DOSAGE AND ADMINISTRATION
Humulin R (U–500) should only be administered subcutaneously. It is inadvisable to inject Humulin R (U–500) intravenously because of possible inadvertent overdosage.
It is recommended that an insulin syringe or tuberculin–type syringe be used for the measurement of dosage. Variations in dosage are frequently possible in the insulin–resistant patient, since the individual is unresponsive to the pharmacologic effect of the insulin. Nevertheless, accuracy of measurement is to be encouraged because of the potential danger of the preparation.
Insulin should be kept in a cold place, preferably in a refrigerator, but must not be frozen.
Do not inject insulin that is not water–clear. Discoloration, turbidity, or unusual viscosity indicates deterioration or contamination.
Use of a package of insulin should not be started after the expiration date stamped on it.