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Hycodan (Hydrocodone Bitartrate / Homatropine Methylbromide) - Summary

 
 



HYCODAN SUMMARY

ANTITUSSIVE

HYCODAN®
(Hydrocodone Bitartrate and Homatropine Methylbromide)
TABLETS AND SYRUP

CIII

Rx only

HYCODAN contains hydrocodone (dihydrocodeinone) bitartrate, a semisynthetic centrally-acting opioid antitussive. Homatropine methylbromide is included in a subtherapeutic amount to discourage deliberate overdosage.

HYCODAN (hydrocodone bitartrate and homatropine methylbromide) is indicated for the symptomatic relief of cough.


See all Hycodan indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Hycodan (Hydrocodone / Homatropine)

Whooping Cough Vaccine Rates During Pregnancy Fall Short: CDC
Source: MedicineNet Pertussis Specialty [2014.09.26]
Title: Whooping Cough Vaccine Rates During Pregnancy Fall Short: CDC
Category: Health News
Created: 9/25/2014 4:36:00 PM
Last Editorial Review: 9/26/2014 12:00:00 AM

Persistent Cough in Kids Can Often Be Whooping Cough
Source: MedicineNet Pertussis Specialty [2014.06.25]
Title: Persistent Cough in Kids Can Often Be Whooping Cough
Category: Health News
Created: 6/25/2014 9:35:00 AM
Last Editorial Review: 6/25/2014 12:00:00 AM

Pertussis and Whooping Cough Pictures Slideshow: Is Your Child Protected?
Source: MedicineNet Immunizations Specialty [2014.06.20]
Title: Pertussis and Whooping Cough Pictures Slideshow: Is Your Child Protected?
Category: Slideshows
Created: 1/27/2010 1:05:00 PM
Last Editorial Review: 6/20/2014 12:00:00 AM

OTC Cold and Cough Medications
Source: MedicineNet Allergy Treatment Begins At Home Specialty [2014.02.05]
Title: OTC Cold and Cough Medications
Category: Doctor's & Expert's views on Symptoms
Created: 2/8/2005 12:00:00 AM
Last Editorial Review: 2/5/2014 12:00:00 AM

Cough
Source: MedicineNet Alpha 1 Antitrypsin Deficiency Specialty [2014.02.04]
Title: Cough
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/4/2014 12:00:00 AM

more news >>

Published Studies Related to Hycodan (Hydrocodone / Homatropine)

A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. [2010.02]
OBJECTIVES: To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy. METHODS: Children 6 to 15 years of age were randomized to receive acetaminophen and hydrocodone (167 mg/2.5 mg/5 mL) for 3 days after surgery: Group A (N=39)-every 4 hours PRN, with standard postoperative instructions; Group B (N=34)-every 4 hours ATC, with standard postoperative instructions, without nurse coaching; and Group C (N=40)-every 4 hours ATC, with standard postoperative instructions, with coaching...

A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. [2010]
OBJECTIVES: To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy. METHODS: Children 6 to 15 years of age were randomized to receive acetaminophen and hydrocodone (167 mg/2.5 mg/5 mL) for 3 days after surgery: Group A (N=39)-every 4 hours PRN, with standard postoperative instructions; Group B (N=34)-every 4 hours ATC, with standard postoperative instructions, without nurse coaching; and Group C (N=40)-every 4 hours ATC, with standard postoperative instructions, with coaching...

Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers. [2009.04.01]
BACKGROUND: Non-medical use and abuse of prescription opioids is a significant problem in the United States. Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids. The purpose of this study was to directly compare the psychopharmacological profile of two widely prescribed and abused oral opioid combination products within the same subject... CONCLUSIONS: Consistent with a recent study published in this journal using identical doses of HYD and OXY (without ACET) in prescription opioid abusers (Walsh, S.L., Nuzzo, P.A., Lofwall, M.R., Holtman Jr., J.R., 2008. The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription drug abusers. Drug Alcohol Depend. 198, 191-202), we found little difference in the pharmacodynamic effects of HYD/ACET and OXY/ACET in non-drug-abusing volunteers.

Determination and pharmacokinetic study of hydrocodone in human plasma by liquid chromatography coupled with tandem mass spectrometry. [2009]
A rapid, highly sensitive and specific high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS-MS) quantitation method was developed and validated for the determination of hydrocodone in human plasma. Sample was extracted from 0.5mL heparinized plasma by a simple liquid-liquid extraction method and analyzed on a C18 column with a mobile phase of acetonitrile-water (78:22,v/v,0.1% acetic acid)...

Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial. [2008.01]
OBJETIVES: The purpose of this study was to compare the analgesic efficacy and tolerability of opioids hydrocodone and tramadol in the relief of cancer pain... CONCLUSIONS: There was no superior analgesic efficacy with the administration of hydrocodone/acetaminophen when compared to patients receiving tramadol in the relief of cancer pain. Tramadol produced more mild side effects than hydrocodone.

more studies >>

Clinical Trials Related to Hycodan (Hydrocodone / Homatropine)

Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco [Recruiting]
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.

A Study to Evaluate the Pharmacokinetics of the Hydrocodone Extended-Release Tablet (CEP-33237) in Subjects With Normal Hepatic Function and Subjects With Moderate Hepatic Impairment [Recruiting]
The purpose of this study is:

1. To assess the pharmacokinetics of the hydrocodone bitartrate extended-release tablet in subjects with moderate hepatic impairment and in subjects with normal hepatic function.

2. To assess the safety and tolerability of the hydrocodone bitartrate extended-release tablet in subjects with moderate hepatic impairment and in subjects with normal hepatic function.

A Crossover Study to Assess the Bioequivalence of Hydrocodone Bitartrate Extended-Release Tablet [Recruiting]
The primary objective of this study is to assess the bioequivalence of two 45-mg hydrocodone bitartrate extended-release tablets and one 90-mg hydrocodone bitartrate extended-release tablet.

Efficacy and Safety of Hydrocodone Bitartrate (HYD) in Subjects With Moderate to Severe Chronic Low Back Pain [Recruiting]
The primary objective of this study is to evaluate the analgesic efficacy and safety of HYD tablets 20 to 120 mg once-daily dose compared to placebo in subjects with moderate to severe chronic low back pain uncontrolled by their current stable analgesic regimen

Hydrocodone For Pain Control in First Trimester Surgical Abortion [Recruiting]
The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.

more trials >>


Page last updated: 2014-09-26

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