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Hydralazine (Hydralazine Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc



HYDRALAZINE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.


Acute Toxicity

No deaths due to acute poisoning have been reported.

      Highest known dose survived: adults, 10 g orally.

      Oral LD50 in rats: 173 and 187 mg/kg.

Signs and Symptoms

Signs and symptoms of overdosage include hypotension, tachycardia, headache, and generalized skin flushing.

Complications can include myocardial ischemia and subsequent myocardial infarction, cardiac arrhythmia, and profound shock.


There is no specific antidote.

Support of the cardiovascular system is of primary importance.  Shock should be treated with plasma expanders.  If possible, vasopressors should not be given, but if a vasopressor is required, care should be taken not to precipitate or aggravate cardiac arrhythmia.  Tachycardia responds to beta blockers.  Digitalization may be necessary, and renal function should be monitored and supported as required.

No experience has been reported with extracorporeal or peritoneal dialysis.


Hypersensitivity to hydralazine, coronary artery disease, mitral valvular rheumatic heart disease.

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