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Hydrochlorothiazide (Hydrochlorothiazide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The adverse reactions associated with hydrochlorothiazide have been shown to be dose related. In controlled clinical trials, the adverse events reported with doses of 12.5 mg hydrochlorothiazide once daily were comparable to placebo. The following adverse reactions have been reported for doses of hydrochlorothiazide 25 mg and greater and, within each category, are listed in the order of decreasing severity.
Body as a whole: Weakness.
Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).
Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.
Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.
Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.
Metabolic: Electrolyte imbalance (see PRECAUTIONS), hyperglycemia, glycosuria, hyperuricemia.
Musculoskeletal: Muscle Spasm.
Nervous System/Psychiatric: Vertigo, paresthesia, dizziness, headache, restlessness.
Renal: Renal failure, renal dysfunction, interstitial nephritis (see WARNINGS).
Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.
Special Senses: Transient blurred vision, xanthopsia.
Urogenital: Impotence.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.



REPORTS OF SUSPECTED HYDROCHLOROTHIAZIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Hydrochlorothiazide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Hydrochlorothiazide side effects / adverse reactions in 92 year old male

Reported by a consumer/non-health professional from United States on 2011-10-03

Patient: 92 year old male

Reactions: Inappropriate Schedule of Drug Administration, Syncope, Dizziness

Suspect drug(s):
Aspirin
    Indication: Product Used FOR Unknown Indication

Lipitor
    Indication: Product Used FOR Unknown Indication

Avodart
    Dosage: (1 dosage forms, 1 wk), oral
    Administration route: Oral
    Indication: Benign Prostatic Hyperplasia

Prilosec
    Dosage: oral
    Indication: Product Used FOR Unknown Indication

Hydrochlorothiazide
    Dosage: (12.5 mg), oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Lisinopril
    Dosage: oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Coreg
    Indication: Product Used FOR Unknown Indication

Flomax
    Indication: Product Used FOR Unknown Indication

Acetaminophen
    Indication: Product Used FOR Unknown Indication



Possible Hydrochlorothiazide side effects / adverse reactions in 76 year old male

Reported by a pharmacist from United States on 2011-10-03

Patient: 76 year old male

Reactions: Mental Status Changes, Hyponatraemia

Adverse event resulted in: hospitalization

Suspect drug(s):
Hydrochlorothiazide



Possible Hydrochlorothiazide side effects / adverse reactions in 63 year old female

Reported by a physician from Spain on 2011-10-03

Patient: 63 year old female

Reactions: Photosensitivity Reaction, Urticaria Papular

Suspect drug(s):
Crestor
    Administration route: Oral
    Start date: 2010-12-01
    End date: 2011-03-01

Hydrochlorothiazide
    Administration route: Oral
    Start date: 2010-12-01
    End date: 2011-03-01

Multaq
    Administration route: Oral
    Indication: Atrial Fibrillation
    Start date: 2011-01-01
    End date: 2011-03-01

Doxylamine Succinate
    Administration route: Oral
    End date: 2011-09-01

Other drugs received by patient: Sintrom; Omeprazole



See index of all Hydrochlorothiazide side effect reports >>

Drug label data at the top of this Page last updated: 2011-08-30

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