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Hycodan (Hydrocodone Bitartrate / Homatropine Methylbromide) - Summary

 
 



HYCODAN SUMMARY

ANTITUSSIVE

HYCODAN®
(Hydrocodone Bitartrate and Homatropine Methylbromide)
TABLETS AND SYRUP

CIII

Rx only

HYCODAN contains hydrocodone (dihydrocodeinone) bitartrate, a semisynthetic centrally-acting opioid antitussive. Homatropine methylbromide is included in a subtherapeutic amount to discourage deliberate overdosage.

HYCODAN (hydrocodone bitartrate and homatropine methylbromide) is indicated for the symptomatic relief of cough.


See all Hycodan indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Hycodan (Hydrocodone / Homatropine)

California Infants Hit Hard by Whooping Cough Epidemic: Report
Source: MedicineNet Pertussis Specialty [2014.12.05]
Title: California Infants Hit Hard by Whooping Cough Epidemic: Report
Category: Health News
Created: 12/4/2014 12:00:00 AM
Last Editorial Review: 12/5/2014 12:00:00 AM

When to Call the Doctor: Fever, Nausea, Diarrhea, Colds, and Coughs
Source: MedicineNet Bruises Specialty [2014.12.01]
Title: When to Call the Doctor: Fever, Nausea, Diarrhea, Colds, and Coughs
Category: Doctor's Views
Created: 12/20/2010 12:00:00 AM
Last Editorial Review: 12/1/2014 12:00:00 AM

Whooping Cough Vaccine Seems Safe in Pregnancy, Study Finds
Source: MedicineNet Pertussis Specialty [2014.11.12]
Title: Whooping Cough Vaccine Seems Safe in Pregnancy, Study Finds
Category: Health News
Created: 11/11/2014 12:00:00 AM
Last Editorial Review: 11/12/2014 12:00:00 AM

Placebos are 'more effective than no treatment' for children's coughs
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2014.10.28]
Both agave nectar and a placebo were more effective at reducing cough symptoms among children under 2 years than watchful waiting, according to a new study.

Placebo Treatment May Quiet Kids' Cough
Source: MedicineNet Botulism Specialty [2014.10.28]
Title: Placebo Treatment May Quiet Kids' Cough
Category: Health News
Created: 10/27/2014 12:00:00 AM
Last Editorial Review: 10/28/2014 12:00:00 AM

more news >>

Published Studies Related to Hycodan (Hydrocodone / Homatropine)

Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. [2014]
(DEA) Schedule III narcotics... CONCLUSIONS: Both medications decreased NRS pain scores by approximately 50%.

A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. [2010.02]
OBJECTIVES: To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy. METHODS: Children 6 to 15 years of age were randomized to receive acetaminophen and hydrocodone (167 mg/2.5 mg/5 mL) for 3 days after surgery: Group A (N=39)-every 4 hours PRN, with standard postoperative instructions; Group B (N=34)-every 4 hours ATC, with standard postoperative instructions, without nurse coaching; and Group C (N=40)-every 4 hours ATC, with standard postoperative instructions, with coaching...

A randomized clinical trial of the efficacy of scheduled dosing of acetaminophen and hydrocodone for the management of postoperative pain in children after tonsillectomy. [2010]
OBJECTIVES: To determine the effectiveness of around-the-clock (ATC) analgesic administration, with or without nurse coaching, compared with standard care with as needed (PRN) dosing in children undergoing outpatient tonsillectomy. METHODS: Children 6 to 15 years of age were randomized to receive acetaminophen and hydrocodone (167 mg/2.5 mg/5 mL) for 3 days after surgery: Group A (N=39)-every 4 hours PRN, with standard postoperative instructions; Group B (N=34)-every 4 hours ATC, with standard postoperative instructions, without nurse coaching; and Group C (N=40)-every 4 hours ATC, with standard postoperative instructions, with coaching...

Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers. [2009.04.01]
BACKGROUND: Non-medical use and abuse of prescription opioids is a significant problem in the United States. Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids. The purpose of this study was to directly compare the psychopharmacological profile of two widely prescribed and abused oral opioid combination products within the same subject... CONCLUSIONS: Consistent with a recent study published in this journal using identical doses of HYD and OXY (without ACET) in prescription opioid abusers (Walsh, S.L., Nuzzo, P.A., Lofwall, M.R., Holtman Jr., J.R., 2008. The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription drug abusers. Drug Alcohol Depend. 198, 191-202), we found little difference in the pharmacodynamic effects of HYD/ACET and OXY/ACET in non-drug-abusing volunteers.

Determination and pharmacokinetic study of hydrocodone in human plasma by liquid chromatography coupled with tandem mass spectrometry. [2009]
A rapid, highly sensitive and specific high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS-MS) quantitation method was developed and validated for the determination of hydrocodone in human plasma. Sample was extracted from 0.5mL heparinized plasma by a simple liquid-liquid extraction method and analyzed on a C18 column with a mobile phase of acetonitrile-water (78:22,v/v,0.1% acetic acid)...

more studies >>

Clinical Trials Related to Hycodan (Hydrocodone / Homatropine)

Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco [Recruiting]
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.

A Study to Evaluate the Pharmacokinetics of the Hydrocodone Extended-Release Tablet (CEP-33237) in Subjects With Normal Hepatic Function and Subjects With Moderate Hepatic Impairment [Recruiting]
The purpose of this study is:

1. To assess the pharmacokinetics of the hydrocodone bitartrate extended-release tablet in subjects with moderate hepatic impairment and in subjects with normal hepatic function.

2. To assess the safety and tolerability of the hydrocodone bitartrate extended-release tablet in subjects with moderate hepatic impairment and in subjects with normal hepatic function.

A Crossover Study to Assess the Bioequivalence of Hydrocodone Bitartrate Extended-Release Tablet [Recruiting]
The primary objective of this study is to assess the bioequivalence of two 45-mg hydrocodone bitartrate extended-release tablets and one 90-mg hydrocodone bitartrate extended-release tablet.

Efficacy and Safety of Hydrocodone Bitartrate (HYD) in Subjects With Moderate to Severe Chronic Low Back Pain [Recruiting]
The primary objective of this study is to evaluate the analgesic efficacy and safety of HYD tablets 20 to 120 mg once-daily dose compared to placebo in subjects with moderate to severe chronic low back pain uncontrolled by their current stable analgesic regimen

Hydrocodone For Pain Control in First Trimester Surgical Abortion [Recruiting]
The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.

more trials >>


Page last updated: 2014-12-05

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