Media Articles Related to Ifex (Ifosfamide)
Scientists Discover More Genetic Clues to Testicular Cancer
Source: MedicineNet Testicular Cancer Specialty [2013.05.13]
Title: Scientists Discover More Genetic Clues to Testicular Cancer
Category: Health News
Created: 5/12/2013 2:35:00 PM
Last Editorial Review: 5/13/2013 12:00:00 AM
Testicular Cancer on Rise in U.S., Especially Among Hispanic Men
Source: MedicineNet Testicular Cancer Specialty [2013.05.03]
Title: Testicular Cancer on Rise in U.S., Especially Among Hispanic Men
Category: Health News
Created: 5/3/2013 12:35:00 PM
Last Editorial Review: 5/3/2013 12:00:00 AM
With Testicular Cancer, CT Scan Benefit May Beat Risks
Source: MedicineNet Testicular Cancer Specialty [2012.12.19]
Title: With Testicular Cancer, CT Scan Benefit May Beat Risks
Category: Health News
Created: 12/18/2012 12:36:00 PM
Last Editorial Review: 12/19/2012 12:00:00 AM
Published Studies Related to Ifex (Ifosfamide)
A randomized phase III study comparing standard dose BEP with sequential high-dose cisplatin, etoposide, and ifosfamide (VIP) plus stem-cell support in males with poor-prognosis germ-cell cancer. An intergroup study of EORTC, GTCSG, and Grupo Germinal (EORTC 30974). [2011.05]
CONCLUSION: This study could not demonstrate that high-dose chemotherapy given as part of first-line therapy improves outcome in patients with poor-prognosis GCC.
Phase III trial of standard versus dose-intensified doxorubicin, ifosfamide and dacarbazine (MAID) in the first-line treatment of metastatic and locally advanced soft tissue sarcoma. [2009.10]
Multidrug chemotherapy increases responses in advanced soft tissues sarcoma. Can a 20% increase of relative dose intensity of the MAID regimen, more improve responses? From 1994 to 1997, 162 patients were randomized in a phase III study to the conventional drug combination (6 cycles of MAID: 60, 7,500, 900 mg/m(2) for doxorubicin, ifosfamide and dacarbazine respectively), or at doses 20-33% higher per cycle (5 cycles of intensified MAID for similar cumulative doses) with systematic G-CSF...
Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. [2009.09.01]
PURPOSE: To evaluate the safety and efficacy of trabectedin in a phase II, open-label, multicenter, randomized study in adult patients with unresectable/metastatic liposarcoma or leiomyosarcoma after failure of prior conventional chemotherapy including anthracyclines and ifosfamide... CONCLUSION: Prior studies showed clinical benefit with trabectedin in patients with sarcomas after failure of standard chemotherapy. This trial documents superior disease control with the q3 weeks 24-hour trabectedin regimen in liposarcomas and leiomyosarcomas, although the qwk 3-hour regimen also demonstrated activity relative to historical comparisons. Trabectedin may now be considered an important new option to control advanced sarcomas in patients after failure of available standard-of-care therapies.
Randomized multicenter phase II trial of cisplatin and ifosfamide with or without paclitaxel in recurrent or metastatic carcinoma of the uterine cervix: a Hellenic Cooperative Oncology Group (HeCOG) study. [2009.08]
BACKGROUND: We undertook a randomized phase II trial to test whether the addition of paclitaxel (Taxol) to the cisplatin and ifosfamide (IP) combination could improve objective response (OR) rate, progression-free survival (PFS) and overall survival (OS) in patients with recurrent or metastatic cancer of the uterine cervix... CONCLUSION: The ITP combination merits further investigation in randomized phase III studies.
Chemotherapy: The role of ifosfamide and etoposide in Ewing sarcoma. [2009.05]
The EICESS-92 Trial compared the efficacy of cyclophosphamide and ifosfamide in patients with Ewing sarcoma. Subgroup analysis suggested that patients with large, localized tumors benefited from the addition of etoposide, whereas patients with metastases did not..
Clinical Trials Related to Ifex (Ifosfamide)
Effect on QTc, Pharmacokinetics, Safety, and Preliminary Efficacy of Single-agent Palifosfamide-tris in Subjects With Advanced Solid Tumors [Recruiting]
This is an open-label study of palifosfamide-tris administered intravenously on Days 1, 2,
and 3 of a 21-day cycle to subjects with advanced solid tumors. Enrolled subjects will
receive a placebo-control infusion on Day - 1 and then commence palifosfamide-tris study
treatment 24 hours later on Day 1.
Time-matched, intensive ECG monitoring will occur during and following placebo and
palifosfamide-tris infusions on Days - 1, 1, 2, 3 and 8. Generation of ECG data for study
analysis will be performed in a blinded fashion at a central ECG laboratory.
Blood and urine sampling to characterize the pharmacokinetics of palifosfamide-tris will be
performed on Days 1 through 8 of Cycle 1.
Fosaprepitant in Patients Receiving Ifosfamide-based Regimen [Recruiting]
The goal of this clinical research study is to learn how different doses of fosaprepitant
may effect how ifosfamide-based chemotherapy is absorbed by the body. Researchers also want
to learn if fosaprepitant can help to control or prevent delayed nausea and/or vomiting that
may be caused by chemotherapy. The safety of this drug will also be studied.
Fosaprepitant is designed to block the natural substance in the brain that causes nausea and
vomiting. This may help to prevent and/or control nausea and vomiting caused by
A Scandinavian Sarcoma Group Protocol for Patients With High-risk Soft Tissue Sarcoma of the Extremities and Trunk Wall [Recruiting]
SSG XX is a phase II trial for high-risk soft tissue sarcomas (STS) of the extremities and
trunk wall. Prognostic factors (histopathological markers) are used to identify high-risk
tumors. SSG XX will evaluate chemo- and radiotherapy given adjuvantly to these patients. In
a specified group of patients also preoperatively given therapy will be studied.
Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin [Recruiting]
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, ifosfamide, and carboplatin, work
in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill
more tumor cells. An autologous peripheral stem cell transplant may be able to replace
blood-forming cells that were destroyed by chemotherapy. This may allow more chemotherapy to
be given so that more tumor cells are killed.
PURPOSE: This phase I/II trial is studying the side effects and best dose of ifosfamide when
given together with paclitaxel and carboplatin followed by an autologous stem cell
transplant and to see how well they work in treating patients with germ cell tumors that did
not respond to cisplatin.
Neoadyuvant High-dose of Ifosfamide and Concurrent Radiotherapy in Soft Tissue Sarcoma [Recruiting]
To study the activity and toxicity of a neoadjuvant regimen including high-dose ifosfamide
in combination with radiotherapy, and subsequent surgery, in high-risk soft tissue sarcomas.