HYDROCORTISONE SUMMARY
HYDROCORTISONE LOTION
USP, 2.5%
Hydrocortisone Ointment USP, 1% contains hydrocortisone [Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11ß)-], with the molecular formula C21H30O5 and molecular weight 362.
Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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NEWS HIGHLIGHTSMedia Articles Related to Hydrocortisone (Hydrocortisone Topical)
hydrocortisone valerate, Westcort
Source: MedicineNet Diaper Rash Specialty [2005.12.13]
Title: hydrocortisone valerate, Westcort
Category: Medications
Created: 4/4/1999 6:03:00 PM
Last Editorial Review: 12/13/2005
Published Studies Related to Hydrocortisone (Hydrocortisone Topical)
Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study. [2009.07]
BACKGROUND: Endogenous plasma cortisol levels have a well-defined circadian rhythm. The aim of this project is to develop a once daily oral dual-release formulation for cortisol replacement therapy that mimics the diurnal variation in the plasma cortisol profile. OBJECTIVE: To determine single-dose plasma pharmacokinetics and dose-proportionality of oral 5 and 20 mg dual-release hydrocortisone tablets in healthy volunteers. In addition, the effect of food intake was investigated for the 20 mg dose. DESIGN: A randomised, controlled, two-way cross-over, double-blind, phase I study of oral hydrocortisone (modified (dual) release; 5 and 20 mg) with an open food-interaction arm... CONCLUSION: The dual release hydrocortisone tablet with once-daily administration produced a diurnal plasma cortisol profile mimicking the physiological serum cortisol profile.
Efficacy of a 0.0584% hydrocortisone aceponate spray in the management of canine atopic dermatitis: a randomised, double blind, placebo-controlled trial. [2009.06]
This study evaluated a 0.0584% hydrocortisone aceponate (HCA) spray (Cortavance; Virbac SA, Carros, France) in canine atopic dermatitis (AD). Initially, dogs with a canine AD extent and severity index (CADESI-03) >or= 50 were randomly allocated to receive HCA (n = 15) or placebo (n = 13) (two sprays from 10 cm away to treat an area of 100 cm(2)) once daily for 28 days...
Effects of yohimbine and hydrocortisone on panic symptoms, autonomic responses, and attention to threat in healthy adults. [2009.06]
RATIONALE: Research in rodents and non-human primates implicates the noradrenergic system and hypothalamic-pituitary-adrenal axis in stress, anxiety, and attention to threat. Few studies examine how these two neurochemical systems interact to influence anxiety and attention in humans. OBJECTIVE: The objective of this paper is to examine the effects of exogenous yohimbine and hydrocortisone, as well as their combination (Y + H), on panic symptoms and attention to social threat cues... CONCLUSIONS: Exogenous hydrocortisone may attenuate noradrenergic-induced panic symptoms. The inverse relationship between panic symptoms and attention to angry faces extends prior research demonstrating attention modulation by stressful conditions.
Stress doses of hydrocortisone in high-risk patients undergoing cardiac surgery: effects on interleukin-6 to interleukin-10 ratio and early outcome. [2009.05]
BACKGROUND: Severe systemic inflammation (systemic inflammatory response syndrome) associated with cardiac surgery often leads to a worse short-term and long-term outcome. Stress doses of hydrocortisone have been successfully used to improve outcome of CS. The interleukin (IL)-6 to IL-10 ratio is associated with outcome after trauma and major surgery. OBJECTIVE: To evaluate immunologic effects (especially IL-6 to IL-10 ratio) of stress doses of hydrocortisone in a high-risk group of patients after cardiac surgery with cardiopulmonary bypass... CONCLUSIONS: Stress doses of hydrocortisone attenuate the evolution of IL-6/IL-10 ratio in patients with systemic inflammatory response syndrome after CS, which seems to be associated with an improved outcome. The immunologic effects of hydrocortisone may thus be both, inhibitory (IL-6) and permissive (IL-10), regarding the immune response.
Modified-release hydrocortisone to provide circadian cortisol profiles. [2009.05]
CONTEXT: Cortisol has a distinct circadian rhythm regulated by the brain's central pacemaker. Loss of this rhythm is associated with metabolic abnormalities, fatigue, and poor quality of life. Conventional glucocorticoid replacement cannot replicate this rhythm. OBJECTIVES: Our objectives were to define key variables of physiological cortisol rhythm, and by pharmacokinetic modeling test whether modified-release hydrocortisone (MR-HC) can provide circadian cortisol profiles. SETTING: The study was performed at a Clinical Research Facility... CONCLUSION: By defining circadian rhythms and using modern formulation technology, it is possible to allow a more physiological circadian replacement of cortisol.
Clinical Trials Related to Hydrocortisone (Hydrocortisone Topical)
Adherence to Topical Hydrocortisone 17-Butyrate 0.1% (LocoidŽ) Using Different Vehicles in Adults With Atopic Dermatitis [Active, not recruiting]
The purpose of this research study is to better understand how the study drug Locoid works
when people use it to treat atopic dermatitis.
Ketoconazole, Hydrocortisone and Dutasteride in Asymptomatic Hormone Refractory Prostate Cancer [Active, not recruiting]
The combination of ketaconazole and hydrocortisone is commonly used for the treatment of
prostate cancer. The purpose of this study is to determine if the addition of a drug called
dutasteride to this approved combination will make the combination more effective in treating
prostate cancer.
Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response? [Active, not recruiting]
The primary purpose of this study is to examine whether IV hydrocortisone can speed up the
time required for Venlafaxine XR to work.
Efficacy Study of Low-Dose Hydrocortisone Treatment for Fibromyalgia [Completed]
This study is based on clinical findings that some patients with fibromyalgia have a tendency
towards lower levels of the stress hormone cortisol. The hypothesis to be tested in this
study is that the administration of a very low-dose of cortisol which has no side effects
corrects this deficiency and results in an improvement of symptoms
Cortisol Control of Human Inflammatory Responses to Endotoxin [Completed]
The purpose of the research is to study a common and dangerous medical condition called
'septic shock' that often occurs in critically ill patients. In order to learn about septic
shock in humans, we will administer a substance called 'endotoxin' to participants in this
study. Endotoxin causes a temporary period of inflammation in the human body, a brief
'virtual' infection. This is an established method for the investigation of inflammation
properties. We are interested in how the natural hormone, cortisol, can affect the human
response to endotoxin. We know that when cortisol is given at the same time as endotoxin it
can decrease the inflammation that occurs due to endotoxin. In this study we will test
whether or not cortisol, when given the day before the endotoxin, will work to change the
inflammation that occurs due to endotoxin. In order to test this, two-thirds of the study
participants will receive cortisol on the day before they receive the endotoxin and one-third
of the study participants will receive a placebo (no medication) before the endotoxin.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Hydrocortisone has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Hydrocortisone review by 47 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | eczema |
| Dosage & duration: | | thin film (dosage frequency: 2-3 times daily) for the period of 3 weeks |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | This cleared up severe cracking and bleeding on hand. I have managed to avoid the condition for many months due to proper moisturization. |
| Side effects: | | there were none, but I was warned that overusage could thin the skin. |
| Comments: | | I was instructed to apply to affected area in the morning on slightly damp skin. I was to reapply a couple more times a day (especially after hand washing). And to keep skin constantly moisturized. |
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Page last updated: 2009-10-20
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