SUMMARY
HYDROCODONE BITARTRATE AND ACETAMINOPHEN TABLETS USP
10 mg/650 mg
Each tablet, for oral administration, contains hydrocodone bitartrate
(WARNING: May be habit forming) and acetaminophen in the following strengths:
Hydrocodone bitartrate, USP - 7.5 mg
Acetaminophen, USP - 500 mg
Hydrocodone bitartrate, USP - 7.5 mg
Acetaminophen, USP - 650 mg
Hydrocodone bitartrate, USP - 10 mg
Acetaminophen, USP - 650 mg
Hydrocodone bitartrate and acetaminophen tablets are indicated for the relief of moderate to moderately severe pain.
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NEWS HIGHLIGHTSMedia Articles Related to Hydrocodone and Acetaminophen (Hydrocodone / Acetaminophen)
hydrocodone/acetaminophen, Vicodin, Vicodin ES, Anexsia, Lorcet, Lorcet Plus, Norco
Source: MedicineNet Coccydynia Specialty [2008.01.07]
Title: hydrocodone/acetaminophen, Vicodin, Vicodin ES, Anexsia, Lorcet, Lorcet Plus, Norco
Category: Medications
Created: 12/31/1997
Last Editorial Review: 1/7/2008
Published Studies Related to Hydrocodone and Acetaminophen (Hydrocodone / Acetaminophen)
Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers. [2009.04.01]
BACKGROUND: Non-medical use and abuse of prescription opioids is a significant problem in the United States. Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids. The purpose of this study was to directly compare the psychopharmacological profile of two widely prescribed and abused oral opioid combination products within the same subject... CONCLUSIONS: Consistent with a recent study published in this journal using identical doses of HYD and OXY (without ACET) in prescription opioid abusers (Walsh, S.L., Nuzzo, P.A., Lofwall, M.R., Holtman Jr., J.R., 2008. The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription drug abusers. Drug Alcohol Depend. 198, 191-202), we found little difference in the pharmacodynamic effects of HYD/ACET and OXY/ACET in non-drug-abusing volunteers.
Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial. [2008.01]
OBJETIVES: The purpose of this study was to compare the analgesic efficacy and tolerability of opioids hydrocodone and tramadol in the relief of cancer pain... CONCLUSIONS: There was no superior analgesic efficacy with the administration of hydrocodone/acetaminophen when compared to patients receiving tramadol in the relief of cancer pain. Tramadol produced more mild side effects than hydrocodone.
Tramadol/acetaminophen or hydrocodone/acetaminophen for the treatment of ankle sprain: a randomized, placebo-controlled trial. [2007.04]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.
Tramadol/Acetaminophen or Hydrocodone/Acetaminophen for the Treatment of Ankle Sprain: A Randomized, Placebo-Controlled Trial. [2006.11.17]
STUDY OBJECTIVE: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain... CONCLUSION: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.
Rofecoxib versus hydrocodone/acetaminophen for postoperative analgesia in functional endoscopic sinus surgery. [2006.04]
OBJECTIVES/HYPOTHESIS: Functional endoscopic sinus surgery (FESS) is less invasive and more tissue sparing than extirpative techniques, with an assumed benefit of diminished postoperative pain. Oral opioids are commonly prescribed after sinus surgery but are associated with adverse effects, including gastrointestinal and neurologic symptoms. Nonopioid analgesics have been suggested to offer similar pain control efficacy with fewer adverse effects. STUDY DESIGN: To investigate postoperative analgesia in FESS, a prospective randomized, double-blinded comparison of hydrocodone/acetaminophen 7.5/750 mg (an opioidderivative) with rofecoxib 50 mg (a cyclooxygenase-2 inhibitor) was performed... CONCLUSIONS: The use of nonopioid analgesics after FESS may provide similar pain control to oral opioids.
Clinical Trials Related to Hydrocodone and Acetaminophen (Hydrocodone / Acetaminophen)
A CCRC Study: A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine [Active, not recruiting]
A Study Comparing VicodinŽ CR and NORCOŽ to Placebo in Subjects With Acute Pain Following Bunionectomy [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of Extended Release Hydrocodone/Acetaminophen and Immediate Release
Hydrocodone/Acetaminophen with placebo over a 12 hour dosing period in patients who have had
a bunionectomy, and to assess the safety of the drug for 7 days after patients are discharged
from the hospital.
A Study Comparing the Analgesic Activity of Extended Release Hydrocodone/Acetaminophen (VicodinŽ CR) and Placebo in Subjects With Pain Following Bunionectomy Surgery [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of 2 different dose levels of Extended Release
Hydrocodone/Acetaminophen with placebo over a 48 hour dosing period in patients who have had
bunionectomy surgery, and to assess the safety of the drug for 7 days after patients are
discharged from the hospital.
A Study Comparing the Analgesic Efficacy and Safety of Extended Release Hydrocodone/Acetaminophen (VicodinŽ CR)and Placebo in Subjects With Osteoarthritis [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of Extended Release Hydrocodone/Acetaminophen with placebo over a
5-week dosing period in patients with osteoarthritis.
A Study of Extended-Release Hydrocodone/Acetaminophen (Vicodin CRŽ) in Subjects With Acute Pain Following Bunionectomy [Completed]
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety
of the administration of Extended-Release Hydrocodone/Acetaminophen compared to placebo over
a 48 hour dosing period in patients who have had bunionectomy surgery and to assess the
safety of the drug for 7 days after patients are discharged from the hospital.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Hydrocodone and Acetaminophen has an overall score of 9. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Hydrocodone and Acetaminophen review by 54 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | cervical spondylosis |
| Dosage & duration: | | 7.5-325 every 6 hrs. (dosage frequency: as directed) for the period of 4 weeks |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Drug offers reliable pain relief with little negative side affects. Pain in neck, left shoulder, arm and hand. Numbness in hand and fingers. Did not experience any nausea, dizziness. |
| Side effects: | | Loss of appetite, drowsiness, sleepiness. |
| Comments: | | Cervical spondylosis. Attempted to treat conservatively with chiropractics, including stimulation therapy, traction, cold therapy and medication. Surgery required to fuse C5,6,7. Peruneural root cyst C6. Inoperable. |
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Page last updated: 2009-10-20
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