Hectorol Injection (Doxercalciferol) - Summary

SUMMARY

Doxercalciferol, the active ingredient in Hectorol, is a synthetic vitamin D analog that undergoes metabolic activation in vivo to form 1(alpha),25-dihydroxyvitamin D₂(1(alpha),25-(OH) ₂ D₂), a naturally occurring, biologically active form of vitamin D₂.

Hectorol is indicated for the reduction of elevated iPTH levels in the management of secondary hyperparathyroidism in patients undergoing chronic renal dialysis.

NEWS HIGHLIGHTS RELATED TO HECTOROL INJECTION

Published Studies Related to Hectorol Injection (Doxercalciferol)

Randomized, double-blinded phase II evaluation of docetaxel with or without doxercalciferol in patients with metastatic, androgen-independent prostate cancer. [2008.04.15]

Doxercalciferol safely suppresses PTH levels in patients with secondary hyperparathyroidism associated with chronic kidney disease stages 3 and 4. [2004.05]

Intermittent doxercalciferol (1alpha-hydroxyvitamin D(2)) therapy for secondary hyperparathyroidism. [2000.09]

Phase II study of doxercalciferol for the treatment of myelodysplastic syndrome. [2008.01]

Doxercalciferol treatment of secondary hyperparathyroidism. [2006.11]

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Clinical Trials Related to Hectorol Injection (Doxercalciferol)

A Phase 4, Conversion Study of Hectorol® Injection to Hectorol® Capsules in Stage 5 CKD Patients on Dialysis [Completed]

A Phase 4 Study to Determine Dosing of Hectorol® Capsules When Converting From Zemplar® Injection [Completed]

A Phase 4 Pharmacokinetic Study of Hectorol Injection and Zemplar Injection in CKD Subjects on Hemodialysis [Completed]

A Study to Evaluate the Safety and Effectiveness of Doxercalciferol Capsules in Patients With Moderate to Severe Psoriasis [Recruiting]

Study of Safety and Efficacy of Doxercalciferol in Patients With Chronic Kidney Disease, Stage 3 or 4, and Secondary Hyperparathyroidism [Completed]

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