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Herceptin (Trastuzumab) - Drug Interactions, Contraindications, Overdosage, etc



In clinical studies, administration of paclitaxel in combination with Herceptin resulted in a 1.5‑fold increase in trastuzumab serum levels [ see Clinical Pharmacology (12) ].

In drug interaction studies, the pharmacokinetics of docetaxel and paclitaxel were not altered when each was administered in combination with Herceptin.


There is no experience with overdosage in human clinical trials. Single doses higher than 8 mg/kg have not been tested.



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