DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Heparin (Heparin Sodium) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Hemorrhage: Hemorrhage is the chief complication that may result from heparin therapy (see WARNINGS). An overly prolonged clotting time or minor bleeding during therapy can usually be controlled by withdrawing the drug (see OVERDOSAGE). It should be appreciated that gastrointestinal or urinary tract bleeding during anticoagulant therapy may indicate the presence of an underlying occult lesion. Bleeding can occur at any site but certain specific hemorrhagic complications may be difficult to detect:

a. Adrenal hemorrhage, with resultant acute adrenal insufficiency, has occurred during anticoagulant therapy. Therefore, such treatment should be discontinued in patients who develop signs and symptoms of acute adrenal hemorrhage and insufficiency. Initiation of corrective therapy should not depend on laboratory confirmation of the diagnosis, since any delay in an acute situation may result in the patient’s death.

b. Ovarian (corpus luteum) hemorrhage developed in a number of women of reproductive age receiving short- or long-term anticoagulant therapy. This complication if unrecognized may be fatal.

c. Retroperitoneal hemorrhage.

Local Irritation: Local irritation, erythema, mild pain, hematoma or ulceration may follow deep subcutaneous (intrafat) injection of heparin sodium. These complications are much more common after intramuscular use, and such use is not recommended.

Hypersensitivity: Generalized hypersensitivity reactions have been reported, with chills, fever and urticaria as the most usual manifestations, and asthma, rhinitis, lacrimation, headache, nausea and vomiting and anaphylactoid reactions, including shock, occurring more rarely. Itching and burning, especially on the plantar site of the feet may occur.

Thrombocytopenia has been reported to occur in patients receiving heparin with a reported incidence of 0 to 30%. While often mild and of no obvious clinical significance, such thrombocytopenia can be accompanied by severe thromboembolic complications such as skin necrosis, gangrene of the extremities that may lead to amputation, myocardial infarction, pulmonary embolism, stroke, and possibly death. (See WARNINGS and PRECAUTIONS.)

Certain episodes of painful, ischemic and cyanosed limbs have in the past been attributed to allergic vasospastic reactions. Whether these are in fact identical to the thrombocytopenia associated complications remains to be determined.

Miscellaneous: Osteoporosis following long-term administration of high doses of heparin, cutaneous necrosis after systemic administration, suppression of aldosterone synthesis, delayed transient alopecia, priapism and rebound hyperlipemia on discontinuation of heparin sodium have also been reported.

Significant elevations of aminotransferase (SGOT [S-AST] and SGPT [S-ALT]) levels have occurred in a high percentage of patients (and healthy subjects) who have received heparin.

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.



REPORTS OF SUSPECTED HEPARIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Heparin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Heparin side effects / adverse reactions in 72 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-03

Patient: 72 year old male

Reactions: Confusional State, Dysarthria, Brain Stem Haemorrhage, Unresponsive TO Stimuli, Headache

Adverse event resulted in: death

Suspect drug(s):
Clopidogrel
    Dosage: 75 mg, unk
    Indication: Aneurysm

Aspirin
    Dosage: 75 mg, qd
    Indication: Aneurysm

Heparin
    Indication: Thrombosis Prophylaxis

Other drugs received by patient: Antihypertensive Drugs



Possible Heparin side effects / adverse reactions in 45 year old female

Reported by a pharmacist from Canada on 2011-10-04

Patient: 45 year old female

Reactions: Intra-Abdominal Haemorrhage, Prothrombin Level Abnormal, International Normalised Ratio Increased

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Propofol
    Dosage: 20ml
    Indication: Product Used FOR Unknown Indication

Lactated Ringers (Lactated Ringers)
    Indication: Product Used FOR Unknown Indication

Sodium Chloride 0.9%
    Indication: Product Used FOR Unknown Indication

Midazolam HCL
    Dosage: 1mg/ml
    Indication: Product Used FOR Unknown Indication

Heparin
    Dosage: 5000ml
    Indication: Product Used FOR Unknown Indication

Sufentanil Citrate
    Indication: Product Used FOR Unknown Indication

Zemuron
    Dosage: 50 mg
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: (Calcium Gluconate); (Flagyl /00012501/); (Ancef /00288502/); (All Other Therapeutic Products); Nexium; Voluven; (Dexamethasone); Diovan HCT; Phenylephrine HCL; Plasma



Possible Heparin side effects / adverse reactions in 89 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-05

Patient: 89 year old male

Reactions: Atelectasis, Dysphagia, Dyspnoea, Haemoptysis, Foreign Body Aspiration, Delirium, Cough

Suspect drug(s):
Heparin



See index of all Heparin side effect reports >>

Drug label data at the top of this Page last updated: 2007-03-07

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2014