Published Studies Related to Imdur (Isosorbide Mononitrate)
Intravaginal administration of isosorbide mononitrate and misoprostol for cervical ripening and induction of labour: a randomized controlled trial. [2011.07]
BACKGROUND: Labor induction in the presence of unfavorable cervix is a common indication for the use of prostaglandins. However, in the last years, there has been a considerable interest in the use of nitrous oxide donors for cervical ripening and labor induction. OBJECTIVE: To evaluate the efficacy and safety of intravaginal administration of NOD isosorbide mononitrate (IMN) plus misoprostol versus misoprostol alone for cervical ripening and induction of labor. SETTING: Department of Obstetrics and Gynecology, Woman's Health Center, Assiut University... CONCLUSIONS: Using a combination of IMN and misoprostol is more efficient than misoprostol alone in terms of fast cervical ripening and shortening of induction-labour interval.
Comparison of isosorbide mononitrate and misoprostol for cervical ripening in termination of pregnancy between 8 and 12 weeks: a randomized controlled trial. [2011.06]
AIM: The present study was undertaken to compare the efficacy of isosorbide mononitrate (IMN) and misoprostol for cervical ripening in termination of pregnancy between 8 and 12 weeks... CONCLUSION: The results show that IMN has a definite role and better safety profile than misoprostol in first trimester cervical ripening, although misoprostol is more effective and causes less blood loss.
Improvement of hypertension and LVH in maintenance hemodialysis patients treated with sustained-release isosorbide mononitrate. [2011.03]
BACKGROUND: Hypertension and left ventricular hypertrophy (LVH) are independent predictors of morbidity and mortality in maintenance hemodialysis (MHD) patients. The level of serum asymmetric dimethylarginine (ADMA) is increased in MHD patients, which is a kind of uremic toxin. It can competitively inhibit nitric oxide production from L-arginine, which can increase vascular resistance, then lead to endothelium dysfunction, hypertension, LVH and decrease of ejection fraction. A sustained-release preparation of isosorbide mononitrate can lead to vasodilatation by releasing nitrogen monoxide. But it remains unclear whether oral isosorbide mononitrate in MHD patients can control blood pressure (BP) and reverse LVH. The aim of the present study was to evaluate the safety and efficacy of oral sustained-release isosorbide mononitrate on hypertension and LVH in MHD patients... CONCLUSIONS: Sustained-release isosorbide mononitrate, which is safe and well tolerated, can effectively control BP, decrease the category and quantity of hypotensive drugs, improve left ventricular hypertrophy and reduce the incidence of acute left heart failure in MHD patients.
Single-dose effects of isosorbide mononitrate alone or in combination with losartan on central blood pressure. [2010.11]
Antihypertensive drugs can have different effects on central and brachial blood pressures, which may affect outcomes. Nitric oxide donors have acute effects on central blood pressure but have not been assessed with renin-angiotensin system blockade...
Effect of isosorbide mononitrate for cervical ripening before surgical termination of pregnancy in the first trimester. [2010.08]
OBJECTIVE: To evaluate the efficacy of isosorbide mononitrate (IMN) for cervical ripening prior to first trimester surgical termination of pregnancy... CONCLUSION: IMN was comparable to placebo in terms of efficacy and patient satisfaction for cervical priming prior to first-trimester termination of pregnancy. Copyright 2010. Published by Elsevier Ireland Ltd.
Clinical Trials Related to Imdur (Isosorbide Mononitrate)
A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis [Recruiting]
This study investigates the effective power of angina pectoris after Quick-Acting Heart
Reliever and isosorbide dinitrate interventing respectively the patients with moderate
coronary stenosis for six months. At the same time, the studying will assess the plaque,
myocardial blood-supplying,quality of life and observe the end point of the heart (including
the myocardial revascularization, death and myocardial infarction). The purpose is to study
the function of the blood-quickening stasis-transforming formula Quick-Acting Heart Reliever
for moderate coronary stenosis lesions.
Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy [Not yet recruiting]
This study is dedicated to determination of the long term effectiveness of coronary heart
disease (CHD) treatments - cardiac shock wave therapy (CSWT) in comparison with other kinds
of medical and surgical treatment. For that purpose the investigators will observe the
patients with CHD who enrolled in this study in their routine course of treatment. But the
investigators will not interfere with the patient treatment. Each participant will be
followed-up for five years. The collected data will allow to determine if the particular
method, CSWT, could really make any additional contribution to the more traditional methods
of CHD treatment and if the CSWT is only temporarily effective or could exert the long term
effect as well.
Intravenous Isosorbide Dinitrate Versus Sublingual Isosorbide Dinitrate for the Relief of Acute Anginal Episodes in Acute Coronary Syndrome (ACS) Patients [Recruiting]
This is a randomized, double blind, placebo-controlled study, clinical trail designed to
evaluate the efficacy safety and superiority of intravenous boluses of isosorbide dinitrate
for the relief of acute anginal pain episodes in acute coronary syndrome patients in
comparison with the usual manner of S/L isosorbide dinitrate .
Trial of Cervical Ripening and Labor Induction Using Misoprostol With or Without Intravaginal Isosorbide Mononitrate [Active, not recruiting]
Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis [Recruiting]
This study will measure and compare changes in insulin production and sensitivity using the
hyperglycemic clamp technique in obese patients with impaired glucose tolerance and
hypertension treated with placebo, isosorbide mononitrate (ISMN) or hydrochlorothiazide
Reports of Suspected Imdur (Isosorbide Mononitrate) Side Effects
Chronic Obstructive Pulmonary Disease (3),
Cardio-Respiratory Arrest (2),
Gastrooesophageal Reflux Disease (2),
Drug Hypersensitivity (2),
Hypertension (2), more >>