Guanidine (Guanidine Hydrochloride) - Summary

GUANIDINE SUMMARY

GUANIDINE
HYDROCHLORIDE
Tablets

Chemically, guanidine (amino-methanamidine) hydrochloride is a crystalline powder freely soluble in water and alcohol.

Guanidine is indicated for the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis. The Eaton-Lambert syndrome is ordinarily differentiated from myasthenia gravis by the usual association of the syndrome with small cell carcinoma of the lung, but myography may be necessary to make the diagnosis.

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NEWS HIGHLIGHTS

Media Articles Related to Guanidine

Myasthenia Gravis
Source: MedicineNet Hemapheresis Specialty [2007.12.19]
Title: Myasthenia Gravis
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 12/19/2007

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Published Studies Related to Guanidine

Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. [2009.02]
BACKGROUND: Nitric oxide (NO) is produced by resident and inflammatory cells in the respiratory tract by the enzyme NO synthase (NOS), which exists in three isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS. NO production is increased in patients with COPD, and the production of NO under oxidative stress conditions generates reactive nitrogen species that may amplify the inflammatory response in COPD... CONCLUSIONS: These results suggest that the constitutive NOS isoform as well as iNOS might be involved in NO release and contribute to the high Calv and ONOO(-) production in patients with COPD. Trial registration: Clinicaltrials.gov Identifier: NCT00180635.

Effects of erythropoietin and aminoguanidine on red blood cell deformability in diabetic azotemic and uremic patients. [2001.12]
Impaired red blood cell-deformability (RBC-df) is noted in patients with diabetes and may play a role in the pathogenesis of microvasculopathy and nephropathy. We report the effects of erythropoietin (EPO) alone and combined with aminoguanidine (AG) for 1 year on RBC-df in predialysis patients (P-DPs) with renal insufficiency and in end-stage renal disease (ESRD) patients on maintenance hemodialysis (DPs)...

Relationship between mechanical properties and pentosidine in tendon: effects of age, diet restriction, and aminoguanidine in broiler breeder hens. [2000.09]
Nonenzymatic glycosylation contributes to the formation of crosslinks, which leads to the structural and functional deterioration of tissue protein... The age-related increase in Pt and loss of elasticity in the tendon was retarded by diet restriction and AG.

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Clinical Trials Related to Guanidine

Phase 1-2 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paraganglioma [Recruiting]
The purpose of this study is to determine whether iobenguane I 131 is safe and effective in patients with malignant pheochromocytoma or paraganglioma.

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