USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, HYZAAR should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.
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HYZAAR SUMMARY
USE IN PREGNANCY
HYZAAR 50-12.5 (losartan potassium-hydrochlorothiazide) and HYZAAR 100-25 (losartan potassium-hydrochlorothiazide), combines an angiotensin II receptor (type AT1) antagonist and a diuretic, hydrochlorothiazide.
HYZAAR is indicated for the treatment of hypertension. This fixed dose combination is not indicated for initial therapy of hypertension, except when the hypertension is severe enough that the value of achieving prompt blood pressure control exceeds the risk of initiating combination therapy in these patients (see CLINICAL PHARMACOLOGY, Pharmacodynamics and Clinical Effects, and DOSAGE AND ADMINISTRATION).
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NEWS HIGHLIGHTSMedia Articles Related to Hyzaar (Losartan / Hydrochlorothiazide)
New Consortium Paves The Way For Improved Treatment Of Hypertension And Associated Vascular Complications
Source: Hypertension News From Medical News Today [2009.11.18]
Top Institute Pharma (TI Pharma) has formed a consortium with Actelion Pharmaceuticals Ltd, Erasmus Medical Centre and Maastricht University to define new modalities for the treatment of hypertension (high blood pressure) and associated vascular complications such as heart and kidney failure, myocardial infarction and stroke.
Kids with CKD Often Have Masked Hypertension (CME/CE)
Source: MedPage Today Nephrology [2009.11.13]
Many children with chronic kidney disease may have undetected hypertension, placing them at risk for enlarged hearts and future cardiovascular disease, a cross-sectional study showed.
Key Player Identified In Cascade That Leads To Hypertension-Related Kidney Damage
Source: Hypertension News From Medical News Today [2009.11.06]
A key player in a cascade that likely begins with stress and leads to high blood pressure and kidney damage has been identified by researchers who say the finding may lead to better ways to control both. Medical College of Georgia researchers have found endothelin, a powerful blood vessel constrictor and inflammatory peptide, increases the number of T cells in the kidneys, which helps recruit other immune cells, causing inflammation and destruction.
A Recipe For Hypertension: High Fructose Corn Syrup
Source: Hypertension News From Medical News Today [2009.10.31]
A diet high in fructose increases the risk of developing high blood pressure (hypertension), according to a paper presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, California. The findings suggest that cutting back on processed foods and beverages that contain high fructose corn syrup (HFCS) may help prevent hypertension.
Hypertension Guidelines Reappraised In Light Of New Research
Source: Hypertension News From Medical News Today [2009.10.30]
A Task Force of the European Society of Hypertension have released the official European guidelines on the management and treatment of hypertension. The guidelines are an update of those published in 2007, and will be published in the November issue of the Journal of Hypertension.
Published Studies Related to Hyzaar (Losartan / Hydrochlorothiazide)
A randomized, comparative study evaluating the efficacy and tolerability of losartan-low dose chlorthalidone (6.25 mg) combination with losartan-hydrochlorothiazide (12.5 mg) combination in Indian patients with mild-to-moderate essential hypertension. [2009.07]
OBJECTIVE: The relationship of blood pressure (BP) to cardiovascular risk is linear, positive, and continuous. Lowering elevated BP reduces the risk of cardiovascular events. The primary objective of this randomized, multicenter, comparative, 3-month, open-label study was to evaluate the antihypertensive efficacy of losartan/chlorthalidone versus losartan/hydrochlorothiazide in mild-to-moderate essential hypertension... CONCLUSIONS: The losartan/low-dose chlorthalidone (6.25 mg) combination is as effective as the widely used losartan/hydrochlorothiazide combination in lowering BP and is well tolerated, thus providing a useful therapeutic option for treating mild-to-moderate hypertension.
Comparison of therapies between fixed-dose telmisartan/hydrochlorothiazide and losartan/hydrochlorothiazide in patients with mild to moderate hypertension. [2009.01]
Among angiotensin receptor blockers (ARBs), telmisartan is suggested to function as a partial agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma) and to improve lipid and glucose metabolism. Clinical benefits of telmisartan over other ARBs may be apparent in combination with diuretics, which have harmful influences on lipid and glucose metabolism...
Ambulatory blood pressure comparison of the anti-hypertensive efficacy of fixed combinations of irbesartan/hydrochlorothiazide and losartan/hydrochlorothiazide in patients with mild-to-moderate hypertension. [2005.11]
This study examined whether the greater anti-hypertensive efficacy of irbesartan monotherapy over losartan monotherapy extends to the respective fixed-dose combinations with hydrochlorothiazide (HCTZ) in patients with mild-to-moderate hypertension. Patients were treated with either irbesartan 150 mg/HCTZ 12.5 mg or losartan 50 mg/HCTZ 12.5 mg over a 4-week period.
Effects of eplerenone versus losartan in patients with low-renin hypertension. [2005.09]
BACKGROUND: Sodium retention and volume expansion, mediated in part by aldosterone, are prominent features in low-renin hypertension. Agents that block aldosterone at its receptor sites, therefore, should have significant clinical benefit in patients with low-renin hypertension... CONCLUSIONS: These data show that eplerenone was more effective than losartan in reducing blood pressure in patients with low-renin hypertension. Further studies evaluating the efficacy of eplerenone in difficult-to-treat or resistant hypertension are needed.
Telmisartan/Hydrochlorothiazide in comparison with losartan/hydrochlorothiazide in managing patients with mild-to-moderate hypertension. [2005.07]
Hypertension is risk factor for cardiovascular morbidity and mortality, and stroke. A critical surge in blood pressure occurs during the early morning hours coincident with increased incidences of myocardial infarction, unstable angina, stroke and sudden cardiac death... We conclude that T40/H12.5 provided clinically and statistically significantly superior blood pressure reductions compared with L50/H12.5 during the last 6 h of the 24-h dosing interval, which corresponds to the high-risk early-morning hours, and that T80/H12.5 provided additional blood pressure reductions.
Clinical Trials Related to Hyzaar (Losartan / Hydrochlorothiazide)
HYZAAR vs. Ramipril for Diabetes [Completed]
A study to test the safety and efficacy of HYZAAR as compared to Ramipril in patients with
type 2 diabetes mellitus (high blood sugar) and hypertension (high blood pressure).
Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR) [Active, not recruiting]
The primary objective of this study is to determine whether impaired glucose tolerance is
improved to a greater degree by Tarka than Hyzaar in subjects with metabolic syndrome
Evaluation of the Antihypertensive Effect of Hyzaar(R) and Cognitive Function of Hypertensive Patients [Completed]
Evaluate the antihypertensive and neuroprotective effects of Hyzaar(R) in elderly subjects in
comparison with Natrilix(TM).
Evaluate the Safety and Anti-Hypertensive Efficacy of Hyzaar(R) In Patients With Mild To Moderate Essential Hypertension [Completed]
Evaluate the safety and anti-hypertensive efficacy of hyzaar(R) in patients with mild to
moderate essential hypertension.
PROBE Parallel 6-wk Treatment Comparing Telmisartan/HCT (40/12.5 or 80/12.5) With Losartan/HCT (50/12.5) Using ABPM [Completed]
To demonstrate that Telmisartan combined with Hydrochlorothiazide (MICARDIS® HCT) is superior
to Losartan with Hydrochlorothiazide (Hyzaar®) in lowering blood pressure in mild-mod
hypertensives
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 4 ratings/reviews, Hyzaar has an overall score of 8. The effectiveness score is 9.50 and the side effect score is 7.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Hyzaar review by 58 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | high blood pressure |
| Dosage & duration: | | 50/12.5 mg taken daily for the period of 2 years |
| Other conditions: | | perennial allergic rhinitis |
| Other drugs taken: | | alavert & singulair | | |
Reported Results |
| Benefits: | | lowered blood pressure |
| Side effects: | | increased thirst; increased urination; |
| Comments: | | take 1 Hyzaar every morning |
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| | Hyzaar review by 32 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | High Blood Pressure |
| Dosage & duration: | | 25mg taken once daily for the period of 6 months |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | Lower my blood pressure out of the Prehypertension range |
| Side effects: | | Tingling in legs (low potassium) which is expected. Unfortunately, it made my heart reate higher & irregular at times (slight flutters) thorughout the day. Ultimately it was difficult to exert myself during exercise b/c I would become exhausted and ouut of breath quickly due to elevated heart rate |
| Comments: | | Simply take the dosage once a day at the same time and monitor my blood pressure |
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| | Hyzaar review by 32 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | High Blood Pressure |
| Dosage & duration: | | 25mg taken once daily for the period of 6 months |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | Lower my blood pressure out of the Prehypertension range |
| Side effects: | | Tingling in legs (low potassium) which is expected. Unfortunately, it made my heart reate higher & irregular at times (slight flutters) thorughout the day. Ultimately it was difficult to exert myself during exercise b/c I would become exhausted and ouut of breath quickly due to elevated heart rate |
| Comments: | | Simply take the dosage once a day at the same time and monitor my blood pressure |
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Page last updated: 2009-11-18
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