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Hycodan (Hydrocodone Bitartrate / Homatropine Methylbromide) - Summary

 
 



HYCODAN SUMMARY

ANTITUSSIVE

HYCODAN®
(Hydrocodone Bitartrate and Homatropine Methylbromide)
TABLETS AND SYRUP

CIII

Rx only

HYCODAN contains hydrocodone (dihydrocodeinone) bitartrate, a semisynthetic centrally-acting opioid antitussive. Homatropine methylbromide is included in a subtherapeutic amount to discourage deliberate overdosage.

HYCODAN (hydrocodone bitartrate and homatropine methylbromide) is indicated for the symptomatic relief of cough.


See all Hycodan indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Hycodan (Hydrocodone / Homatropine)

Cold and Cough Medicine for Infants and Children: A Doctor's View
Source: MedicineNet Chronic Cough Specialty [2016.04.11]
Title: Cold and Cough Medicine for Infants and Children: A Doctor's View
Category: Doctor's & Expert's views on Symptoms
Created: 10/18/2007 12:00:00 AM
Last Editorial Review: 4/11/2016 12:00:00 AM

Children's Cough Causes and Treatments
Source: MedicineNet Allergy Treatment Begins At Home Specialty [2016.03.15]
Title: Children's Cough Causes and Treatments
Category: Diseases and Conditions
Created: 11/19/2012 12:00:00 AM
Last Editorial Review: 3/15/2016 12:00:00 AM

Waning Whooping Cough Immunity Blamed in Outbreaks
Source: MedicineNet Pertussis Specialty [2016.02.05]
Title: Waning Whooping Cough Immunity Blamed in Outbreaks
Category: Health News
Created: 2/5/2016 12:00:00 AM
Last Editorial Review: 2/5/2016 12:00:00 AM

Whooping cough booster vouchers don't boost immunization rates of caregivers
Source: Caregivers / Homecare News From Medical News Today [2016.02.04]
Cases of pertussis (whooping cough) have increased dramatically over the past five years, putting infants at risk of serious illness or death.

Microscopic view of coughed-up mucus may be new biomarker for cystic fibrosis progression
Source: Cystic Fibrosis News From Medical News Today [2015.10.14]
Cystic fibrosis is a disease that causes very thick mucus secretions to build up within the lungs, which in turn, leads to inflammation and chronic lung infections.

more news >>

Published Studies Related to Hycodan (Hydrocodone / Homatropine)

Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. [2014]
(DEA) Schedule III narcotics... CONCLUSIONS: Both medications decreased NRS pain scores by approximately 50%.

A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. [2010.02]
OBJECTIVES: To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy. METHODS: Children 6 to 15 years of age were randomized to receive acetaminophen and hydrocodone (167 mg/2.5 mg/5 mL) for 3 days after surgery: Group A (N=39)-every 4 hours PRN, with standard postoperative instructions; Group B (N=34)-every 4 hours ATC, with standard postoperative instructions, without nurse coaching; and Group C (N=40)-every 4 hours ATC, with standard postoperative instructions, with coaching...

A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. [2010]
OBJECTIVES: To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy. METHODS: Children 6 to 15 years of age were randomized to receive acetaminophen and hydrocodone (167 mg/2.5 mg/5 mL) for 3 days after surgery: Group A (N=39)-every 4 hours PRN, with standard postoperative instructions; Group B (N=34)-every 4 hours ATC, with standard postoperative instructions, without nurse coaching; and Group C (N=40)-every 4 hours ATC, with standard postoperative instructions, with coaching...

Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers. [2009.04.01]
BACKGROUND: Non-medical use and abuse of prescription opioids is a significant problem in the United States. Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids. The purpose of this study was to directly compare the psychopharmacological profile of two widely prescribed and abused oral opioid combination products within the same subject... CONCLUSIONS: Consistent with a recent study published in this journal using identical doses of HYD and OXY (without ACET) in prescription opioid abusers (Walsh, S.L., Nuzzo, P.A., Lofwall, M.R., Holtman Jr., J.R., 2008. The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription drug abusers. Drug Alcohol Depend. 198, 191-202), we found little difference in the pharmacodynamic effects of HYD/ACET and OXY/ACET in non-drug-abusing volunteers.

Determination and pharmacokinetic study of hydrocodone in human plasma by liquid chromatography coupled with tandem mass spectrometry. [2009]
A rapid, highly sensitive and specific high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS-MS) quantitation method was developed and validated for the determination of hydrocodone in human plasma. Sample was extracted from 0.5mL heparinized plasma by a simple liquid-liquid extraction method and analyzed on a C18 column with a mobile phase of acetonitrile-water (78:22,v/v,0.1% acetic acid)...

more studies >>

Clinical Trials Related to Hycodan (Hydrocodone / Homatropine)

Single Dose Pharmacokinetics of Egalet´┐Ż Hydrocodone [Completed]

Pharmacokinetic Study of Hydrocodone/APAP in Chronic Pain Patients [Completed]
Objective is to evaluate the pharmacokinetics profile of hydrocodone's metabolite hydromorphone in patients who are taking hydrocodone on a routine basis for more than 3 months for chronic pain and correlate hydromorphone levels to their hydrocodone usage.

Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction [Completed]
The purpose of this study was to evaluate analgesic efficacy and safety of hydrocodone/acetaminophen compared to placebo in moderate to severe pain following molar extraction.

Efficacy and Safety of Hydrocodone Bitartrate (HYD) in Subjects With Moderate to Severe Chronic Low Back Pain [Completed]
The primary objective of this study is to evaluate the analgesic efficacy and safety of HYD tablets 20 to 120 mg once-daily dose compared to placebo in subjects with moderate to severe chronic low back pain uncontrolled by their current stable analgesic regimen

Long-term Safety of Once-daily Hydrocodone Bitartrate (HYD) Tablets For Moderate to Severe Chronic Nonmalignant and Nonneuropathic Pain. Includes a 24-week Extension Period. [Completed]
The primary objective of this study is to characterize the long-term safety of Hydrocodone Bitartrate (HYD) tablets 20 to 120 mg once-daily in subjects with chronic nonmalignant and nonneuropathic pain.

more trials >>


Page last updated: 2016-04-11

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