NEWS HIGHLIGHTS
Published Studies Related to Hepatamine (Amino Acid Injection)
The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone. [2009.08]
Paget's disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder..
Competitive displacement of serum protein binding of radiopharmaceuticals with amino acid infusion investigated with N-isopropyl-p-123I-iodoamphetamine. [2009.08]
When a therapeutic drug is competitively displaced at the binding sites of serum proteins, the free fraction of the drug will be increased, with an increase in the manifestation of pharmacologic properties. In the case of molecular imaging probes, total clearance and tissue distribution are increased in such circumstances. The aim of this study was to observe the increase in cerebral accumulation of N-isopropyl-p-(123)I-iodoamphetamine ((123)I-IMP) using the protein-binding displacement method with amino acid infusion... CONCLUSION: Amino acid infusion can improve brain accumulation by competitive displacement of serum protein binding in vivo. Further similar studies are needed with other radiopharmaceuticals.
Identification of new 2-amino-3-methylimidazo[4,5-f]quinoline urinary metabolites from beta-naphthoflavone-treated mice. [2009.08]
Metabolism of the heterocyclic amine carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated in mice with and without 40 mg/kg beta-naphthoflavone (BNF). Following an oral dose of 40 mg/kg (14)C-IQ, a 24-h urine sample was collected... Therefore, differences in metabolism between mice treated with and without BNF may affect IQ tumorigenicity.
Biological evaluation of boronated unnatural amino acids as new boron carriers. [2009.07]
There is a pressing need for new and more efficient boron delivery agents to tumor cells for use in boron neutron capture therapy (BNCT). A class of boronated unnatural cyclic amino acids has demonstrated a remarkable selectivity toward tumors in animal and cell culture models, far superior to currently used agents in clinical BNCT...
Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. [2009.07]
The effects of SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], an aminofurazan-based Rho kinase inhibitor, on the pulmonary vascular bed and on monocrotaline-induced pulmonary hypertension were investigated in the rat... The decreases in pulmonary arterial pressure in response to SB-772077-B in monocrotaline-treated rats were smaller than responses in U46619-infused animals, and the analysis of responses suggests that approximately 60% of the pulmonary hypertensive response is mediated by a Rho kinase-sensitive mechanism.
Clinical Trials Related to Hepatamine (Amino Acid Injection)
Effect of Branched Chain Amino Acids on Muscle [Recruiting]
With aging, there is a decrease in muscle mass and function especially in the energy
storehouses of cells called mitochondria. Amino acids, the building blocks of protein, and
insulin have been shown to increase muscle mitochondrial protein synthesis and thereby
function. Branched chain amino acids which can only be provided in the diet seem to be key
in this process. Therefore in our study, our aim is to study the effect of branched chain
amino acids on muscle mitochondrial protein synthesis in both the young and elderly. By
doing so, we can then elucidate if branched chain amino acid supplementation has future
potential in improving quality of life and performance in the elderly. The study will
involve blood sampling and needle muscle biopsy.
Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation [Recruiting]
The general hypothesis is that in older adults muscle regrowth after an acute
musculoskeletal stress will be positively influenced by traditional physical rehabilitation,
and further enhanced by nutritional supplementation. Using state-of-the-art stable isotope
methodologies for the study of muscle metabolism and methodologies for the measurement of
cell signaling, we will test the following specific hypotheses: 1) Total knee arthroplasty
(TKA) induces an acute net protein catabolism mainly by reducing muscle protein synthesis;
2) TKA induced catabolism is attenuated by the ingestion of essential amino acids (EAA); 3)
EAA supplementation in combination with physical therapy (PT) will stimulate muscle protein
synthesis and mTOR signaling to a greater extent than PT with Placebo; and 4) EAA
supplementation during TKA PT rehabilitation will improve muscle strength, muscle volume and
functional outcomes to a greater extent than PT with Placebo.
Public Benefit: This research will focus rehabilitation efforts on specific and currently
unresolved mechanisms responsible for muscle loss following total knee replacement in older
adults. While knee pain due to bone arthritis is often alleviated after knee replacement,
complete return of physical function and independence is difficult to achieve. This research
will help to restore physical function and independence in the rapidly growing population of
older adults with knee arthritis.
Dietary Strategies to Promote Muscle Protein Anabolism in the Elderly [Recruiting]
Aging is associated with the loss of lean muscle mass, termed sarcopenia. Food intake and in
particular the ingestion of protein or amino acids has been shown to be a powerful stimulus
to promote net muscle protein anabolism. However this anabolic response following a
meal-like protein bolus seems to be blunted in the elderly as compared to young adults.
The first aim of this proposal is to investigate the post-prandial muscle protein synthesis
rates in young and elderly men in response to a meal-like protein bolus after a period of
rest or physical activity (study A). The rest trial (REST) will act as a proof-of-principle
study to examine the blunted protein synthetic response in the elderly, and as a control
trial in comparison with the exercise trial (EXC) to establish the surplus value of physical
activity prior to protein intake on muscle protein synthesis.
The second aim of this proposal is to determine the surplus value of an increased quantity
of the ingested protein bolus (study B). Large amounts of protein (40 and 60 g) will be
compared to a meal-like amount of protein (20 g) as a means to maximize plasma amino acid
availability and/or to stimulate muscle protein anabolism.
The third aim of this proposal is to study the differences in quality of the ingested
protein bolus (study C). Instead of significantly increasing the quantity of the protein
bolus, we will also apply a more practical approach to augment skeletal muscle protein
synthesis rates; modifying the digestibility or amino acid composition of a meal-like
protein bolus.
D-amino Acid Oxidase Inhibition (DAAOI-1) add-on Treatment for Chronic Schizophrenia [Recruiting]
Adjuvant N-methyl-D-aspartic acid (NMDA)-enhancing agents, such as GlyT-1 inhibitors and
NMDA-glycine site agonists have been demonstrated to be beneficial for chronic schizophrenia
patients. The purpose of this study is to evaluate efficacy and safety of add-on treatment
of an inhibitor of D-amino acid oxidase (DAAOI), DAAOI-1, in chronically stable
schizophrenia patients who have been stabilized with antipsychotics.
Amino Acid and Acylcarnitine Profiles in Premature Neonates [Recruiting]
Primary Hypotheses of the study include:
- Metabolic profiles are influenced by gestational age, chronological age, type and
degree of nutritional support and illness
- Metabolic profiles differ between neonates who receive commercial formula and neonates
who receive primarily human breast milk
- Neonates who develop parenteral associated cholestasis have metabolic markers that
identify at risk patients (high serum urea nitrogen, citrulline, histidine, methionine,
and succinyl carnitine and low thyroxine, serine and glutamate)
- Neonates that have hypothyroidism have abnormal metabolic profiles (low tyrosine
levels)
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