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Hydrochlorothiazide (Hydrochlorothiazide) - Indications and Dosage



Hydrochlorothiazide Capsules are indicated in the management of hypertension either as the sole therapeutic agent, or in combination with other antihypertensives. Unlike potassium sparing combination diuretic products, Hydrochlorothiazide Capsules may be used in those patients in whom the development of hyperkalemia cannot be risked, including patients taking ACE inhibitors.
Usage in Pregnancy: The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.
Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy resulting from restriction of venous return by the expanded uterus is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances this edema may cause extreme discomfort which is not relieved by rest. In these cases a short course of diuretics may provide relief and may be appropriate.


For Control of Hypertension: The adult initial dose of hydrochlorothiazide capsules is one capsule given once daily whether given alone or in combination with other antihypertensives. Total daily doses greater than 50 mg are not recommended.


Hydrochlorothiazide capsules 12.5 mg are:
Teal/Teal colored size4'hard gelatin capsules withHP45'imprinted in black on Cap and Body, filled with white to off-white powder. They are supplied in the following package sizes:
Bottles of 30 Capsules (NDC 23155-045-03)
Bottles of 100 Capsules (NDC 23155-045-01)
Bottles of 500 Capsules (NDC 23155-045-05)
Bottles of 1000 Capsules (NDC 23155-045-10)
Store at 20to 25(68to 77to 30(59to 86[see USP Controlled Room Temperature]. Protect from light, moisture and freezing, -20(-4
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Manufactured for:
Heritage Pharmaceuticals Inc.
Edison, NJ 08837
1.866.901. DRUG (3784)
Manufactured by:
Ipca Laboratories Limited
48, Kandivli Ind. Estate, Mumbai 400 067, India.

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