Imdur (Isosorbide Mononitrate) - Summary

IMDUR SUMMARY

IMDUR^®
(isosorbide mononitrate)
Extended Release Tablets

Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. IMDUR^® Tablets contain 30 mg, 60 mg, or 120 mg of isosorbide mononitrate in an extended-release formulation.

IMDUR Tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.

IMDUR NEWS HIGHLIGHTS

Published Studies Related to Imdur (Isosorbide Mononitrate)

Outpatient cervical ripening with nitric oxide donor isosorbide mononitrate prior to induction of labor. [2008.04]

Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. [2007.09]

Nitric oxide donor isosorbide mononitrate for pre-induction cervical ripening at 41 weeks' gestation: A randomized controlled trial. [2007.08]

Pentaerythrityl Tetranitrate and Nitroglycerin, but not Isosorbide Mononitrate, Prevent Endothelial Dysfunction Induced by Ischemia and Reperfusion. [2007.07.19]

Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism. [2007.03.27]

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Clinical Trials Related to Imdur (Isosorbide Mononitrate)

Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients [Recruiting]

Trial of Cervical Ripening and Labor Induction Using Misoprostol With or Without Intravaginal Isosorbide Mononitrate [Active, not recruiting]

Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3 [Recruiting]

Secondary Prophylaxis After Variceal Bleeding in Non-Responders [Completed]

Treatment of Orthostatic Intolerance [Recruiting]

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