Hydrochlorothiazide (Hydrochlorothiazide) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The adverse reactions associated with hydrochlorothiazide have been shown to be dose related. In controlled clinical trials, the adverse events reported with doses of 12.5 mg hydrochlorothiazide once daily were comparable to placebo. The following adverse reactions have been reported for doses of hydrochlorothiazide 25 mg and greater and, within each category, are listed in the order of decreasing severity.

Body as a whole: Weakness.

Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).

Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.

Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.

Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.

Metabolic: Electrolyte imbalance (see PRECAUTIONS), hyperglycemia, glycosuria, hyperuricemia.

Musculoskeletal: Muscle Spasm.

Nervous System/Psychiatric: Vertigo, paresthesia, dizziness, headache, restlessness.

Renal: Renal failure, renal dysfunction, interstitial nephritis (see WARNINGS).

Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.

Special Senses: Transient blurred vision, xanthopsia.

Urogenital: Impotence.

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO HYDROCHLOROTHIAZIDE

Possible Hydrochlorothiazide side effects / adverse reactions in 56 year old male

Reported by a physician from United States on 2007-01-02

Patient: 56 year old male weighing 76.0 kg (167.2 pounds)

Reactions: Pancreatitis

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Hydrochlorothiazide

Other drugs received by patient: Aripiprazole; Aspirin; Atenolol; Hydrochlorothiazide; Hydroxyzine; Ketoconazole; Nicotine

Possible Hydrochlorothiazide side effects / adverse reactions in 75 year old male

Reported by a individual with unspecified qualification on 2007-01-08

Patient: 75 year old male

Reactions: Renal Impairment, Hyperkalaemia, Blood Creatinine Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
Oxycodone HCL
    Dosage: 5 mg, prn
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Omeprazole
    Dosage: 20 mg, unk
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2006-11-06
    End date: 2006-11-13

Irbesartan
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    End date: 2006-11-08

Irbesartan
    Dosage: 75 mg, unk
    Administration route: Oral
    Start date: 2006-11-13

Alendronate Sodium
    Dosage: 10 mg, unk
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    Start date: 2006-11-06

Hydrochlorothiazide
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication
    End date: 2006-11-08

Folic Acid
    Dosage: 5 mg, unk
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Other drugs received by patient: Insulin; Vitamin D3; Carvedilol; Magnesium; Simvastatin; Acetaminophen; Coloxyl with Senna; Calcium; Frusemide; Gliclazide; Spironolactone; Aspirin

Possible Hydrochlorothiazide side effects / adverse reactions in 61 year old male

Reported by a individual with unspecified qualification on 2007-01-12

Patient: 61 year old male

Reactions: Nodal Rhythm, Disorientation, Sinus Arrest, Blood Pressure Decreased, Lethargy

Adverse event resulted in: hospitalization

Suspect drug(s):
Hydrochlorothiazide
    Indication: Hypertension

Nadolol
    Indication: Hypertension

Diltiazem HCL
    Indication: Hypertension

Irbesartan
    Indication: Hypertension

Other drugs received by patient: Other Drugs