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Hyzaar (Losartan Potassium / Hydrochlorothiazide) - Summary

 
 



USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, HYZAAR should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

HYZAAR SUMMARY

USE IN PREGNANCY

HYZAAR 50-12.5 (losartan potassium-hydrochlorothiazide) and HYZAAR 100-25 (losartan potassium-hydrochlorothiazide), combines an angiotensin II receptor (type AT1) antagonist and a diuretic, hydrochlorothiazide.

HYZAAR is indicated for the treatment of hypertension. This fixed dose combination is not indicated for initial therapy of hypertension, except when the hypertension is severe enough that the value of achieving prompt blood pressure control exceeds the risk of initiating combination therapy in these patients (see CLINICAL PHARMACOLOGY, Pharmacodynamics and Clinical Effects, and DOSAGE AND ADMINISTRATION).


See all Hyzaar indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Hyzaar (Losartan / Hydrochlorothiazide)

UF researchers use plants to study new ways of delivering drugs for pulmonary hypertension
Source: Endocrinology News From Medical News Today [2014.10.17]
UF researchers are using the leaves of plants to study new ways to deliver drugs that treat pulmonary hypertension, a disease with few treatment options, according to a study published online in...

Living closer to major roadways increases hypertension risk
Source: Hypertension News From Medical News Today [2014.10.03]
A new study in the Journal of the American Heart Association reports a significant association between living near a major roadway and the risk of high blood pressure.

Hypertension may be initiated by an autoimmune response
Source: Hypertension News From Medical News Today [2014.09.19]
High blood pressure is a major risk factor for heart attack, stroke, chronic heart failure, and kidney disease.

Dementia risk reduction through tobacco control and better prevention, detection and control of hypertension and diabetes
Source: Hypertension News From Medical News Today [2014.09.18]
The World Alzheimer Report 2014 'Dementia and Risk Reduction: An analysis of protective and modifiable factors', calls for dementia to be integrated into both global and national public health...

Men who improve their fitness levels can hold off development of hypertension
Source: Hypertension News From Medical News Today [2014.09.17]
A man's cardiorespiratory fitness can drastically delay the natural, age-associated increase of his blood pressure over his adult life span.

more news >>

Published Studies Related to Hyzaar (Losartan / Hydrochlorothiazide)

Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension. [2009.12]
This study was conducted to determine the effects of a tablet combining losartan/hydrochlorothiazide (L/HCTZ) in comparison with losartan alone in Japanese diabetic patients with hypertension. Thirty consecutive Japanese diabetic patients with hypertension were randomly assigned to group A, receiving losartan alone for the first 3 months, then L/HCTZ for the next 3 months, or group B, receiving L/HCTZ for the first 3 months, then losartan alone for the next 3 months...

A randomized, comparative study evaluating the efficacy and tolerability of losartan-low dose chlorthalidone (6.25 mg) combination with losartan-hydrochlorothiazide (12.5 mg) combination in Indian patients with mild-to-moderate essential hypertension. [2009.07]
OBJECTIVE: The relationship of blood pressure (BP) to cardiovascular risk is linear, positive, and continuous. Lowering elevated BP reduces the risk of cardiovascular events. The primary objective of this randomized, multicenter, comparative, 3-month, open-label study was to evaluate the antihypertensive efficacy of losartan/chlorthalidone versus losartan/hydrochlorothiazide in mild-to-moderate essential hypertension... CONCLUSIONS: The losartan/low-dose chlorthalidone (6.25 mg) combination is as effective as the widely used losartan/hydrochlorothiazide combination in lowering BP and is well tolerated, thus providing a useful therapeutic option for treating mild-to-moderate hypertension.

Effectiveness of open-label losartan/hydrochlorothiazide combination therapy in Asian patients with hypertension not controlled with ACE inhibitor or ARB monotherapy. [2009.06]
Antihypertensive efficacy and safety of losartan/hydrochlorothiazide (HCTZ) combinations have not been adequately studied in Asians. In this open-label, 12-week study in seven Asian areas, patients on monotherapy with angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEIs) but not at blood pressure (BP) goal (sitting diastolic BP (SiDBP) <90 mm Hg in non-diabetics and <80 mm Hg in diabetics) were switched to losartan 50 mg/HCTZ 12.5 mg...

Comparison of therapies between fixed-dose telmisartan/hydrochlorothiazide and losartan/hydrochlorothiazide in patients with mild to moderate hypertension. [2009.01]
Among angiotensin receptor blockers (ARBs), telmisartan is suggested to function as a partial agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma) and to improve lipid and glucose metabolism. Clinical benefits of telmisartan over other ARBs may be apparent in combination with diuretics, which have harmful influences on lipid and glucose metabolism...

Ambulatory blood pressure comparison of the anti-hypertensive efficacy of fixed combinations of irbesartan/hydrochlorothiazide and losartan/hydrochlorothiazide in patients with mild-to-moderate hypertension. [2005.11]
This study examined whether the greater anti-hypertensive efficacy of irbesartan monotherapy over losartan monotherapy extends to the respective fixed-dose combinations with hydrochlorothiazide (HCTZ) in patients with mild-to-moderate hypertension. Patients were treated with either irbesartan 150 mg/HCTZ 12.5 mg or losartan 50 mg/HCTZ 12.5 mg over a 4-week period.

more studies >>

Clinical Trials Related to Hyzaar (Losartan / Hydrochlorothiazide)

HYZAAR vs. Ramipril for Diabetes [Completed]
A study to test the safety and efficacy of HYZAAR as compared to Ramipril in patients with type 2 diabetes mellitus (high blood sugar) and hypertension (high blood pressure).

Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR) [Active, not recruiting]
The primary objective of this study is to determine whether impaired glucose tolerance is improved to a greater degree by Tarka than Hyzaar in subjects with metabolic syndrome

Evaluation of the Antihypertensive Effect of Hyzaar(R) and Cognitive Function of Hypertensive Patients [Completed]
Evaluate the antihypertensive and neuroprotective effects of Hyzaar(R) in elderly subjects in comparison with Natrilix(TM).

Bioequivalence Study of Amlodipine / Losartan/ Hydrochlorothiazide of PHARMALINE, Lebanon Under Fastion Conditions [Recruiting]
To assess the bioequivalence of the investigational TEST product with the marketed REFERENCE products by measurement of Plasma concentrations of Amlodipine ,Losartan, Carboxylic acid losartan metabolite & Hydrochlorothiazide in plasma and calculation of the bioequivalence parameters from those measurements followed by ANOVA and 90% confidence interval statistical evaluation.

Evaluate the Safety and Anti-Hypertensive Efficacy of Hyzaar(R) In Patients With Mild To Moderate Essential Hypertension [Completed]
Evaluate the safety and anti-hypertensive efficacy of hyzaar(R) in patients with mild to moderate essential hypertension.

more trials >>

Reports of Suspected Hyzaar (Losartan / Hydrochlorothiazide) Side Effects

Hyponatraemia (17)Drug Ineffective (11)Rhabdomyolysis (9)Hypokalaemia (9)Malaise (9)Cough (9)Aortic Dissection (8)Dehydration (8)Loss of Consciousness (7)Dizziness (7)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 6 ratings/reviews, Hyzaar has an overall score of 7.83. The effectiveness score is 9.33 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Hyzaar review by 58 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   high blood pressure
Dosage & duration:   50/12.5 mg taken daily for the period of 2 years
Other conditions:   perennial allergic rhinitis
Other drugs taken:   alavert & singulair
  
Reported Results
Benefits:   lowered blood pressure
Side effects:   increased thirst; increased urination;
Comments:   take 1 Hyzaar every morning

 

Hyzaar review by 62 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   High Blood Pressure
Dosage & duration:   standard dosage once a day (dosage frequency: once per day) for the period of 3 years
Other conditions:   irregular heartbeat
Other drugs taken:   just vitamins
  
Reported Results
Benefits:   reduced blood pressure and less water retention in legs and ankles
Side effects:   irregular heartbeat, low pulse rate...heart flutter...
Comments:   When I switched to the generic brand the side effects were moderate to severe, but after returning to the non generic Hyzaar once again, the side effects were less severe and acceptable once again. I wore a heart monitor and took active blood pressure readings in order to determine if the generic brand enhanced the side effects. While still not conclusive in my mind, I've elected to pay the extra dollars for the non generic brand.

 

Hyzaar review by 32 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   High Blood Pressure
Dosage & duration:   25mg taken once daily for the period of 6 months
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Lower my blood pressure out of the Prehypertension range
Side effects:   Tingling in legs (low potassium) which is expected. Unfortunately, it made my heart reate higher & irregular at times (slight flutters) thorughout the day. Ultimately it was difficult to exert myself during exercise b/c I would become exhausted and ouut of breath quickly due to elevated heart rate
Comments:   Simply take the dosage once a day at the same time and monitor my blood pressure

See all Hyzaar reviews / ratings >>

Page last updated: 2014-10-17

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