Humira (Adalimumab) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

MTX reduced adalimumab apparent clearance after single and multiple dosing by 29% and 44% respectively.

OVERDOSAGE

The maximum tolerated dose of HUMIRA has not been established in humans. Multiple doses up to 10 mg/kg have been administered to patients in clinical trials without evidence of dose-limiting toxicities. In case of overdosage, it is recommended that the patient be monitored for any signs or symptoms of adverse reactions or effects and appropriate symptomatic treatment instituted immediately.

CONTRAINDICATIONS

HUMIRA should not be administered to patients with known hypersensitivity to HUMIRA or any of its components.