Hycamtin (Topotecan Hydrochloride) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

HYCAMTIN drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

There is no known antidote for overdosage with HYCAMTIN. The primary anticipated complication of overdosage would consist of bone marrow suppression.

One patient on a single-dose regimen of 17.5 mg/m² given on day 1 of a 21-day cycle had received a single dose of 35 mg/m². This patient experienced severe neutropenia (nadir of 320/mm³) 14 days later but recovered without incident.

The LD₁₀ in mice receiving single intravenous infusions of HYCAMTIN was 75 mg/m²(CI 95%: 47 to 97).

CONTRAINDICATIONS

HYCAMTIN is contraindicated in patients who have a history of hypersensitivity reactions to topotecan or to any of its ingredients. HYCAMTIN should not be used in patients who are pregnant or breast-feeding, or those with severe bone marrow depression.