Ifex (Ifosfamide / Mesna) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug Interactions

The physician should be alert for possible combined drug actions, desirable or undesirable, involving ifosfamide even though ifosfamide has been used successfully concurrently with other drugs, including other cytotoxic drugs.

OVERDOSAGE

No specific antidote for IFEX is known. Management of overdosage would include general supportive measures to sustain the patient through any period of toxicity that might occur.

CONTRAINDICATIONS

Continued use of IFEX is contraindicated in patients with severely depressed bone marrow function (see WARNINGS and PRECAUTIONS sections). IFEX is also contraindicated in patients who have demonstrated a previous hypersensitivity to it.