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Glyburide (Glyburide) - Side Effects and Adverse Reactions



See and Sections. Hypoglycemia: PRECAUTIONS OVERDOSAGE

Cholestatic jaundice and hepatitis may occur rarely which may progress to liver failure; glyburide tablets should be discontinued if this occurs. Liver function abnormalities, including isolated transaminase elevations, have been reported. Gastrointestinal Reactions:

Gastrointestinal disturbances,, nausea, epigastric fullness, and heartburn are the most common reactions, having occurred in 1.8% of treated patients during clinical trials. They tend to be dose related and may disappear when dosage is reduced. eg

Allergic skin reactions,, pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions occurred in 1.5% of treated patients. during clinical trials. These may be transient and may disappear despite continued use of glyburide tablets; if skin reactions persist, the drug should be discontinued. Dermatologic Reactions: eg

Porphyria cutanea tarda and photosensitivity reactions have been reported with sulfonylureas.

Leukopenia, agranulocytosis, thrombocytopenia, Hematologic Reactions:

hemolytic anemia (see), aplastic anemia, and pancytopenia have been reported with sulfonylureas. PRECAUTIONS

Hepatic porphyria reactions have been reported with sulfonylureas; however, hepatic porphyria has not been reported with glyburide tablets and disulfiram-like reactions have been reported very rarely. Metabolic Reactions:

Cases of hyponatremia have been reported with glyburide and all other sulfonylureas, most often in patients who are on other medications or have medical conditions known to cause hyponatremia or increase release of antidiuretic hormone. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported with certain other sulfonylureas, and it has been suggested that these sulfonylureas may augment the peripheral (antidiuretic) action of ADH and/or increase release of ADH.

Changes in accommodation and/or blurred vision have been reported with glyburide and other sulfonylureas. These are thought to be related to fluctuation in glucose levels. Other Reactions:

In addition to dermatologic reactions, allergic reactions such as angioedema, arthralgia, myalgia and vasculitis have been reported.


Below is a sample of reports where side effects / adverse reactions may be related to Glyburide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Glyburide side effects / adverse reactions in 42 year old female

Reported by a individual with unspecified qualification from United States on 2011-10-03

Patient: 42 year old female weighing 99.0 kg (217.8 pounds)

Reactions: Drug Ineffective, Blood Glucose Increased

Suspect drug(s):
Metformin HCL
    Dosage: (1000 mg)
    Indication: Diabetes Mellitus

Insulin Glargine
    Dosage: (70 iu)
    Indication: Diabetes Mellitus

    Dosage: (10 mg)
    Indication: Diabetes Mellitus

Insulin Lispro
    Indication: Diabetes Mellitus
    Start date: 2011-06-01

Possible Glyburide side effects / adverse reactions in 57 year old female

Reported by a consumer/non-health professional from United States on 2011-10-04

Patient: 57 year old female

Reactions: Hypoglycaemia

Suspect drug(s):
Blinded: Saxagliptin
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-10-02

    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-03-25

Metformin HCL
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-03-25

Blinded: Placebo
    Indication: Type 2 Diabetes Mellitus

Possible Glyburide side effects / adverse reactions in 76 year old male

Reported by a physician from Brazil on 2011-10-05

Patient: 76 year old male weighing 102.0 kg (224.4 pounds)

Reactions: Dilatation Ventricular, Wheezing, Drug Interaction, Pyrexia, High Density Lipoprotein Decreased, Dyspepsia, Chest Pain, Blood Cholesterol Increased, Electrocardiogram Repolarisation Abnormality, Blood Glucose Increased, Ventricular Extrasystoles, Dyspnoea, Vomiting, Nausea, Aortic Calcification, Left Ventricular Hypertrophy, Coronary Artery Disease, Diastolic Dysfunction, Gallop Rhythm Present, Eosinophil Count Increased, Convulsion, Heart Rate Increased, Ejection Fraction Decreased, Aortic Dilatation, LOW Density Lipoprotein Increased, Hypertension, Respiratory Tract Infection, Leukocytosis

Adverse event resulted in: hospitalization

Suspect drug(s):

Other drugs received by patient possibly interacting with the suspect drug:
Metformin HCL

    Dosage: unk ukn, unk
    Indication: Partial Seizures
    Start date: 2002-12-01

See index of all Glyburide side effect reports >>

Drug label data at the top of this Page last updated: 2013-11-18

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