GOLYTELY SUMMARY
A white powder in a 4 liter jug for reconstitution, containing 236 g polyethylene glycol 3350, 22.74 g sodium sulfate (anhydrous), 6.74 g sodium bicarbonate, 5.86 g sodium chloride, 2.97 g potassium chloride. When dissolved in water to a volume of 4 liters, GoLYTELY (PEG-3350 and electrolytes for oral solution) is an isosmotic solution having a mildly salty taste. GoLYTELY is administered orally or via nasogastric tube as a gastrointestinal lavage.
GoLYTELY is indicated for bowel cleansing prior to colonoscopy and barium enema X-ray examination.
NuLYTELY is indicated for bowel cleansing prior to colonoscopy.
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NEWS HIGHLIGHTS
Published Studies Related to Golytely (Polyethylene Glycol 3350)
A Randomized, Double-Blind, Placebo-Controlled Trial of Polyethylene Glycol Effects on Fasting and Postprandial Rectal Sensitivity and Symptoms in Hypersensitive Constipation-Predominant Irritable Bowel Syndrome. [2009.07.03]
Objective: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension and symptoms in hypersensitive constipation-predominant irritable bowel syndrome (IBS-C)...
SodiumPhosphate (NaP) versus polyethylene glycol-electrolyte lavage solution (PEG-ELS) tolerability: a prospective randomized study in patients with gynecological malignancy. [2008]
PURPOSE: The aim of the study was to evaluate patient tolerability and compliance to two bowel cleansing agents (PEG-ELS and NaP) as well as to compare the cost effectiveness... CONCLUSION: NaP was rated superior to PEG-ELS in terms of patient tolerability, compliance, completion of the regimen and cost effectiveness and should be the first-choice treatment.
Differences in taste between two polyethylene glycol preparations. [2007.12]
BACKGROUND AND AIMS: Polyethylene glycol preparations (PEG) are increasingly used for chronic constipation in both adults and children. There are some suggestions that PEG 4000 with orange flavour (Forlax) tastes better than PEG 3350 which contains salt (Movicolon). Poor taste is an important factor for non-compliance and is one of the leading causes of therapy failure. The aim of the study was to compare the taste of two commonly used PEG preparations, PEG 4000 and PEG 3350... CONCLUSION: PEG 4000 tastes better than PEG 3350. This may have implications for patient compliance and effectiveness of treatment in patients with chronic constipation.
Polyethylene glycol 3350 plus electrolytes for chronic constipation in children: a double blind, placebo controlled, crossover study. [2007.11]
OBJECTIVES: To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children... CONCLUSIONS: PEG+E is significantly more effective than placebo, and appears to be safe and well tolerated in the treatment of chronic constipation in children.
A randomized, multicenter, placebo-controlled trial of polyethylene glycol laxative for chronic treatment of chronic constipation. [2007.07]
OBJECTIVES: Polyethylene glycol (PEG) 3350 (MiraLAX) is currently approved for the short-term treatment of occasional constipation. This study was designed to compare the safety and efficacy of PEG laxative versus placebo over a 6-month treatment period in patients with chronic constipation... CONCLUSIONS: PEG laxative is safe and effective for use in patients with chronic constipation for 6 months.
Clinical Trials Related to Golytely (Polyethylene Glycol 3350)
Amitiza® Plus GoLYTELY® Versus Placebo Plus GoLYTELY® for Outpatient Colonoscopy Preparation [Recruiting]
The primary objective is to compare the effectiveness and tolerance of Amitiza®
(lubiprostone) plus GoLYTELY® (polyethylene glycol-electrolyte solution) versus placebo and
GoLYTELY ® (polyethylene glycol-electrolyte solution) as a bowel cleansing preparation for
colonoscopy.
A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely [Not yet recruiting]
Prior to colonoscopies, the colon is cleansed using a laxative. Golytely is approved by the
FDA for this purpose. Another laxative, called MiraLax, is approved by the FDA to relieve
constipation, but it is not approved specifically for preparation for a colonoscopy.
Nonetheless, it is commonly used in clinical practice for this purpose, just as is Golytely.
The purpose of this study is to compare Golytely and MiraLax in two ways: to see whether one
is better tolerated by patients than the other and to see whether one more effectively
cleanses the bowel than the other. The investigators' hypothesis is that these 2 bowel
preparation methods are equally effective in bowel cleansing, but that patients prefer
Miralax to Golytely.
Split Dose Golytely With Amitiza Pretreatment Versus Split Dose Golytely Plus Placebo in Outpatient Colonoscopy [Completed]
The primary outcomes of this procedure will be: 1. The cleanliness of the prep as measured by
the Ottawa Scale (attachment a). Secondary outcomes will be: 1. Patient satisfaction with the
prep measured by 5 point Likert scale (attachment b); 2. Procedure time; 3. The number and
size of polyps detected on examination.
HalfLytely Bowel Prep System for Colonoscopy [Completed]
The purpose of the this study was to compare the safety and efficacy of HalfLytely (2L
NULYTELY + 20mg bisacodyl) to NULYTELY for preparation prior to colonoscopy.
Compare the Efficacy of 2 Bowel Preparation Regimens (Same-Day Morning Versus Prior-Day Evening) for Afternoon Colonoscopies [Recruiting]
The study aims to study the adequacy of bowel preparation (colon cleansing) for afternoon
colonoscopies. The convention regime of giving bowel prep on the evening prior to the day of
the colonoscopy will be compared with that given on the morning of the day of the
colonoscopy. However, both the regimes will be for afternoon colonoscopies only. As there is
a longer period between taking the evening prep (5-9PM) and the afternoon (next day 1-4PM)
procedure, the morning prep is hypothesized to have better colon cleansing effect than the
evening prep.
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