Glyburide tablets contain micronized (smaller particle size) glyburide, which is an oral blood-glucose-lowering drug of the sulfonylurea class. Glyburide is a white, crystalline compound, formulated as glyburide tablets of 1.25, 2.5, and 5 mg strengths for oral administration.
Glyburide tablets is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Published Studies Related to Glyburide
Glyburide is associated with attenuated vasogenic edema in stroke patients. 
is not known... CONCLUSIONS: Several surrogate markers of vasogenic edema appear to be reduced in
Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects. [2011.07]
AIM: To evaluate the pharmacokinetic interactions of the potent, selective, dipeptidyl peptidase-4 inhibitor, saxagliptin, in combination with metformin, glyburide or pioglitazone... CONCLUSIONS: Saxagliptin can be co-administered with metformin, glyburide or pioglitazone without a need for dose adjustment of either saxagliptin or these OADs. (c) 2011 Blackwell Publishing Ltd.
Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapy. [2011.05]
BACKGROUND AND OBJECTIVES: In ADOPT (A Diabetes Outcomes Prevention Trial), initial monotherapy with rosiglitazone provided more durable glycemic control than metformin or glyburide in patients with recently diagnosed type 2 diabetes. Herein, we examine differences in albumin excretion, renal function (estimated GFR), and BP over 5 years between treatment groups... CONCLUSIONS: Over a 5-year period, initial monotherapy with rosiglitazone retards the rise of ACR compared with metformin, preserves eGFR compared with glyburide, and lowers BP relative to both comparators. Copyright (c) 2011 by the American Society of Nephrology
Effects of rosiglitazone, glyburide, and metformin on beta-cell function and insulin sensitivity in ADOPT. [2011.05]
CONCLUSIONS: The favorable combined changes in beta-cell function and insulin sensitivity over time with rosiglitazone appear to be responsible for its superior glycemic durability over metformin and glyburide as initial monotherapy in type 2 diabetes.
Nateglinide provides tighter glycaemic control than glyburide in patients with Type 2 diabetes with prevalent postprandial hyperglycaemia. [2011.05]
AIMS: Postprandial hyperglycaemia in patients with Type 2 diabetes mellitus has been linked to the development of cardiovascular disease. This study compared the effects of mealtime (thrice-daily) nateglinide with once-daily glyburide on postprandial glucose levels in patients with Type 2 diabetes and postprandial hyperglycaemia... CONCLUSIONS: Nateglinide leads to greater reductions in postprandial glucose excursions and is associated with a lower risk of hypoglycaemia than glyburide in this selected population of patients with Type 2 diabetes. (c) 2011 The Authors. Diabetic Medicine (c) 2011 Diabetes UK.
Clinical Trials Related to Glyburide
Efficacy and Safety of TAK-559 Combined With Glyburide in Treating Subjects With Type 2 Diabetes Mellitus. [Terminated]
The purpose of this study is to determine the safety and efficacy of TAK-559, once daily
(QD), combined with glyburide in treating Type 2 Diabetes.
A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Glyburide in Healthy Volunteers [Completed]
The purpose of this study is to determine how multiple doses of canagliflozin (JNJ-28431754)
affect the pharmacokinetics (ie, how the body affects the drug) and pharmacodynamics (ie,
how the drug affects the body) of a single dose of glyburide.
Glyburide (RP-1127) for Traumatic Brain Injury (TBI) [Active, not recruiting]
This is a randomized, double-blind, placebo-controlled, multi-institutional study of IV
RP-1127 (Glyburide for Injection) begun within 10 hours of complicated mild, moderate or
severe traumatic brain injury (TBI).
Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. Systematic Review [Completed]
Since the publication in the New England Journal of Medicine (NEJM) in 2000 of the Langer's
trial comparing glyburide vs insulin in the treatment of gestational diabetes mellitus
(GDM), additional studies of oral agents for the treatment of GDM have been published
(observational, randomized controlled trials (RCT), and trials using other drugs like
Some meta-analysis to summarize the evidence have been published: Nicholson 2009 (including
4 RCT addressing different drugs), Dhulkotia 2010 (including 6 RCT addressing different
drugs, the meta-analysis combining all drugs altogether), Gui 2013 (including 5 RCT
addressing metformin vs insulin).
Oral agents are increasingly used for the treatment of GDM. Investigators aim to update the
evidence on RCTs comparing glyburide and metformin vs insulin or between them and summarize
this evidence using meta-analysis tools. Specifically, investigators aim at producing
distinct meta-analyses for each one of the three drug comparisons. This information is not
available in the literature since the most recent systematic reviews specifically dealing on
oral agents for the treatment of GDM have addressed a single drug comparison (Gui 2013) or
have combined different drug comparisons into a single meta-analysis (Dhulkotia 2010)
Glyburide Healthy Volunteer Study [Completed]
Glyburide is a medication that has been safely used for several decades to treat non-insulin
dependent diabetes. This pilot study seeks to evaluate whether glyburide, administered at
the lowest dose (1. 5 mg/dL daily) to healthy (non-diabetic) subjects is safe both physically
and cognitively. The investigators are hopeful that the results of this study will provide
the necessary foundation to evaluate this medication's use on a larger scale to determine
the feasibility of using glyburide in soldiers either prophylactically or for the treatment
of brain injury.
Reports of Suspected Glyburide Side Effects
Blood Glucose Increased (28),
Renal Failure Acute (25),
Lactic Acidosis (24),
Drug Interaction (19),
Deafness Neurosensory (18),
Completed Suicide (16),
Diarrhoea (16), more >>
Page last updated: 2015-08-10