Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. HALDOL Decanoate is not approved for the treatment of patients with dementia-related psychosis (see WARNINGS).
Haloperidol decanoate is the decanoate ester of the butyrophenone, HALDOL (haloperidol). It has a markedly extended duration of effect.
HALDOL Decanoate 50 and HALDOL Decanoate 100 are indicated for the treatment of schizophrenic patients who require prolonged parenteral antipsychotic therapy.
Published Studies Related to Haldol (Haloperidol)
Quetiapine versus haloperidol in the treatment of delirium: a double-blind,
randomized, controlled trial. 
delirious behavior... CONCLUSION: Low-dose quetiapine and haloperidol may be equally effective and safe
Faster onset of antimanic action with haloperidol compared to second-generation
antipsychotics. A meta-analysis of randomized clinical trials in acute mania. 
CONCLUSIONS: haloperidol shows a faster onset of antimanic action than
Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide
in schizophrenia. 
Oxidative stress may be involved in the pathophysiology of schizophrenia...
Efficacy and safety of olanzapine in the treatment of Japanese patients with
bipolar I disorder in a current manic or mixed episode: a randomized,
double-blind, placebo- and haloperidol-controlled study. 
manic/mixed episode... CONCLUSIONS: This was the first study to evaluate an atypical antipsychotic in
Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: A randomized controlled trial. [2011.11.03]
OBJECTIVES:: To evaluate the efficacy and safety of short-term low-dose intravenous haloperidol for delirium prevention in critically ill elderly patients after noncardiac surgery... CONCLUSIONS:: For elderly patients admitted to intensive care unit after noncardiac surgery, short-term prophylactic administration of low-dose intravenous haloperidol significantly decreased the incidence of postoperative delirium. The therapy was well-tolerated.
Clinical Trials Related to Haldol (Haloperidol)
Haloperidol Prophylaxis in Cardiac Surgery for Patients at Risk for Delirium [Recruiting]
Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital [Not yet recruiting]
This research study is being done to find out if one of two drugs, ketamine or haloperidol,
is better for treating agitation. Agitation is a state of extreme emotional disturbance
where patients can become physically aggressive or violent, endangering themselves and those
who are caring for them. Often chemical substances or severe mental illness is involved in
this level of agitation. Specifically, the investigators are interested in studying
agitation that is treated in the prehospital setting by paramedics. This study's hypothesis
is that ketamine is superior to haloperidol for treatment of agitation in the prehospital
Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial [Completed]
Haloperidol is known to be a safe alternative medication to control difficult pain, and has
been shown effective when compared to placebo for controlling headaches. Investigators
hypothesized that the combination of haloperidol and diphenhydramine would be a useful
medication choice for migraine headache patients in the emergency department in comparison
to a common migraine treatment regimen of metoclopramide and diphenhydramine.
Lamictal TM, Haloperidol Decanoate in Schizophrenia [Terminated]
The purpose of this study is to determine the effect of lamotrigine augmentation of
Haloperidol decanoate in the treatment of Resistant Schizophrenia predominantly by verbal
resistant hallucinosis: A randomized, double-blind, placebo-controlled, study.
Nadir A. Aliyev & Zafar N. Aliyev
Central Mental Clinic for Outpatients of Baku city of Azerbaijan Republic
OBJECTIVE: The current paper reports on a double-blind, randomized study of the
role of lamotrigine as an augmentation agent to haloperidol decanoate in the treatment
of out patient's schizophrenia with verbal resistant hallucinosis.
Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia [Completed]
The aim of this study was to compare the efficacy and safety of intramuscular 10 mg
olanzapine versus intramuscular 5 mg haloperidol plus lorazepam 2 mg in the treatment of
acute agitated schizophrenic patients of Taiwanese populations.
Reports of Suspected Haldol (Haloperidol) Side Effects
Self Injurious Behaviour (38),
Multiple Drug Overdose Intentional (34),
Psychotic Disorder (27),
Suicide Attempt (27),
Electrocardiogram QT Prolonged (21),
Extrapyramidal Disorder (21),
Death (20), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Haldol has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
Haldol review by medical professional caring for 23 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || psychotic out nof control patient|
|Dosage & duration:|| || 5mg taken given on a prn basis for the period of given on a prn basis|
|Other conditions:|| || borderline personality disorder|
|Other drugs taken:|| || ativan,|
|Benefits:|| || Was able to gain control after receiving the injection form of the medication.Was helpful in decreasing aggitation,psychosis,delusions.At the end of the required time in seclusion and after giving medication time to take effect patient was able to return to facility population without any further problems.Was able to maintain in a calm manner,much less aggitated and was able to meet to staff to discuss delional ideas.|
|Side effects:|| || Drownsy but no untoward effects.Patient was able to be put on routine dose of this medication after effectivness of medication was evaluated to help prevent further problems.When routine dosage was begun patient was given routine medications for any side effects.|
|Comments:|| || Patient became aggiatated,delusional and psychotic and needed to be medicated for safty of patient and others.Required seclusion for decrease stimuli for mediation to take effect.Patient was medicated and given the quiet of seclusion and was monitored for saftey.At the end of seclusion time was released and placed back into the facility mileu.|
Page last updated: 2014-11-30