abortive

Sumatriptan-naproxen sodium for menstrual migraine and dysmenorrhea: satisfaction, productivity, and functional disability outcomes. [2011.05]
OBJECTIVE: To evaluate the impact of a sumatriptan/naproxen sodium combination tablet on patient satisfaction, productivity, and functional disability in menstrual migraine treated during the mild pain phase of a single menstrual migraine attack associated with dysmenorrhea. BACKGROUND: Menstrual migraineurs with dysmenorrhea represent a unique patient population not previously studied. When health outcomes end points are analyzed alongside traditional efficacy end points in migraine studies, a more comprehensive and robust understanding of the many factors that may influence patients' choice of and adherence to pharmacological treatments for migraine is observed... CONCLUSION: A fixed-dose combination tablet containing sumatriptan and naproxen sodium significantly improved patient satisfaction, productivity, and restoration of normal functioning in menstrual migraineurs with dysmenorrhea. (c) 2011 American Headache Society.

Efficacy and tolerability of rizatriptan for the treatment of acute migraine in sumatriptan non-responders. [2011.05]
OBJECTIVE: The study was carried out to assess the efficacy and tolerability of rizatriptan orally disintegrating tablet (ODT) for treating acute migraine in patients who are non-responders to sumatriptan. BACKGROUND: Many migraineurs report dissatisfaction with sumatriptan efficacy. It is unclear whether sumatriptan 100 mg non-responders will respond to other triptans... CONCLUSION: Rizatriptan 10-mg ODT was superior to placebo at providing two-hour pain relief and two-hour pain freedom in the treatment of acute migraine in those who do not respond to sumatriptan 100 mg. Rizatriptan was generally well tolerated in this population.

Serotonin function in pathological gambling: blunted growth hormone response to sumatriptan. [2010.12]
Pathological gambling is a disruptive behaviour and an important public health concern that is classified as an impulse control disorder, and is also conceptualized as a prototype of 'behavioural addiction'. Its phenomenology cannot be reduced to a single neurobiological dysfunction; instead, it has been conceived as a complex chain of events in which the serotonergic system (5-HT) has often been suggested as one of the most prominent involved...

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Clinical Trials Related to Imitrex (Sumatriptan)

Food Study of Sumatriptan Succinate Tablets 100 mg to Imitrex® Tablets 100 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's sumatriptan succinate 100 mg tablets to GSK's Imitrex® 100 mg tablets following a single, oral 100 mg (1 x 100 mg) dose administered under fed conditions.

Fasting Study of Sumatriptan Succinate Tablets 100 mg to Imitrex® Tablets 100 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's sumatriptan succinate 100 mg tablets to GSK's Imitrex® 100 mg tablets following a single, oral 100 mg (1 x 100 mg) dose administration under fasting conditions.

Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department [Completed]
ED patients with acute migraine will be randomized to either prochlorperazine and Bendaryl OR imitrex. VAS for pain will be monitored, along with side effects. Primary outcome measure is improvement in pain scales between the groups.

Efficacy and Safety of 20 mg Sumatriptan Powder Delivered Intranasally With the Bi-directional Device Compared With 100 mg Sumatriptan Tablets in Adults With Acute Migraine With or Without [Recruiting]
This study is being conducted to determine if OPTINOSE SUMATRIPTAN delivered nasally (through the nose) using the OPTINOSE SUMATRIPTAN DEVICE can reduce the pain associated with migraine headaches in 30 minutes after use.

Sumatriptan and Naratriptan Pregnancy Registry [Recruiting]
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However, the peak prevalence of migraine is in women of childbearing age. This, coupled with the sporadic nature of migraine attacks and high rates of unplanned pregnancies, makes unintentional exposure to anti-migraine medications during pregnancy likely. Prior to an anti-migraine medication being marketed there are few data available on drug safety in pregnancy: data from animal models may not translate directly to humans and pregnant women are routinely excluded from clinical trials. The Sumatriptan Pregnancy Registry was established by GlaxoSmithKline (GSK) in 1996 to monitor the safety of sumatriptan during pregnancy. It was combined with the Naratriptan Pregnancy Registry in 2001 and data collection on the sumatriptan-naproxen combination (Treximet) began in 2008.

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Reports of Suspected Imitrex (Sumatriptan) Side Effects

Drug Ineffective (87),  Migraine (32),  Headache (31),  Nausea (24),  Vomiting (20),  Fatigue (15),  Chest Pain (15),  Muscle Spasms (15),  Product Quality Issue (15),  Injection Site Pain (13), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Imitrex review by 55 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Migraine headaches
Dosage & duration:		100 mg taken as needed for the period of I have been taking as needed for 6 years
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		Complete relief from pain with one 100 mg tablet. Alleviated the sensitivity to light, noise and nausea. Symptoms would abate in one to two hours.
Side effects:		A little "fuzzy headed" until it took effect.
Comments:		This is taken as needed. It works best to take at the onset of the migraine and not to wait to see if will go away.

Imitrex review by 44 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		migraine
Dosage & duration:		100mg taken 3-6/month for the period of 5 years
Other conditions:		peri-menopause
Other drugs taken:		nsaids
		Reported Results
Benefits:		the only complete relief from one sided headache and nausea
Side effects:		slight fatigue occasional tachycardia
Comments:		I was prescribed 100mg dosage pills, which are about the same price ($15/pill) as 50 mg. Taking a whole pill gave me relief but also a light headed sensation and odd heartbeat. I bit the pills in two to take approx. 50mg. Gradually my system became inured to it's effects and I had to take the whole pill, also occasionally it just doesn't work anymore. I have long lasting recurring headaches and have always been worried about overuse and rebound headaches, but so far, so good.

Imitrex review by 19 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		Migraine
Dosage & duration:		10mg taken as needed for the period of once
Other conditions:		Other allergies
Other drugs taken:		Birth Control
		Reported Results
Benefits:		none
Side effects:		Within 30 minutes of taking my first dose of imitrex (on Christmas eve) when I felt the onset of my migraine, I began to feel a heavy, cramping feeling in my muscles like I had slept the wrong way. Then my back began to ache and my joints began to cramp up and throb. My chest felt heavy and I had trouble breathing and remembering to breath. My throat and neck hurt so back and it felt like i had strained it or pulled a muscle. My train of thought was messed up and I could not concentrate or form full comprehensive sentences. There was nothing I could do so I just waited it out, towards the end (nearly 4 hours later) I tried eating and my salivary glands went crazy! I felt like I was drinking and eating scalding hot food, it was crazy! I will NEVER take that again. I called my doctor and she moved me immediately to MAXALT, IT IS GREAT, I LOVE IT. I have other allergies so it is no surprise to me that I had a reaction, but the severity was shocking. Don't settle for a medication that makes you feel only half good.
Comments:		Took when then on set of a migraine was felt.