ADVERSE REACTIONS
The adverse reactions associated with hydrochlorothiazide have been shown to be dose related. In controlled clinical trials, the adverse events reported with doses of 12.5 mg hydrochlorothiazide once daily were comparable to placebo. The following adverse reactions have been reported for doses of hydrochlorothiazide 25 mg and greater and, within each category, are listed in the order of decreasing severity.
Body as a whole: Weakness.
Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).
Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.
Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.
Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.
Metabolic: Electrolyte imbalance (see PRECAUTIONS), hyperglycemia, glycosuria, hyperuricemia.
Musculoskeletal: Muscle Spasm.
Nervous System/Psychiatric: Vertigo, paresthesia, dizziness, headache, restlessness.
Renal: Renal failure, renal dysfunction, interstitial nephritis (see WARNINGS).
Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.
Special Senses: Transient blurred vision, xanthopsia.
Urogenital: Impotence.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.
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REPORTS OF SUSPECTED HYDROCHLOROTHIAZIDE SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Hydrochlorothiazide. The information is not vetted and should not be considered as verified clinical evidence.
Possible Hydrochlorothiazide side effects / adverse reactions in 92 year old male
Reported by a consumer/non-health professional from United States on 2011-10-03
Patient: 92 year old male
Reactions: Inappropriate Schedule of Drug Administration, Syncope, Dizziness
Suspect drug(s):
Aspirin
Indication: Product Used FOR Unknown Indication
Lipitor
Indication: Product Used FOR Unknown Indication
Avodart
Dosage: (1 dosage forms, 1 wk), oral
Administration route: Oral
Indication: Benign Prostatic Hyperplasia
Prilosec
Dosage: oral
Indication: Product Used FOR Unknown Indication
Hydrochlorothiazide
Dosage: (12.5 mg), oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lisinopril
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Coreg
Indication: Product Used FOR Unknown Indication
Flomax
Indication: Product Used FOR Unknown Indication
Acetaminophen
Indication: Product Used FOR Unknown Indication
Possible Hydrochlorothiazide side effects / adverse reactions in 76 year old male
Reported by a pharmacist from United States on 2011-10-03
Patient: 76 year old male
Reactions: Mental Status Changes, Hyponatraemia
Adverse event resulted in: hospitalization
Suspect drug(s):
Hydrochlorothiazide
Possible Hydrochlorothiazide side effects / adverse reactions in 63 year old female
Reported by a physician from Spain on 2011-10-03
Patient: 63 year old female
Reactions: Photosensitivity Reaction, Urticaria Papular
Suspect drug(s):
Crestor
Administration route: Oral
Start date: 2010-12-01
End date: 2011-03-01
Hydrochlorothiazide
Administration route: Oral
Start date: 2010-12-01
End date: 2011-03-01
Multaq
Administration route: Oral
Indication: Atrial Fibrillation
Start date: 2011-01-01
End date: 2011-03-01
Doxylamine Succinate
Administration route: Oral
End date: 2011-09-01
Other drugs received by patient: Sintrom; Omeprazole
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