NEWS HIGHLIGHTSMedia Articles Related to Hydrocortisone and Acetic Acid (Hydrocortisone / Acetic Acid Otic)
Cells That Control Inflammation In Chronic Disease
Source: Respiratory / Asthma News From Medical News Today [2009.11.19]
A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation.
Inflammation Critical In Aortic Dissection: UTMB
Source: Biology / Biochemistry News From Medical News Today [2009.11.17]
The aorta, the body's largest artery, stretches from the chest to below the kidneys, expanding and contracting with the pressure of blood driven directly into it by the heart. Although its walls are extraordinarily strong, like other blood vessels the aorta can sometimes develop bulges, called aneurysms.
Researchers Find New Way To Attack Inflammation In Graves' Eye Disease
Source: Eye Health / Blindness News From Medical News Today [2009.11.07]
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms and improved vision following treatment with the drug rituximab. Inflammation around their eyes and damage to the optic nerve were significantly reduced. The same patients had not previously responded to steroids, a common treatment for Graves' eye disease. Raymond S. Douglas, M.D., Ph.D.
High Blood Pressure And Markers Of Inflammation In Blood More Common In Offspring Of Parents With Alzheimer's Disease
Source: Hypertension News From Medical News Today [2009.11.04]
High blood pressure, evidence of arterial disease and markers of inflammation in the blood in middle age appear more common in individuals whose parents have Alzheimer's disease than in individuals without a parental history of the condition, according to a report in the November issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
More Needs To Be Done To Prevent Hearing Loss From Middle Ear Inflammation Among Indigenous Children, Australia
Source: Ear, Nose and Throat News From Medical News Today [2009.11.03]
More needs to be done to prevent and treat otitis media (otherwise known as middle ear inflammation), which is a major health problem in Indigenous communities and can lead to permanent hearing loss, according to the editor of a supplement on the condition published in the 2 November issue of the Medical Journal of Australia. Each year, three to five Australian children die from complications related to otitis media and another 15 suffer permanent hearing loss.
Published Studies Related to Hydrocortisone and Acetic Acid (Hydrocortisone / Acetic Acid Otic)
Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. [1991.08.08]
We have previously shown that chronic sucralfate ingestion stimulates gastric epithelial proliferation in rats, which may explain one of the beneficial effects of sucralfate in healing of peptic ulcers. In a separate study, we have found that chronic steroid administration delays the healing of experimental gastric ulcers in rats...
Effects of prostaglandins on hydrocortisone-induced delayed healing of chronic gastric ulcers in the rat. [1991]
We have previously shown that chronic steroid administration delays the healing of experimental gastric ulcers in rats. This study was designed to test the beneficial effects of 16,16-dimethylprostaglandin E2 or TRY-200, a stable prostaglandin I2 analogue, on the delayed healing by hydrocortisone (HC) of chronic gastric ulcers in rats...
Kinetics of drug release from polylactic acid-hydrocortisone microcapsules. [1986.07]
Polylactic acid microcapsules of similar particle size distribution containing various drug loadings of hydrocortisone were prepared. The microcapsules, which contained randomly dispensed drug particles, showed a dissolution pattern which consists of a fast first-stage and a slow second-stage drug release.
Clinical Trials Related to Hydrocortisone and Acetic Acid (Hydrocortisone / Acetic Acid Otic)
Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response? [Active, not recruiting]
The primary purpose of this study is to examine whether IV hydrocortisone can speed up the
time required for Venlafaxine XR to work.
Efficacy Study of Low-Dose Hydrocortisone Treatment for Fibromyalgia [Completed]
This study is based on clinical findings that some patients with fibromyalgia have a tendency
towards lower levels of the stress hormone cortisol. The hypothesis to be tested in this
study is that the administration of a very low-dose of cortisol which has no side effects
corrects this deficiency and results in an improvement of symptoms
Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure [Completed]
Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects
of physiological cortisol substitution and withdrawal is studied and related to the clinical
syndrome of adrenal insufficiency.
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag [Active, not recruiting]
This study will examine the effects of cortisol (hydrocortisone), melatonin, a combination of
cortisol and melatonin, and placebo (an inactive substance) on jet lag symptoms. Jet lag is a
term used to describe symptoms people commonly experience after rapid travel across several
time zones. The cause of jet lag is not known, but various hormones, including cortisol and
melatonin, have a day-to-night pattern of secretion and play a role in maintaining the body's
internal rhythms. This study will test whether taking cortisol, melatonin, or both can help
re-establish the body's day-night cycle and result in less jet lag.
People between 18 and 65 years of age who are planning a non-stop eastward flight with the
following characteristics may be eligible for this study:
- Crossing six to eight time zones (6 to 8 hours difference between Eastern Standard Time
and the destination)
- Destination between 30 and 50 latitudes (approximately Cairo to London)
- Evening flight (5 PM to midnight) with morning arrival
- Remaining abroad at least 4-10 days
Candidates must have a body mass index (BMI) between 20 and 30 kg/M (not too thin and not
overweight) and must not be taking medicines that affect sleep or cortisol or melatonin
levels. Prospective participants are screened with a medical history, blood tests, and check
of blood pressure, height, and weight.
Pre-flight Procedures
Participants keep a sleep journal 3 days before the flight. For 1 day within 3 days of the
flight they fill out jet lag and sleepiness questionnaires and collect morning and bedtime
saliva samples for measurement of cortisol and melatonin. The saliva is collected by chewing
on two small cotton pads and spitting them into a tube. Premenopausal women provide a urine
sample the week before the flight to test for pregnancy. On the day of the flight, the
participants do not collect saliva or fill out sleep logs or questionnaires. They are given
two bottles with study medication. One bottle, labeled "AM," contains either hydrocortisone
or placebo; the other, labeled "PM," contains either melatonin or placebo.
Post-flight Procedures
Upon arriving at their destination in the morning, participants obtain a saliva sample and
take one of the capsules in the "AM" bottle. At bedtime, they collect saliva and then take
one of the "PM" capsules. They repeat the medication doses for a total of 4 days and repeat
the saliva collections on days 2 through 4, 7 and 10 after arrival. In addition, participants
complete jet lag and sleep questionnaires in the morning, afternoon, and just before bedtime
on the day of arrival and on days 2 through 4, 7 and 10.
After they return from their trip, participants are seen at the NIH Clinic to bring in their
saliva specimens and review their questionnaires with study investigators.
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis [Completed]
The purpose of this pilot study is to (1) examine the changes in gene expression in patients
who suffer from severe sepsis and whose shock (inadequate oxygen delivery to vital organs)
state does not respond to fluid and vasopressor administration, (2) to show that our sampling
method of isolating RNA provides reliable and consistent data, (3) provide a basis for future
gene expression studies in critically ill patients
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