GRIFULVIN V SUMMARY
Griseofulvin is an antibiotic derived from a species of
Major indications for GRIFULVIN V are:
Tinea capitis (ringworm of the scalp)
Tinea corporis (ringworm of the body)
Tinea pedis (athlete's foot)
Tinea unguium (onychomycosis; ringworm of the nails)
Tinea cruris (ringworm of the thigh)
Tinea barbae (barber's itch)
GRIFULVIN V inhibits the growth of those genera of fungi that commonly cause ringworm infections of the hair, skin, and nails, such as:
Prior to therapy, the type of fungi responsible for the infection should be identified. The use of the drug is not justified in minor or trivial infections which will respond to topical antifungal agents alone.
North American Blastomycosis
Published Studies Related to Grifulvin V (Griseofulvin)
Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: results of two randomized, investigator-blinded, multicenter, international, controlled trials. [2008.07]
CONCLUSIONS: Data from this largest pediatric trial of terbinafine to date indicate that terbinafine is efficacious and well tolerated in the treatment of tinea capitis. Terbinafine is an effective alternative to griseofulvin against T. tonsurans tinea capitis.
Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: Results of two randomized, investigator-blinded, multicenter, international, controlled trials. [2008.03.29]
CONCLUSIONS: Data from this largest pediatric trial of terbinafine to date indicate that terbinafine is efficacious and well tolerated in the treatment of tinea capitis. Terbinafine is an effective alternative to griseofulvin against T tonsurans tinea capitis.
Therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole. [2005.02]
BACKGROUND: Tinea capitis is a relatively common fungal infection of childhood. Griseofulvin has been the mainstay of treatment for many years. However, newer oral antifungal agents are being used more frequently. OBJECTIVE: Our purpose was to evaluate the therapeutic efficacy of fluconazole in comparison with griseofulvin in the treatment of tinea capitis... CONCLUSION: Fluconazole constitutes an alternative but, because of greater availability and lower cost, griseofulvin remains the treatment of choice for tinea capitis.
Treatment of tinea imbricata: a randomized clinical trial using griseofulvin, terbinafine, itraconazole and fluconazole. [2004.01]
BACKGROUND: Griseofulvin has been the mainstay of treatment for tinea imbricata (TI) for decades; however, there have been few reports of efficacy of newer antifungals in the treatment of this condition. Many patients with TI have several obstacles to treatment due to their remote geographical locations and the primitive nature of their societies. OBJECTIVES: The aim of this study was to compare the efficacy of itraconazole, terbinafine and fluconazole with that of griseofulvin after 4 weeks of therapy... CONCLUSIONS: Griseofulvin and terbinafine are effective in the treatment of TI. The decision of whether to treat at all and which medication to choose depends greatly on the extent of involvement, the social situation, and the availability of resources such as laboratory testing and follow-up.
A randomized, double-blind, parallel-group, duration-finding study of oral terbinafine and open-label, high-dose griseofulvin in children with tinea capitis due to Microsporum species. [2002.05]
BACKGROUND: Tinea capitis, a common clinical pattern of dermatophyte infection in children is becoming a public health hazard in some countries. Several studies have reported terbinafine to be a safe and well-tolerated fungicidal drug for the treatment of this infection. However, the optimal treatment duration for its use in the treatment of tinea capitis caused by Microsporum species has not yet been determined. OBJECTIVE: (i) To establish the optimal duration for terbinafine treatment to bring about complete cure of tinea capitis due to Microsporum infection in a large paediatric population, and (ii) to obtain information on the maximum therapeutic effect of the existing therapy... CONCLUSIONS: Although there was no statistical trend between the duration of terbinafine treatment within the groups for complete cure at the end of study, there was a positive correlation between the daily dose of terbinafine (mg x kg(-1)) and complete cure. Terbinafine therapy for 6 weeks could represent an alternative to griseofulvin for the treatment of Microsporum tinea capitis. However, further clinical trials are required in order to optimize the dose regimen to allow higher cure rates to be reached.
Clinical Trials Related to Grifulvin V (Griseofulvin)
A Relative Bioavailability Study of Griseofulvin 125 mg/5 mL Suspension Under Non-fasting Conditions [Completed]
A Relative Bioavailability Study of Griseofulvin 125 mg/5 mL Suspension Under Fasting Conditions [Completed]
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 2 ratings/reviews, Grifulvin V has an overall score of 7.50. The effectiveness score is 6 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
Grifulvin V review by 35 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Fungus|
|Dosage & duration:|| || 3 pills every night taken 1 for the period of 6 weeks|
|Other conditions:|| || N/A|
|Other drugs taken:|| || N/A|
|Benefits:|| || The benefits of the treatment were clearing a fungal infection that plaqued me for a few months. |
|Side effects:|| || I did not experince any treatment side effects. However, I did get pregnant while taking the medicine, but I did not have any complications.|
|Comments:|| || I had to take 3 pills everyday for six weeks to clear up the fungal infection. The treatment was not hard, but it was effective.|
Grifulvin V review by 23 year old male patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Tinea Barbae|
|Dosage & duration:|| || 500 mg taken 1 a day for the period of 2 weeks|
|Other conditions:|| || none|
|Other drugs taken:|| || Doryx|
|Benefits:|| || None YET|
|Side effects:|| || None |
|Comments:|| || I was diagnosed with a fungal infection of the beard (or Tinea Barbae). It is a form of follicular infection caused by a fungus of the hair follicle. My derm cultured some of the dead skin cells and in the mean time while the results are pending, put me on Griseofulvin because my symptomns were positive for fungal (a bacterial culture was also administered and was ruled negative). This is a similar treatment for cases of Ringworm of the skin or scalp. Griseofulvin has poor absorption unless taken with a fatty meal. I take (1) 500 mg tablet a day for 4 weeks until I have my next check up. I just completed week 2 and have seen NO signs of improvement.|
Page last updated: 2008-08-11