Glycopyrrolate (Glycopyrrolate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Anticholinergics, including Glycopyrrolate Injection, can produce certain effects, most of which are extensions of their pharmacologic actions. Adverse reactions may include xerostomia (dry mouth); urinary hesitancy and retention; blurred vision and photophobia due to mydriasis (dilation of the pupil); cycloplegia; increased ocular tension; tachycardia; palpitation; decreased sweating; loss of taste; headache; nervousness; drowsiness; weakness; dizziness; insomnia; nausea; vomiting; impotence; suppression of lactation; constipation; bloated feeling; severe allergic reactions including anaphylactic/anaphylactoid reactions; hypersensitivity; urticaria, pruritus, dry skin, and other dermal manifestations; some degree of mental confusion and/or excitement, especially in elderly persons.

In addition, the following adverse events have been reported from post-marketing experience with glycopyrrolate: malignant hyperthermia; cardiac arrhythmias (including bradycardia, ventricular tachycardia, ventricular fibrillation); cardiac arrest; hypertension; hypotension; seizures; and respiratory arrest. Post-marketing reports have included cases of heart block and QTc interval prolongation associated with the combined use of glycopyrrolate and an anticholinesterase. Injection site reactions including pruritus, edema, erythema, and pain have also been reported.

Glycopyrrolate is chemically a quaternary ammonium compound; hence, its passage across lipid membranes, such as the blood-brain barrier is limited in contrast to atropine sulfate and scopolamine hydrobromide. For this reason the occurrence of CNS-related side effects is lower, in comparison to their incidence following administration of anticholinergics which are chemically tertiary amines that can cross this barrier readily.

REPORTS OF SUSPECTED GLYCOPYRROLATE SIDE EFFECTS / ADVERSE REACTIONS

Possible Glycopyrrolate side effects / adverse reactions in 21 year old female

Reported by a physician from Austria on 2012-04-26

Patient: 21 year old female weighing 65.0 kg (143.0 pounds)

Reactions: Drug Interaction, Atrioventricular Dissociation

Suspect drug(s):
Rocuronium Bromide
    Indication: Anaesthesia

Nitrous Oxide (IN Oxygen)

Glycopyrrolate

Ranitidine
    Indication: Anaesthesia

Diclofenac Sodium
    Indication: Anaesthesia

Midazolam
    Administration route: Oral
    Indication: Anaesthesia

Fentanyl
    Indication: Anaesthesia

Propofol
    Indication: Anaesthesia

Neostigmine

Possible Glycopyrrolate side effects / adverse reactions in 21 year old female

Reported by a health professional (non-physician/pharmacist) from Austria on 2012-04-27

Patient: 21 year old female weighing 65.0 kg (143.0 pounds)

Reactions: Drug Interaction, Atrioventricular Dissociation

Suspect drug(s):
Midazolam
    Dosage: 7.5 mg
    Administration route: Oral
    Indication: Anaesthesia Procedure

Propofol
    Dosage: 200 mg bolus + 400 mg/h
    Indication: Anaesthesia Procedure

Fentanyl
    Dosage: 0.15 mg
    Indication: Anaesthesia Procedure

Neostigmine
    Dosage: 3.2 mg
    Indication: Anaesthesia Procedure

Nitrous Oxide
    Dosage: 66%
    Indication: Anaesthesia Procedure

Rocuronium Bromide
    Dosage: 25 mg
    Indication: Anaesthesia Procedure

Diclofenac
    Dosage: 75 mg
    Indication: Anaesthesia Procedure

Ranitidine
    Dosage: 50 mg
    Indication: Anaesthesia Procedure

Glycopyrrolate
    Dosage: 0.6 mg
    Indication: Anaesthesia Procedure

Possible Glycopyrrolate side effects / adverse reactions in 21 year old female

Reported by a health professional (non-physician/pharmacist) from Austria on 2012-05-10

Patient: 21 year old female

Reactions: Atrioventricular Dissociation

Suspect drug(s):
Rocuronium Bromide
    Indication: Anaesthesia Procedure

Propofol
    Indication: Anaesthesia Procedure

Nitrous Oxide (Nitrous Oxide)
    Indication: Anaesthesia Procedure

Glycopyrrolate
    Indication: Anaesthesia Procedure

Fentanyl
    Indication: Anaesthesia Procedure

Diclofenac Sodium
    Indication: Anaesthesia Procedure

Midazolam HCL
    Indication: Anaesthesia Procedure

Ranitidine Hydrochloride
    Indication: Anaesthesia Procedure

Neostigmine (Neostigmine)
    Indication: Anaesthesia Procedure